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BB Quiz1 Semi > Rh group (Molbio-Rh function) > Flashcards

Rh group (Molbio-Rh function) Flashcards

1
Q

Condition in which an antibody from the mother’s serum crosses the placental barrier and attacks the fetus’ cell;

A

HDN (Hemolytic disease of the Newborn)

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2
Q

What chromosome are RHD and RHCE
found?

A

Chromosome 1

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3
Q

present on most D-positive and all C- positive RBCs

A

Rh antigens – G antigen

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4
Q

variants or mutations of Rh antigen differs about how many amino acids

A

32-35 amino acids

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5
Q

RHD protein is flanked by

A

Rhesus boxes

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6
Q

at what residue does Serine was replaced by Asparagine

A

residue 68

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7
Q

Number of exons for RHD and RHCE

A

10

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8
Q

What is the most immunogenic antigen and the least immunogenic?

A

D > c > E > C > e
D: is the most immunogenic
e: is the least immunogenic

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9
Q

Isoleucine at residue 60 replaced

A

Leucine

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10
Q

Commericially produced and purified IgG class Anti-D w/ a latex molecule attached

A

Rh Immune Globulin (RhIG)

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11
Q

C and c differ by ____ amino acids

A

four

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12
Q

sources of Rh antigen-G antigen (3 pts)

A

RhD, RhCe, and RhCE protein

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13
Q

Where is RHAG located

A

Chromosome 6

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14
Q

links Rh complex to the membrane skeleton

A

Rh/RhAG-ankyrin interaction and CD47-protein 4.2 association

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15
Q

Serine at residue 68 replaced by

A

Asparagine

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16
Q

Rh Function

A

(1)Structural integrity of Red Cells
(2) Ammonia and CO2 transporters

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17
Q

She proposed that Rh was based on two Rh gene

A

Patricia Tippet

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18
Q

RHAG appears early in what progenitor

A

CD34+

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19
Q

E and e differ in what amino acid

A

Proline at residue 226 replaced by Alanine

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20
Q

replaced by tryptophan at residue 16

A

Cysteine

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21
Q

RHCE gene codes for

A

RhCe, RhcE, Rhce, RhCE

22
Q

True or False: RHAG cannot express Rh antigen alone

A

True

23
Q

RHD gene codes for

A

RHD protein

24
Q

Biochemically speaking, what type of molecules are Rh antigens?

A

Proteins

25
Q

Maintains structural integrity for the RBC

A

Rh antigens – “D”

26
Q

Located on chromosome 6, its product is similar in structure to the Rh proteins, with the difference being it is glycosylated.
- also called as COEXPRESSOR

A

Rh- associated glycoprotein (RhAG)

27
Q

Rh antigen “D” amino acid

A

416

28
Q

G-antigen is originally found on rr person who received:

A

D+C- E-c+e+

29
Q

RH and RHAG mRNAs are restricted to what cells

A

Erythroid lineages

30
Q

E and e differ by ____ amino acid

A

one

31
Q

four major allelic forms of RHCE:

A

ce, Ce, cE, and CE

32
Q

encodes E and e on the 4th extracellular loop

A

exon 5

33
Q

Anti-LW will not react with which of the following?

a. Rh-positive RBCs
b. Rh-negative RBCs
c. Rhnull RBCs
d. Rh:33 RBCs

A

Rhnull RBCs

34
Q

Rh Positive contains these gene

A

RHD AND RHCE

35
Q

number of times Rh antigen “D” traverses the cell membrane

A

12 times

36
Q

Rh antibodies are primarily of which immunoglobulin class?

A

IgG

37
Q

Single point mutation in Rhce resulted in

A

RHcE

38
Q

important in determining C or c

A

Position 103

39
Q

Single gene produces a single product that contains separately recognizable factors

A

Wiener

40
Q

differentiates E from e

A

Position 226 –

41
Q

A gene important for Rh antigen expression

A

RHAG

42
Q

ability of a particular substance(antigenorepitope) to provoke an immune responsetothebody of a human or animal

A

Immunogenecity

43
Q

Results from the amino acid serine at position 103 on the RhD, RhCe, and RhCE protein

A

Rh antigens – G antigen

44
Q

serine to proline happens in

A

residue 103

45
Q

Rh gene chromosome

A

Chromosome 1

46
Q

Percentage identity of RHAG gene to Rh indicidual

A

47%

47
Q

Rh locus contains 3 distinct genes that control production of their respective antigen

A

Fisher race

48
Q

Serine at residue 103 replaced by

A

Proline

49
Q

replaced by Proline at residue 103

A

Serine

50
Q

Where does Rh antigwn-“D” resides

A

Transmembranous proteins

BB Quiz1 Semi (5 decks)

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