Flashcards in Resting Potential Deck (12)
What is the membrane voltage equation?
How is depolarization achieved?
-Reduction in charge separation
-Less negative membrane potential
How is hyperpolarization achieved?
-Increase in charge separation
-More negative membrane potential
Which establishes ionic gradients - Ion pumps or ion channels?
Ion pumps ! active transporters which establish ionic gradients
Where are the following ions in higher concentration - outside or inside the cell?
1. K+ is higher inside
2. Na+ is higher outside
3. Ca2+ is MUCH higher outside
Is the direction of current flow defined as the direction of net movement of Positive or Negative charge?
What is the nernst equation?
E=RT/zF Log (X)2/(X)1
or just know:
E=61.5 Log (Koutside/Kinside)
What is the nernst equation used for ?
To calculate equilibrium potential (theoretical situation mostly)
What is the goldmans equation used for?
To calculate a steady state potential --> membrane potential (accounts for permeabilitites)
What is the Pna/Pk ratio or alpha of the goldman equation?
What is a result of interstitial hypokalemia (lower K+ concentration)
Cellular hyperpolarization (more negative)