Respiratory Viruses

Question 1

what are the 3 types of influenza viruses?

Answer 1

A
B
C

Question 2

Which type of influenza virus is most common and associated with greatest concerns?

Answer 2

A

Question 3

only influenza virus type that has an animal reservoir

Answer 3

A

Question 4

virus family of influenza

Answer 4

orthomyxoviridae

Question 5

virus family of adenovirus

Answer 5

adenoviridae

Question 6

virus family of rhinovirus

Answer 6

picornavirus

Question 7

influenza virion type

Answer 7

enveloped

Question 8

adenovirus virion type

Answer 8

non-enveloped

Question 9

rhinovirus virion type

Answer 9

non-enveloped

Question 10

influenza genome classification

Answer 10

8 segmented (-)ssRNA

Question 11

influenza is identified by:

Answer 11

surface antigens HA and NA

Question 12

what influenza surface antigen is critical to budding?

Answer 12

NA

Question 13

influenza mode of transmission

Answer 13

aerosol, large and small droplets

Question 14

influenza vaccine type

Answer 14

live attenuated

Question 15

how are influenza pandemics thought to arise?

Answer 15

from avian strains

Question 16

how are adenoviruses characterized?

Answer 16

by their serotype

Question 17

adenovirus genome

Answer 17

dsDNA

Question 18

adenovirus entry

Answer 18

via coxsackie-adenovirus receptor (CAR)

Question 19

how does adenovirus leave its capsid?

Answer 19

pH triggered capsid disassembly

Question 20

what are the 3 phases of adenovirus gene expression

Answer 20

immediate-early
early
late

Question 21

influenza transcription and replication take place where?

Answer 21

nucleus

Question 22

influenza control/treatment

Answer 22

antiviral tx (amantidine)
zanamivir (tamiflu)
supportive care

Question 23

how does tamiflu work against influenza virus?

Answer 23

blocks release of budding virions

resistance uncommon

Question 24

how does antiviral treatment work against influenza virus? (amantidine)

Answer 24

blocks entry, inhibits M2 (influenza ion channel) activity

resistance common

Question 25

avian influenza

Answer 25

H5N1 H5 or H7 strains highly pathogenic

Question 26

why does avian influenza replicate so much in body?

Answer 26

HPAI strains leave residues at HA cleavage site which allows replication throughout body

Question 27

H5N1 is characterized by:

Answer 27

skin lesions, necrotic & swollen combs, systemic infection

Question 28

immediate-early phase of gene expression in adenovirus

Answer 28

E1A portion of genome

Question 29

early phase of gene expression in adenovirus

Answer 29

5 genome sections | DNA replication & post-transcriptional events

Question 30

late phase of gene expression in adenovirus

Answer 30

take over of cellular mRNA synthesis

Question 31

adenovirus genome replication

Answer 31

replicated 5' to 3' | one strand displaced

Question 32

adenovirus genome replication primed by

Answer 32

protein pTP

Question 33

adenovirus E3 gene produces proteins important to

Answer 33

host immune evasion

Question 34

adenovirus blocks

Answer 34

MHC-I expression to reduce CTL killing TNF induced apoptosis IFNa,b action keeping protein translation alive

Question 35

during what part of cell cycle does adenovirus DNA replication occur?

Answer 35

S phase

Question 36

T/F? majority of adenovirus respiratory disease occurs in people >14

Answer 36

false; under 14

Question 37

ARD is caused by adenovirus serotypes

Answer 37

4, 7

Question 38

adenovirus vaccine?

Answer 38

available to military personnel 17-50

Question 39

adenovirus respiratory disease symptoms

Answer 39

like common cold | inflammation, cough, nasal congestion

Question 40

rhinovirus is frequent cause of:

Answer 40

mild URT infections

Question 41

T/F? Rhinovirus has small antigenic diversity

Answer 41

false; over 100 serotypes making it difficul to develop vaccine

Question 42

rhinovirus vaccine?

Answer 42

no. too many serotypes | no antivirals either

Question 43

T/F? Rhinovirus has animal reservoir

Answer 43

false; human only

Question 44

rhinovirus symptoms

Answer 44

red nose, vessel dilation mucopurulent runny nose epithelial damage