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STEPH BPT 2021 > Rheumatology > Flashcards

Rheumatology Flashcards

(58 cards)

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1
Q

CPPD features

A

Calcification of wrist, MCP,

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2
Q

Genetics of RA

A

HLA DRB1*0404/01/05

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3
Q

Scoring for RA disease

A

Disease activity score 28
>5.1 is high
<2.6 is remission

Feet not included

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4
Q

Scleroderma renal crisis Ab

A

Anti-RNA polymerase III abs

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5
Q

Cardiac MRI finding SSC

A

Delayed contrast enhancement anteroseptal location

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6
Q

cANCA

A

Proteinase 3

Cytoplasmic staining

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7
Q

pANCA

A

Myeloperoxidase (MPO)

Perinuclear staining

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8
Q

PR3 associated vasculitis

A

GPA

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9
Q

MPO vasculitis

A

EGPA (only 40% positive for ANCA)
MPA
Necrotising crescenteric GN

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10
Q

GPA clinical manifestations

A

URT involvement
Nasal disease
Pulmonary manifestations
Renal

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11
Q

EGPA manifestations

A 
Asthma
Eosinophils 
Mononeuritis multiplex
Renal 
Skin
Pulmonary infiltration
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12
Q

ANCA Vasculitis Rx

A

Non organ threatening involvement

Pred
MTX

Organ threatening

Methyl pred
Cyclophosphamide or Rituximab

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13
Q

Antibody most specific for SLE

A

Anti ds-DNA

specific 87%

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14
Q

Anti RO

A

Sjogrens
SLE

Risk of cutaneous neonatal lupus and congenital heart block

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15
Q

Anti La

A

Sjögren’s syndrome

SLE

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16
Q

Anti SM (smith)

A

Cerebral and renal lupus

Most specific for lupus

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17
Q

Anti U1 RNP

A

MCTD

SLE

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18
Q

Antibody with negative association with lupus/autoimmune disease

A

Anti dense fine speckled 70

Anti DFS70

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19
Q

Mild lupus Rx

A

Hydroxychloroquine
Pred
AZA
MTX

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20
Q

Rx for SLE major organ involvement

A

Cyclophosphamide

Mycophenalate

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21
Q

Genetics with Spondyloarthritis

A

HLA B27
ERAP 1
IL -23R

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22
Q

TNF inhibitors

A

Etanercept
Infliximab
Adalimumab

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23
Q

Best AHTN for urate lowering property

A

Losartan

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24
Q

Risk in pregnancy with Anti Ro

Study These Flashcards
A

Congenital heart block

25
Drug induced lupus
Positive ANA ``` Hydrochlorothiazide Terbinafine Anti TNF drugs PPI NSAIDS ```
26
Antibody associated with immune mediated necrotising myopathies
HMG-CoA reductase antibodies Often triggered by statin use
27
Antibody associated with Polymyositis
Anti-Jo1
28
Antibody associated with associated with diffuse cutaneous systemic sclerosis
Anti-Scl-70 = anti-topoisomerase I
29
Ab associated with renal and neuropsychiatric Lupus
Anti-Sm (smith)
30
Ab associated with Goodpastures Disease
Anti-GBM
31
Ab most associated with dermatomyositis
Anti-Mi-2 antibody
32
Most specific Ab for RA
Anti-CCP
33
Cancer associated with Sjogren's syndrome
Lymphoma | Associated with Persistently high RF
34
CREST
``` Calcinosis Raynauds Eosophageal dysmotility Sclerodactyly Telengiectasia ```
35
Systemic sclerosis vs raynauds clinical finding
Nailfold capillary changes with SS
36
Anti-Jo association
Antisynthetase syndrome
37
Polymyositis Complications
Pulmonary Eosophageal/dysphagia Cancer
38
Neurostimulation site for PD
Subthalamic nucleus
39
Anti-centromere Ab
Limited Cutaneous Systemic Sclerosis
40
Complications of Sjogrens
``` Lymphoma Tubulointerstitial nephritis RTA type 1 IPF Dental Ophthalmic ```
41
Triad of sjogrens
Dry eyes Dry mouth Inflammatory arthritis
42
Diagnosis of Sjogrens
Opthalmic staining score Lip/labial biopsy (minor glands) Anti ro/la
43
Triggers of scleroderma renal crisis
Prednisolone | ACE not protective
44
Features suggestive of septic arthritis
WCC >50,000 >75% polys Cultures positive
45
``` Oral ulcers Genital ulcers Ovular disease Skin lesions GI manifestations Vasculitis ``` Positive pathergy test
Behcets disease
46
Skin manifestations sarcoid
Lupus pernio (involves nose/central face, increased risk for pulmonary sarcoid) Erythema nodosum
47
Most specific finding for PsA
Dactylitis
48
Treatment of RA
MTX sulphasalazine Hydroxychloroquine Leflonamide TNF inhibitor IL-6 inhibitor JAK inhibitors Start on NSAID and oral steroids
49
Treatment of dermatomyositis
Pred MTX/AZA for sparing
50
New murmur an APLS/SLE
Liberman-sach's endocarditis
51
Erosive arthritis of 2nd and 3rd MCP joints
Haemachromatosis
52
SScl with ILD Rx
Mycophenalate
53
Treatment of sarcoid
glucocortocoids
54
purpura, abdominal pain, and arthralgia
IgA vasculitis (Henoch-Schönlein purpura)
55
High dose steroids and unexplained groin pain
Avascular necrosis
56
RA splenomegaly cytopaenia
Felty Syndrome Rx: Steroids
57
aminoacyl-tRNA synthetase antibody
Antisynthetase
58
Rash findings dermatomyositis
Gottron's papules | Heliotrope rash

STEPH BPT 2021 (17 decks)

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