Reticular Formation Flashcards

(46 cards)

1
Q

What is arousal?

A

The emotional state associated with some kind of goal or avoidance of something noxious

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2
Q

What is consciousness?

A

Difficult to determine, something to do with ‘awareness’ of both external world and internal states

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3
Q

What parts of the brain are required for consciousness?

A
  • Cerebral cortex
  • Reticular formation
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4
Q

What is the reticular formation?

A

A population of specialised interneurones in the brainstem

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5
Q

What inputs to the reticular system regulate the level of arousal?

A
  • Inputs from sensory system
  • Inputs from cortex
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6
Q

What are the widespread outputs from the reticular formation?

A
  • Thalamus
  • Hypothalamus
  • Basal forebrain
  • Spinal cord
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7
Q

What is the part of the reticular formation that is devoted to arousal?

A

The reticular activating system

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8
Q

Where is the reticular formation found?

A

In the brainstem

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9
Q

What does the reticular formation consist of?

A

Diffuse population of interneurones

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10
Q

What are the major inputs to the reticular system?

A
  • Sensory system
  • Cerebral cortex
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11
Q

Describe the relationship between the reticular activating system and the cerebral cortex?

A

The cerebral cortex sends excitatory projections to the reticular formation, and the reticular formation activates the cortex - mutual excitation produces a positive feedback loop

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12
Q

What is the importance of the positive feedback loop produced between the cerebral cortex and the reticular activating formation?

A

It produces an all or nothing phenomenon which is required to maintain the awake state

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13
Q

Give two methods of assessing consciousness

A
  • The glasgow coma scale
  • EEG
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14
Q

What does the EEG measure?

A

Combined activity of thousands of neurones in a given part of the cortex

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15
Q

Describe the resolution of the EEG

A
  • Very high temporal resolution
  • Very poor spatial resolution
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16
Q

What do neurones in the brain tend to do when deprived of sensory input?

A

Fire synchonously

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17
Q

What happens to the EEG during sleep?

A

You typically pass through 6 stages of sleep, progressing from an awake state through to stage 4, and then periodically going from stage 4 rapidly up into REM sleep

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18
Q

What does the EEG show going down to the first 4 stages of sleep?

A

Decreasing frequency and increasing amplitude, as neuronal populations in the cortex become synchronous

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19
Q

Describe the brainwaves in an awake person

A
  • ß-waves at about 50Hz
  • Irregular
20
Q

Why are the brainwaves in an awake person irregular?

A

Because you are processing sensory input

21
Q

Describe the brain waves of a person with their eyes closed

A
  • Alpha waves, at about 10Hz frequency
  • More regular
22
Q

What happens with increasing synchronicity amongst neurones?

A

Increased amplitude

23
Q

Describe the brainwaves in stage 1 sleep

A

Background of alpha waves with occasional low frequency θ waves at about 5Hz

24
Q

Describe the brainwaves in stage 2/3 sleep

A

Background of θ, but ocassional bursts of activity called sleep spindles. Occassionally get very big waves called K complexes

25
What are sleep spindles?
Attempt by the thalamus to wake the cortex - *K complex is the cortex trying to go back to the intrinsic rate*
26
Describe the brainwaves in stage 4 of sleep
Just see delta waves at a frequency of 1 per second, *as cortex is now acting independantly of reticular formation*
27
What is the neural mechanism of sleep?
Complex, but is basically about 'deactivating' the reticular activating system, and hence teh cortex, and inhibiting the thalamus
28
What happens to the positive feedback loop between the reticular activating system and the thalamus in sleep?
It is inhibited, *leading to decreased cortical activity*
29
What is inhibition of the positive feedback loop between the reticular activating system and the cortex assisted by?
Removal of sensory inputs
30
What is REM sleep initiated by?
Groups of neurones in the pons
31
Describe the EEG activity in REM sleep
SImilar to that seen during arousal, with beta waves
32
Why is the person difficult to rouse in REM sleep?
Due to strong inhibition of the thalamus
33
What happens to muscle tone in most of the body during REM sleep?
It is lost due to descending inhibition of LMNs by glycinergic fibres arising from the reticular formation, and running down the reticulospinal tracts
34
What functions are preserved during REM sleep?
Eye movements and some other cranial nerve functions
35
What autonomic effects are seen during REM sleep?
* Penile erection * Loss of thermoregulation
36
How is penile erection during REM sleep clinically useful?
Good for determining if physiological or psychological impotence
37
Give three examples of disorders of sleep
* Insomnia * Nacrolepsy * Sleep apnoea
38
What are the common causes of insomnia?
Anxiety and mental health ## Footnote *Rarely neurological*
39
Give four examples of disorders of consciousness
* Brain death * Coma * Persistent vegetative state * Locked in syndrome
40
What is brain death?
Widespread cortical and braimstem damage
41
What is shown on the EEG in brain death?
Flatline
42
What is a coma?
Widespread brainstem and cortical damage, with various (disordered) EEG patterns detectable. Unarousable and unresponsive to psychologically meaningful stimuli.
43
Is a sleep-wake cycle detectable in coma?
No
44
How does persistant vegetative state differ from a coma?
* Some spontaneous eye opening * Can localise stimuli via brainstem reflexes * Sleep-wake cycle detectable
45
What can locked in syndrome be caused by?
Basilar/pontine artery occlsuion
46
What happens to motor functions in locked in syndrome?
Eye movements can be preserved, but all other somatic motor functions are lost from the pons down