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BB Quiz1 Semi > Weak D- Deficiency > Flashcards

Weak D- Deficiency Flashcards

1
Q

About 1% of D-positive individuals type as

A

Weak D

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2
Q

former name of weak D antigen

A

Du

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3
Q

Is weak D a new antigen? Yes or No

A

No, not a new antigen because people did not produce anti-Du but anti-D

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4
Q

Red Cells fails to react or reacts weakly to agglutination tests (but will react in IAT)

A

Weak D (Quantitative)

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5
Q

Cells carrying a weak D antigen require the use of what test to demonstrate its presence?

A

Indirect antiglobulin test

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6
Q
A
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7
Q

Rh antigen on RBC is normal, but the steric arrangement of the C antigen in relationship to the D antigen appears to interfere with the expression of D antigen

A

C-trans RHD

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8
Q

From the inheritance of RHD genes that code for weakened expression of the D antige

A

Weak D (Quantitative

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9
Q

The changes does not alter or remove any D epitopes therefore production of anti-Rh is not possible

A

Weak D (Quantitative)

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10
Q

Weak D expression that is common in black

A

Weak D (quanti)

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11
Q

antibody production in this type of expression is less likely

A

Weak D

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12
Q

People with this blood type can receive D positive RBCs

A

C trans in RHD

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13
Q

One or more D epitopes within the entire D protein is missing or altered

A

Partial D

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14
Q

individuals who were type D-positive express this antigen but produced an anti-D that reacted with all D-positive samples except their own

A

Partial D

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15
Q

In partial D, If an individual lacks one or more pieces(epitopes), of the total D antigen, what can be made to the missing epitopes if exposed to RBCs that possess the complete D antigen.

A

alloantibody

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16
Q

classified the antigens

A

Patricia Tippett and Ruth Sanger

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17
Q

Tested anti-D sera from D-positive people with RBCs from other D-positive people who also made anti-D

A

Patricia Tippett and Ruth Sanger

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18
Q

Number of categories Patricia Tippett and Ruth Sanger assigned for antigen

A

7

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19
Q

Antibody that Patricia Tippett and Ruth Sanger used to classify antigen

A

monoclonal(MAb-D)antibodies

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20
Q

Resulting protein contains a portion of RhD and RhCE in various combinations

A

Partial D

21
Q

Anti-D made by Partial D person can cause

A

HDN or HTR

22
Q

UseRh(-)blood for transfusion

A

Partial D

23
Q

Rh type used for partial D blood transfusion

A

Rh negative

24
Q

D epitopes is found on the surface of this protein

A

RhCE protein

25
Q

results from a hybrid gene“RHCE-RHD-RHCE”

A

R0Har – “DHAR”

26
Q

Only a small portion of RHD is inserted into the RHCE gene

A

RoHar

27
Q

If RoHar is paired with a normal RHD gene, the person will type

A

Rh positive

28
Q

found in individuals of African descent

A

Crawford antigen (ceCF)(Rh43)

29
Q

Due to a specific amino acid change in the Rhce gene

A

Crawford antigen

30
Q

Results for an RhD epitope on the Rhce protein

A

Crawford

31
Q

Phenotype in individuals whose RBCs possess an extremely low number of D antigen sites that most reagent anti-D are unable to detect

A

Del

32
Q

Mutant, RHD gene that alters expression of the RhD protein

A

Del

33
Q

In Del, splice site mutation happens in

A

exon 9 of RHD in Asians (or M295I mutation in whites)

34
Q

high incidence in Hong Kong Chinese and Japanese people

A

Del

35
Q

May be typed as D negative and can be found only when they stimulate production of anti-D in D negative individuals

A

Del

36
Q

May require adsorbing and elution techniques

A

Del

37
Q

process of gathering/pulling molecules onto the surface.

A

Adsorbing

38
Q

process of removing molecules from a source or cellular

A

Elution

39
Q

Have Rh negative with deletion of the RHD gene

A

European

40
Q

Genes that are only available in Rh negative European

A

2 RHCE genes

41
Q

Rh negative gene for Africans

A

RHD pseudogene (RHD ѱ)

42
Q

Rh negative allele in Africans have 37 base pair insertion at the

A

intron3/exon4

43
Q

Person with this gene does not produce RhD proteins

A

RHD pseudogene

44
Q

RHD pseudogene in Africans does not produce this protein

A

RHD

45
Q

Reagent use for indirect agglutination test

A

Coomb’s reagent

46
Q

Weak D positive reaction in indirect agglutination test

A

Agglutination

47
Q

fail to express any Rh antigens on the RBC surface

A

Rhnull

48
Q

Rhnull syndrome sign

A

–/–

BB Quiz1 Semi (5 decks)

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