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Flashcards in Rhabdoviridae Deck (17)
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0

What are the characteristics of Rhabdoviridae viruses?

Bullet shaped enveloped virus
Single stranded negative RNA genome

1

Rhabdoviridae causes which disease?

Rabies

2

Where is rabies endemic?

Asia, Africa, and South America

3

How is rabies usually transmitted?

By an animal bite(infective saliva)

4

Rabies has been transmitted huma to human a few times. How did this happen?

with corneal transplants

5

The rabies virus binds to nerve or muscle cells at the site of inoculation via which receptors?

Nicotinic acetylocholine receptors

6

How long can the rabies virus remain at the site of inoculation before moving into other parts of the body?

weeks to years(average is 30 days)

7

What is the path of infection in the body from rabies?

Virus moves along the nerve axons tot he dorsal root ganglia and the spinal cord. From here, spreads to the brain occurs, infection of the brain leads to encephalitis

8

What happens in the prodrome phase of rabies?

pain of itching at the site of the wound, fever, headaches, GI

9

What are the neurologic effects of rabies that set in after the prodrome?

-CNS infection is apparent due to behavioral changes
-In up to half of patients, hydrophobia is seen
-Seizures and hallucinations

10

What happens after the neurologic phase with rabies?

The patient becomes comatose. Because of the neurological problems including respiratory paralysis, death ensues

11

What are the two forms of rabies in animals?

Furious form and Dumb form

12

Describe the furious form of Rabies

Animals can exhibit symptoms such as agitation and increased aggressiveness early on, followed by depression, paralysis, and eventual death

13

Can humans get the furious of dumb form of rabies?

no

14

Describe the dumb form of rabies

animals are lethargic, depressed, and eventually die

15

How is rabies diagnosed?

historically=negri bodies (inclusions in neurons in 50-80% of infected humans)

16

Rabies is controlled with vaccinations. Describe before and after options

-People at risk for rabies infection may be vaccinated as a preventative measure
-Post-exposure prophylaxis, inactivated vaccine and is strongly immunogenic, HGIG(human rabies immunoglobin) is also given in combination with the vaccine