Samplex 2014 Set A Flashcards Preview

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Flashcards in Samplex 2014 Set A Deck (51)
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1

Which does not describe a drug?

A. It is a chemical with known structure.
B. It usually binds to regulatory molecules.
C. It is specific with its actions.
D. It activates or inhibits normal body processes

C

2

Which is true of the history of pharmacology?

A. In the 7th century, herbal medicine emerged.
B. Advancements in the knowledge of physiology and chemistry led to better evidence for therapeutic claims.
C. In recent years, biotechnology has emerged as a major basis of pharmacology.
D. Biopharmaceutics is the use of genetic information in the manufacture of drugs.

C

3

Which of the following is correct?

A. Pharmacokinetics is what the drug does to the body.
B. Pharmacodynamics is what the body does to the drug.
C. Selectivity is reciprocal.
D. There are drugs that are completely specific to a particular receptor.

C

4

The WHO defines essential medicines as:

A. All drugs produced by local manufacturers.
B. Drugs that answer the priority health care needs of the community.
C. Drugs intended to be used to modify or to explore physiological system or pathological states fo the benefit of the recipient.
D. All the expensive drugs.

B

5

Which is TRUE of Drug Action?

A. All drug molecules exert a chemical influence on cells initially through receptors.
B. Specificity of drug receptor interaction is reciprocal.
C. Occupation of receptor always transforms the receptor t to an active conformational state.
D. Drug is effective if it affects the most number of tissues and cells as possible.

B

6

Which receptor has the fastest response time?

A. Ion channel
B. G-protein coupled receptors
C. Tyrosine kinase linked receptors
D. Intracellular receptors

A

7

Which one of the following receptors takes hours to days to effect a cellular response?

A. Ion channel
B. G-protein coupled receptors
C. Tyrosine kinase linked receptors
D. Intracellular receptors

D

8

Compared to the sigmoid curve of a full agonist in the log dose vs. effect curve, the partial agonist:

A. will shift parallel to the right
B. will shift parallel to the left
C. Emax will be higher
D. Emax will be lower

D

9

Compared to the sigmoid curve of a full agonist in the log dose vs. effect curve, the presence of a competitive antagonist will:

A. shift to the right
B. shift to the left
C. Emax will be higher
D. Emax will be lower

A

10

Compared to the sigmoid curve of a full agonist in the log dose vs. response curve, the curve in the presence of a noncompetitive antagonist:

A. shift to the right
B. shift to the left
C. higher Emax
D. lower Emax

D

11

Which receptor modulates the allergic receptor

A. Beta adrenergic receptor
B. Histamine-1 receptor
C. Opiate receptor
D. Angiotensin converting enzyme converting receptor

B

12

G-protein coupled receptors are the most common receptor acted on by drugs?

A. True
B. False

A

13

Covalent bonds are usually irreversible.

A. True
B. False

A

14

Agonist binding has both affinity and efficacy, antagonist binding also has both affinity and efficacy.

A. True
B. False

B

15

If spare receptors are present, the agonist can still reach maximum effect in the presence of noncompetitive antagonist.

A. True
B. False

A

16

The first step in the clinical phase drug discovery involves

A. Animal studies
B. In vitro screening
C. Human trials
D. Bioavailability

C

17

Ranitidine was discovered by:

A. random testing
B. chemical modification
C. Serendipity
D. Rational drug design

B

18

A set of standard guidelines in the conduct of human clinical trials

A. GLP
B. GCP
C. GNP
D. IND

B

19

Phase 2 clinical trials mean:

A. The candidate drug is given to thousands of volunteers
B. The candidate drug is tested among patients with disease of interest
C. The candidate drug is tested in 2 rodents and 1 primate
D. The candidate drug undergoes a sequence of chemical modifications for optimization

B

20

The phase that answers the question “how does a candidate drug fare compared to the standard?”

A. Phase 1
B. Phase 2
C. Phase 3
D. Phase 4

C

21

Pharmacogenomics is the branch of pharmocology that

a. uses the application of genomic technology to the study of drug discovery, pharmacological function, disposition and therapeutic response
b. operates on the principle of “not one size fits all”
c. emphasizes the importance of individualizing drug therapy for different patient who may have common disorders
d. aota
e. a and c

E

22

The log-dose effect relationship shows:

a. a hyperbolic curve
b. a sigmoid curve
c. the four characteristics – potency, efficacy, slope and variability
d. a and c
e. b and c

E

23

Classes of drugs are best described according to:

a. source whether natural or synthetic
b. chemical structure
c. therapeutic use and therapeutic effect
d. all of the above
e. b and c

C

24

While receptors regulate biochemical and physiological activity, they are themselves subject to regulatory and homeostatic controls like

a. upregulation due to continued stimulation of cells with agonists
b. down regulation due to covalent bonding or relocalization or destruction of receptors
c. upregulation due to synthesis of new receptors
d. aota
e. b and c

E

25

True of competitive and noncompetitive agonists

a. reversible and irreversible respectively
b. have intrinsic activity only
c. have affinity only
d. have both affinity and intrinsic activity
e. a and d

E

26

The most important properties of any drug product is/are:

a. efficacy and safety
b. efficacy, safety and quality
c. efficacy, potency and safety
d. cost, efficacy, potency, safety, quality

B

27

The Quantal dose response curve has the following:

a. usually a Gaussian/ normal curve
b. always shows dose and response
c. affected by frequency, rate and dose of drug
d. describes low, middle, and high dose
e. all of the above

E

28

Margin of safety is measured by

a. Therapeutic index which is the ration of toxic dose 50 over effective dose 50
b. Standard safety margin utilizing 100 experimental animals
c. Standard safety margin utilizing 1000 experimental animals
d. Distance between the minimum effective dose and the maximum effective dose which is just a hairline away from the minimum toxic dose
E. AOTA

E

29

Of all the different kinds of adverse effects, one or all of those listed below that can be desirable depending on the circumstances surrounding the patient

a. idiosyncracy
b. tolerance
c. side effect
d. tachyphylaxis
e. all of the above

C

30

Definition of pharmacokinetics

A. What the living body does to the drug
B. What the drug does to the body
C. Sum total of absorption, distribution, metabolism and excretion
D. A and B
E. B and C

A or C