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Rhabdoviridae Flashcards

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1
Q

All Lyssaviruses cause what sort of disease?

A

Rabies or Rabies-like disease

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2
Q

Bovine Ephemeral Fever Virus belongs to what Rhabdovirus genus

A

Ephemorovirus

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3
Q

Clinical sign of what Rhabdovirus

A

Novirhabdovirus - Viral haemorrhagic Septicemia Virus

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4
Q

Exposure to Viral Hemorrhagic Septicemia virus is characterized by

A

Lethargy

Spiral Swimming Pattern

Darkened body color

Pale gills

Exophthalmia

Hemorrhage at base of fins

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5
Q

Clinical sign of what Rhabdovirus

A

Vesiculovirus

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6
Q

Rhabdovirus virions are released from the host cell by

A

budding

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7
Q

Vesicular Stomatitis Virus is transmitted by

A

Biting insects

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8
Q

Viral Hemorrhagic Septicemia Virus infection occurs at what water temperatures

A

4-14C, disappears at temperature >15C

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9
Q

What histiologic finding is diagnostic of Rabies Virus infection?

A

Negri bodies

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10
Q

Rhabdovirus protein that is an inner protein that facilitates virion budding - binds N and G proteins

A

M Protein

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11
Q

Clinical features of Vesicular Stomatitis Virus in cattle and horses

A

Excessive salivation and fever

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12
Q

Incubation period of Rabies Virus

A

14-90 days, even years

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13
Q

What type of sample should be collected for rabies virus detection

A

Tissue from at least two locations in the brain

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14
Q

Characteristics of excitative (fury) phase of rabies virus infection

A

Severe agitation and aggressiveness

Animal often bites any material

Rabid dogs develop typical high barking sound

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15
Q

Internal lesions associated with Viral Hemorrhagic Septicemia Virus infection

A

Hemorrhage in several organs

Liver is mottled and variably congested

Multifocal necrosis in several organs

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16
Q

Viral Hemorrhagic Septicemia Virus causes what type of disease in fish

A

Systemic infection

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17
Q

Gold standard laboratory diagnostic test for Rabies Virus

A

Fluorescent Antibody Test (FAT)

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18
Q

Four genera that make up Family Rhabdoviridae

A

Lyssavirus

Vesiculovirus

Ephemerovirus

Novirhabdovirus

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19
Q

Clinical Features of Bovine Ephemeral Fever Virus infection

A

Seasonal

Biphasic/Polyphasic Fever

Immediate drop in milk production

Cessation of rumination

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20
Q

Pathogenesis of Rabies Virus

A
  • Virus replicates in the muscle tissue
  • Accesses the peripheral nerves through sensory or motor nerves
  • Binds to receptor for Ach at neuromuscular junction
  • Infect the CNS
  • Replicates extensively in limbic system
  • Migrates to other organs - salivary glands
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21
Q

Protein that covers the surface of Rhabdoviruses

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A

G Protein (Glycoprotein)

22
Q

Rabies Virus is a member of what genus

23
Q

Bovine Ephemeral Fever Virus is transmitted by

24
Q

Infectious Hematopoietic Necrosis Virus belongs to what Rhabdovirus genus

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A

Novirhabdovirus

25
Most of rabies is caused by
Rabid dog bites
26
Clinical feature of Vesicular Stomatitis Virus in swine
Lameness
27
Rhabdovirus protein that makes up the major capsid compent, the viral nucleocapid
N Protein
28
Rhabdovirus virions are (stable/unstable) in the envriontment
Relatively stable
29
Clinical sign of what Rhabdovirus
Vesiculovirus
30
Viral Hemorrhagic Septicemia Virus belongs to what Rhabdovirus genus
Novirhabdovirus
31
Clinical Phases of Rabies Virus infection
Prodromal Phase Excitative (Fury) Phase Paralytic (Dumb) Phase
32
RNA Viruses Genome = Single Stranded, Linear, - Sense RNA Enveloped
Rhabdoviruses
33
Characteristic of paralytic (dumb) phase of rabies virus infection
Characterized by the inability to swallow - photophobia Leading to typical sign of foaming saliva around the mouth Some animals may develop paralysis beginning at the hind extremities Complete paralysis followed by death
34
Characteristics of the Prodromal Phase of Rabies Virus infection
Lasts 1-3 days with behavioral problems Aggressiveness in tame animals Daytime activities in nocturnal animals No fear in humans in wild animals Abnormalities in appetite
35
Rhabdovirus protein that is an RNA-dependent RNA polymerase - transcription and replication of viral RNA
L Protein
36
Characteristic microscopic lesions associated with what Rhabdovirus
Negri Bodies Rabies Virus
37
Rhabdovirus protein that is a co-factor of the viral polymerase
P Protein
38
Vesicular Stomatitis Virus belongs to what Rhabdovirus genus
Vesiculovirus
39
Vesicular Stomatitis Virus isolation method of choice
RT-PCR
40
Rabies virus is secreted in what during fury phase
Saliva
41
Rhabdovirus virion properties
RNA Virus Single Stranded Linear - sense RNA Enveloped Rod or Cone Shaped
42
Clinical features of Vesicular Stomatitis Virus in cattle and swine
Vesicls on tongue, oral mucosa, teats and coronary band
43
Clinical signs of infectious hematopoietic necrosis virus infection
Darkened body color Lethargy Pale gilles - anemia Bilateral exophthalmia Distention of abdomen - ascites Hemorrhage at base of fin
44
Rhabdovirus replication occurs in the
cytoplasm
45
Vesicular Stomatitis Virus is (stable/unstable) in the environment
Stable
46
Gold standard diagnostic test for Bovine Ephemeral Fever Virus
Virus isolation in mosquito cell culture or suckling mouse brain
47
Rabies virus reservoirs in North America
Skunks Raccoons Foxes Wolves
48
Clinical sign of what Rhabdovirus
Novirhabdovirus - Infectious Hematopietic Necrosis Virus
49
Bovine Ephemeral Fever Virus causes what disease
Three Day Stiff Sickness
50
Infectious Hematopoietic Necrosis virus infection occurs in what water temperature
Juvenile fish at water temperature 8-15C

RUSVM Virology (35 decks)

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