Flashcards in Rhabdoviridae Deck (17)
What are the characteristics of Rhabdoviridae viruses?
Bullet shaped enveloped virus
Single stranded negative RNA genome
Rhabdoviridae causes which disease?
Where is rabies endemic?
Asia, Africa, and South America
How is rabies usually transmitted?
By an animal bite(infective saliva)
Rabies has been transmitted huma to human a few times. How did this happen?
with corneal transplants
The rabies virus binds to nerve or muscle cells at the site of inoculation via which receptors?
Nicotinic acetylocholine receptors
How long can the rabies virus remain at the site of inoculation before moving into other parts of the body?
weeks to years(average is 30 days)
What is the path of infection in the body from rabies?
Virus moves along the nerve axons tot he dorsal root ganglia and the spinal cord. From here, spreads to the brain occurs, infection of the brain leads to encephalitis
What happens in the prodrome phase of rabies?
pain of itching at the site of the wound, fever, headaches, GI
What are the neurologic effects of rabies that set in after the prodrome?
-CNS infection is apparent due to behavioral changes
-In up to half of patients, hydrophobia is seen
-Seizures and hallucinations
What happens after the neurologic phase with rabies?
The patient becomes comatose. Because of the neurological problems including respiratory paralysis, death ensues
What are the two forms of rabies in animals?
Furious form and Dumb form
Describe the furious form of Rabies
Animals can exhibit symptoms such as agitation and increased aggressiveness early on, followed by depression, paralysis, and eventual death
Can humans get the furious of dumb form of rabies?
Describe the dumb form of rabies
animals are lethargic, depressed, and eventually die
How is rabies diagnosed?
historically=negri bodies (inclusions in neurons in 50-80% of infected humans)