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Flashcards in Retroviridae Deck (73)
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1

Pro genes of retroviruses encode

Protease

2

Characteristics of Deltaretroviruses

Complex 

Type C Morphology

Gag, Pro, Pol, Env, rex and tex - Gag, Pro and Pol presented in 3 different reading frames

Exogenous

3

Feline Immunodeficiency Virus (FIV) belongs to what genus of retroviruses

Lentivirus

4

Type C Retrovirus

Assemble at plasma membrane and contain central symmetrically placed spherical inner core

5

Most common form of avian leukosis of chickens 4-30 weeks old

Lymphoid Leukosis

6

Retroviruses that cause chronic transformation do so by

Insertion/mutation through random integration into the genome of the host

7

Retroviruses that infect chickens belong to what retrovirus groups

Alpharetrovirus

Gammaretrovirus

8

Incubation period of FIV

Long incubation period - may last as long as 6 years

9

Characteristics of Betaretroviruses

Simple

Type B or Type D morphology

Assembled in cytoplasm via Type A intermediate

Gag, Pro, Pol, Env - Gag, Pro and Pol in different reading frames

Endogenous and Exogenous

10

Main determinant of FeLV pathogenicity

Surface Glycoprotein

11

Retrovirus virions are resistent to

Ultraviolet or X-rays

12

How do insects transmitt Equine Infectious Anemia Virus

When feeding fly is interrupted it will fly to another horse and transmit the virus

13

Gag gene of retroviruses encode

Virus core proteins: capsid, nucleocapsid, matrix

14

Secondary effects of thrombocytopenia seen with what retrovirus?

Equine Infectious Anemia Virus

15

Lymphoid Leukosis

Pale combs or cyanotic

Nodular lesions in teh bursa fabricuiuc containing B lymphocytes

16

Shape and position of the core was used to classify retroviruses into what categories

Type A - Type D

17

Equine infectious anemia virus - Swamp Fever - is transmitted through

Blood

Secretions 

Insects

18

Disease caused by what retrovirus?

Erythroblastosis

Avian Retrovirus

19

Viral oncogenes undergo transformation to remove

regulatory mechanisms

20

FIV replicates in what cells

Lymphocytes mostly CD4+ T cells, B cells and macrophages

21

Characteristics of Lentiviruses

Complex

Cylindrical or Conical Shaped Core

Gag, Pro, Pol, Env, Vif, Vpr, Vpo, Tat, Rev and Nef - Gag separate from Pol and Pro in same reading frame

Exogenous

22

Characteristics of Gammaretroviruses

Simple

Type C morphology

Gag, Pol, Pro, Env - Gag, Pro, Pol in same reading frame

Endogenous and Exogenous

23

Endogenous gammaretroviruses

Endogenous Feline Leukemia Virus (enFeLV)

RD114 Virus

24

FIV is transmitted by

Deep bite wounds and scratches

25

Characteristics of Retroviruses

Enveloped

Budd from cell membrane

Single Stranded

+ Sense RNA

26

Diagnose FeLV

p27 ELISA

Immunofluorescence Assay (IF)

Virus isolation in cell culture

27

FeLV subtype T

Tropism for T lymphocytes

28

FeLV is shed from an infected cat through

Saliva

Nasal Secretions

Feces

Milk

29

Oncogenic genes of avian retroviruses are transmitted

Horizontally or vertically through infectious virus or provirus integrated into host germ cell DNA

30

Diagnose FIV

ELISA