Routes of Administration Flashcards

1
Q

Advantages of Oral Administration

A
  1. Convenient for patient

2. Large surface area for absorption

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2
Q

Advantages of Topical Administration

A
  1. Convenient for patient

2. Low risk of overdosing

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3
Q

Advantages of Transdermal Administration

A

Long Acting

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4
Q

Advantages of Rectal Administration

A
  1. Local effect

2. Beneficial for patients who are vomiting or cannot swallow

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5
Q

Advantages of Inhalation Administration

A
  1. Rapid Response due to large absorption surface area

2. Local/ Systemic effect

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6
Q

Advantages of Parenteral Routes

A
  1. Rapid Action
  2. Bypass Stomach and Liver
  3. Lower Dose Required
  4. Can be controlled by patients
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7
Q

Disadvantages of Oral Administration

A
  1. Not suitable for all patients
  2. Absorption of drug can vary
  3. Absorption of drug can be interrupted by stomach contents
  4. Degrades in stomach
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8
Q

Disadvantages of Topical Administration

A
  1. Adverse skin effects

e. g skin thinning by hydrocortisone

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9
Q

Disadvantages of Transdermal Administration

A
  1. Adverse skin effects

2. Drug needs to be really potent an lipid soluble

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10
Q

Disadvantages of Rectal Administration

A
  1. Need to be trained to administer
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11
Q

Disadvantages of Inhalation Administration

A
  1. Difficult to ensure drugs reaches target cells

2. Patient need to be trained to use it

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12
Q

Disadvantages of Parenteral Routes

A
  1. High risk of overdosing
  2. Requires training for administration
  3. Painful
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13
Q

What is intravenous injection?

A

Injection to veins

e.g heparin, thiopental

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14
Q

What is intramuscular injection?

A

Injection to muscle

e.g pre-meds

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15
Q

What is intradermal administration?

A

Injection to skin

e.g Local Aesthetic

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16
Q

What is subcutaneous administration?

A

Injection into subcutis layer, below the dermis and epidermis
e.g Insulin

17
Q

What is Intrathecal administration?

A

Injection into the subarachnoid space

e.g Chemo Drugs

18
Q

What is Epidural administration?

A

Injection in epidural space

e.g Nerve blockers

19
Q

What is Transdermal administration?

A

Administration of drugs across the skin

20
Q

Examples of Rectal Drugs

A

Antifunagals
Anaglesics
Presdnisolone (reduces inflammation)
Diazepam (muscle relaxant)

21
Q

Examples of Inhalation Drugs

A

Halothane (anaesthetic)
Nitrous Oxide (anaesthetic)
GTN
Salbutamol (bronchodilator)

22
Q

What is Bioavailability?

A

Amount of drug that reaches the circulation as intact drug

23
Q

Sustained Release

A

Increase duration of drug
Decreased freq of dosing
Decrease of dose required