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Flashcards in Retroviruses Deck (32)
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0

What are the characteristics of Retroviruses?

Enveloped, +ssRNA genome
Reverse transriptase to synthesize DNA from RNA
DNA integrates into host cell DNA

1

Retroviruses contains which two viruses?

Oncoviruses and Lentiviruses

2

What are the two forms of Oncoviruses?

HTLV-1 and HLTV-II

3

What does HTLV stand for?

Human T-Lymphotropic virus

4

How is HTLV-I transmitted?

By sexual contact, contaminated blood, mother to child

5

What happens to someone infected with HTLV-I?

About 1 in 25 infected persons develop cancer as a result of infection

6

What are the 2 Lentiviruses?

1- SIV(Simian Immunodeficiency Virus)
2- HIV (Human Immune Deficiency Virus)

7

How many forms of SIV are there?

18 SIVs causing infection in 20 species

8

What did SIV give rise to?

HIV-1 and HIV-2

9

What are the 2 forms of SIV we need to know?

SIV cpz and SIV sm

10

Who has SIV cpz and is most closely related to what?

Chimpanzee strain of SIV and most closely related to HIV-1

11

How did HIV-1 arise?

Arose are SIV cpz was transmitted from chimps to humans

12

What is SIV sm from and what is it related to?

SIV from Sooty Mangabey and most closely related to HIV-2

13

How many types of HIV are there?

2

14

What are the general ways that HIV-1 and HIV-2 are distinguished?

genetically and antigenically

15

Which form of HIV is the cause of the current pandemic and which one is found in west Africa but rarely elsewhere?

HIV-1 is the cause of the current pandemic and HIV-2 is in West Africa

16

What are the 3 groups of HIV-1?

M, N, and O

17

How many subgroups are there is HIV-1 M?

11 subgroups in M group - A to K

18

The Major subtype in North America, Latin America and the Caribbean, Europe, Japan and Australia is?

Type B

19

HIV-1 M subtype B is transmitted most effectively how?

By homosexual intercourse and via blood

20

How is HIV-1 types C and E transmitted?

found in Africa and transmitted via a heterosexual route

21

Where do HIV-1 types C and E replicate better?

Cervix, vagina and penis

22

Where does HIV-1 type B replicate better?

in the rectal mucosa

23

When was HIV-2 discovered?

1986

24

What are the similarities and differences between HIV-1 and HIV-2?

HIV-2 is transmitted in the same way as HIV-1, causes AIDS much more slowly than HIV-1 but otherwise clinically the diseases are very similar

25

What was the origin of HIV/AIDS?

Evidence suggests that HIV-1 originated in West Africa as SIV cpz was transmitted from chimps to humans in food preparation

26

What type of monkey is HIV-1 from?

Pan troglodytes troglodytes

27

When was the earliest documented case of HIV?

It was identified in the republic of Congo in a sample of serum that was stored in 1959

28

What are the 3 alternative ideas for the beginning of aids?

1-Drs Peter Dueserg and Kary Mullis
2-Koch's postulates
3-The River by Edward Hooper

29

What was the theory proposed by Drs Peter Duesberg and Kary Mullis?

That HIV is an unjustly maligned by-stander that is found in many immunocompromised states but is not the cause of disease