Circoviridae Flashcards Preview

RUSVM Virology > Circoviridae > Flashcards

Flashcards in Circoviridae Deck (30)
1

Clinical signs of Porcine Dermatitis and Nephropathy Syndrome (PDNS)

Necrotizing skin lesions

Necrotizing vasculitis

Necrotizing and fibrinous glomerulonephritis

2

Etiology of Chicken Infectious Anemia

Chicken Anemia VIrus (CAV)

3

Etiology of Post Weaning Multisystemic Wasting Syndrome (PMWS)

Porcine Circovirus 2

4

Circovirus viral DNA replication occurs in

the nucleus 

_____________________

Requires cellular proteins and other components produced during the S phase of the cell cycle

5

Common co infections associated with Post weaning multisystemic wasting syndrome

Porcine Parvovirus

Porcine Reproductive and Respiratory Virus

SIV

Mycoplasma hyopneumoniae

6

Diagnosis of Circovirus

Clinical Signs

Samples

Histopathology

Serological Assays

PCV2 nucleic acids by PCR

7

Diagnosis of Chicken Infectious Anemia

Clinical Signs

Examination of blood

Necropsy

Histopathology

Serology

Virus isolation

PCR

8

Vaccination for Post weaning multisystemic wasting syndrome

Chimeric Vaccine - utilize the non pathogenic porcine circovirus 1 as a genetic backbone for expression of immunogenic capsid protien of PCV2

9

Diseases associated with genus gyrovirus

Chicken Infectious Anemia

10

Transmisison of Post weaning multisystemic wasting syndrome

Fecal-Oral Transmission

Virus found in all secretions

Vertical Transmission - Transplacental transmission

Stable and survies on fomites

11

Host of Chicken Infectious Anemia

Highly contagious disease of young chickens 

________________

2-4 weeks of age

12

Distribution of post weaning multisystemic wasting syndrome (PMWS)

Worldwide

13

Clinical signs of post weaning multisystemic wasting syndrom 

Subclinical infection is most common

Lethargy, weight loss, cough, dyspnea, slow growth, lymphadenopathy, diarrhea, skin discoloration, congenital tremors, icterus

14

Describe the genome of Genus Gyrovirus

Circular, Single stranded negative sense DNA

15

Clinical signs of Chicken Infectious Anemia

Chicks are anorectic, lethargic, depressed, reduced body weight, and pale

Blood may be watery and clot slowly 

PCV low

Subcutaneous hemorrhages, skeletal hemorrhages and pale muscles

16

Characteristics of Porcine Dermatitis and Nephropathy Syndrome (PDNS)

Sporadic

Reported in older piglets

17

Transmission of Chicken Infectious Anemia

Virus shed in feces and feather dander

Horizontal transmission through inhalation or oral exposure

Vertical transmission through egg

Environmentally stable

18

Morphology of Chicken Infectious Anemia Virus

12 Trumpet like structures that are less obvious in other circoviruses

19

Porcine Circovirus 2 primarly targets

Cardiomyocytes

Hepatocytes

Macrophages - fetal life

Monocytes - post natal life

20

Apoptin Protein

Protein of Chicken Anemia Virus that induces apoptosis and cause destruction of infected lymphocytes

21

Etiology of Porcine Dermatitis and Nephropathy Syndrome (PDNS)

Porcine Circovirus 2

22

Circovirus replication occurs in 

Actively dividing cell

23

Characteristics of Family Circoviridae

Small viruses

Circular single stranded DNA genomes

Virions are small, nonenveloped, spherical

24

Effect of transplacental infection on the fetus

Infection during the first and second trimesters - fetal death and resorption or aborted fetuses with severe cardiace congestion

Infection during the last trimester has minimal effect on fetus

25

Principal sites of Chicken Infectious Anemia Virus replication are 

Hemocytoblasts in the bone marrow, precursor T cells in the cortex of the Thymus and dividing CD4 and CD8 cells in the spleen

26

Goal for vaccinating against chicken infectious anemia

Protect the progeny from vaccinated breeders from early infections by means of maternally derived antibodies

27

Post weaning multisystemic wasting syndrome is characterized by

Individual to coalescing foci of granulomatous inflammation in lymphoid tissues, lungs, liver, kidney, heart and intestines sometime with prominent botryoid intracytoplasmic inclusion bodies 

28

Host of Post Weaning Multisystemic Wasting Syndrome (PMWS)

Pigs

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Most common at 4-6 wees or age or 2-3 weeks post weaning

29

Describe the genome of Genus Circovirus

Circular, single-stranded ambisense DNA

30

Consistent feature in pigs that develop clinical post weaning multisystemic wasting syndrome

Lymphoid depletion and lymphopenia