Rheumatoid Arthritis Flashcards
1
Q
Methotrexate - csDMARD
A
Analog of folic acid
Increase adenosine levels
Anti-proliferative effects on T cells & inhibition of macrophage functions
Decrease in pro inflammatory cytokines
2
Q
Tofacitinib - tsDMARD
A
Janus Kinase (JAK) pathway inhibitor
Blocks cytokine production
(don’t combine w bDMARD
Side effect: immunosuppression
3
Q
Infliximab - bDMARD
A
TNF signalling blockers
4
Q
Anakinra - bDMARD
A
IL-1 signalling blocker protein
5
Q
Tocilizumab -bDMARD
A
Humanised IL-6 signalling blocker protein
6
Q
Hydroxychloroquine
A
Anti-malarial agents
Effective anti inflammatory agents in RA
Reduced MHC 2 expression & antigen presentation
7
Q
What are bDMARDs for?
A
For patients who do not respond well with sDMARD therapies (fake but imitated)
