S3E1: Neurodegenerative dz Flashcards Preview

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Flashcards in S3E1: Neurodegenerative dz Deck (28):
1

levodopa

-increases DA levels
-DA precursor

2

carbidopa

peripheral dopa decarboxylase inhibitor

3

Carbidopa + levodopa (Sinemet): pros

-lower dose of levodopa
-fewer peripheral effects (N/V)
-more DA effect in CNS

4

Clozaril

Antipsychotic. Use if psychotic pt needs levodopa

5

Amantadine use

Antiviral and anti-parkinsons rx.
-increases release of DA (improves tremor, bradykinesia, rigidity)
-use to tx dyskinesia SE of levodopa

6

Wearing-off (of levodopa) tx

-increase dose/frequency of levodopa
-add DA agonist
-add catechol-O-methyl-transferase (COMT) inhibitor

7

Rasagiline (azilect)

MAO B inhibitor

8

Selegiline (eldepryl)

MAO B inhibitor. Increases DA levels

9

tolcapone (Tasmar)

COMT inhibitor

10

entacapone (Comtan)

COMT inhibitor

11

bromocriptine (parlodex)

DA receptor agonist

12

ropinirole (requip)

DA receptor agonist

13

apomorphine

DA receptor agonist

14

benztropine (Cogentin)

ACh receptor antagonist

15

trihexyphenidyl (artane)

ACh receptor antagonist

16

drugs that can cause parkinsonian syndrome

-haloperidol
-metoclopramide (reglan)
-phenothiazines (like compazine)

17

postural tremor tx

-propranolol
-primidone (barbiturate)
-topiramate (anticonvulsant)

18

tx of tics

haloperidol (if severe)

19

RLS tx

1. DA receptor agonists (ropinirole)
2. levodopa or benzos or opiates

20

donepezil (aricept)

-centrally acting cholinesterase inhibitor
-alzheimers tx

21

tacrine (cognex)

-centrally acting cholinesterase inhibitor
-alzheimers tx

22

rivastigmine (exelon)

-reversible cholinesterase inhibitor
-alzheimers tx

23

galantamine (razadyne)

-reversible cholinesterase inhibitor
-alzheimers tx

24

memantine (namenda)

-alzheimers tx

25

MS tx (dz modifying)

-beta interferons
-glatiramer acetate (copaxone)
-mitoxantrone (novantrone)
-natalizumab (tysabri)

26

Huntington tx

-haloperidol (antipsychotic)
-diazepam

27

ALS tx

riluzole (rilutek)

28

Parkinsons tx course

-start with amantadine +/- ACh antagonist
-then DA agonist +/- levodopa
-then add MAO B or COMTI