S3E3: Rheum Flashcards Preview

Pharm > S3E3: Rheum > Flashcards

Flashcards in S3E3: Rheum Deck (29):
1

Hydroxychlorquine

Immunomodulator

2

Sulfasalasine

Immunomodulator

3

Methotrexate

Immunosuppressant

4

leflunomide

Immunosuppressant

5

cyclophosphamide

Immunosuppressant

6

cyclosporine

Immunosuppressant

7

azathioprine

Immunosuppressant

8

mycophenlate

Immunosuppressant

9

Infliximab (remicade)

TNF-alpha inhibitor

10

Entanercept

TNF-alpha inhibitor

11

Adalimumab (humira)

TNF-alpha inhibitor

12

Golimumab

TNF-alpha inhibitor

13

Certolizumab

TNF-alpha inhibitor

14

Abatacept

Inhibit T cell activation

15

Rituximab

Inhibit cell cycle initiation

16

Anakinra

IL-1 inhibitor

17

Tocilizumab

IL-6 inhibitor

18

Tofacitinib (Xelganz)

JAK inhibitor

19

colchicine

Interrupts MSU deposition

20

probenecid

uricosuric agent

21

isosartan

uricosuric agent

22

fenobrate

uricosuric agent

23

allopurinol

xanthine oxidase inhibitor (lowers uric acid)

24

febuxistat

xanthine oxidase inhibitor (lowers uric acid)

25

Gout tx: Prevention

low dose colchicine + low dose NSAID

26

Gout tx: Acute (for mild and mod)

Mild attack: monotherapy (NSAID or colchicine or steroid)
Mod attack: colchicine + either NSAID or steroid

27

Gout tx: drugs to lower uric acid

Allopurinol or fubuxistat

28

RA tx (for mild, mod, and systemic sx)

Mild: NSAIDs
Mod: MTX 1st. Then add TNF-alpha inhibitor.
Systemic sx: hydroxychloroquine.

29

DMARDs

Immunomodulators
Immunosuppressants
Biologics (TNF-i, -mabs, -JAK, IVIG)