SARS

Question 1

SARS

Answer 1

severe acute respiratory syndrome

Question 2

When and where did sars first appear

Answer 2

china in november 2002

Question 3

what was observed in the guangdong province in november 2002

Answer 3

highly contagious and severe atypical pneumonia

Question 4

what did highly contagious and severe atypical pneumonia involve

Answer 4

cells dying causing gas exhange to go down

Question 5

what places were considered hot zones for SARS

Answer 5

vietnam, hong kong, singapore, toronto, china

Question 6

when did the world health organization issue a worldwide disease alert

Answer 6

March 15th 2003

Question 7

When was SARs found in Hong kong

Answer 7

February 2003

Question 8

what are normal oxygen stats?

Answer 8

100-98%

Question 9

what were the oxygen stats of one with SARS

Answer 9

80-70%

Question 10

what was the mortality rate for SARS

Answer 10

4%

Question 11

what is SARS caused by

Answer 11

coronavirus

Question 12

when was the first coronavirus isolated

Answer 12

1937 from chickens

Question 13

symptoms of SARS

Answer 13

-fever of 100.5 degrees
-persistent dry cough
-malaise and body aches
-shortness of breath
-cytokine storm

Question 14

cytokine storm

Answer 14

overproduction of cytokines

Question 15

what is the incubation period of SARS

Answer 15

roughly 6 days

Question 16

what is the time period from exposure to onset of symptoms

Answer 16

2-16 days

Question 17

when does one infected with SARS usually require intensive care

Answer 17

about 10 days after onset of symptoms

Question 18

week 1 of sars

Answer 18

cold like symptoms, fever, myalgia, chills, sore throat

Question 19

week 2 of sars

Answer 19

recurrence of fever, onset of diarrhea, oxygen desaturation

Question 20

what percent reaches the 3rd phase of SARs

Answer 20

20%

Question 21

what does the 3rd phase require

Answer 21

a ventilation system

Question 22

what is the fatality rate upon infection

Answer 22

about 10%

Question 23

how long can SARS survive outside the body on a dry surface

Answer 23

3-4 hours

Question 24

what is the main vector of SARS

Answer 24

water droplets

Question 25

what can SARS be spread by

Answer 25

any body fluid contact

Question 26

what is SARS natural host

Answer 26

masked palm civet

Question 27

how many species of the masked palm civet were found to harbor SARS

Answer 27

6

Question 28

what is considered the SARS natural reservoir host

Answer 28

horseshoe bats

Question 29

what are members of the coronavirus family that are relative of SARS

Answer 29

bovine coronavirus murine hepatitis virus avian bronchitis virus porcine diarrhea virus

Question 30

SARS has no

Answer 30

vaccine

Question 31

Viral genome structure

Answer 31

The non-segmented RNA genome has 5’ cap and 3’ poly A tail Genome size ranging from 27 to 32 kb contains 6 ORFs Monocistronic mRNA The virions is about 100 to 140 nm in diameter

Question 32

viral protein structure

Answer 32

Pleomorophic and enveloped particles Characteristic long projected surface protein (spike) about 20 nm long

Question 33

SARS is less likely to spread

Answer 33

via fecal or airborne -viral load is peaked at around 10 days and 13-14 days in stool

Question 34

superspreader

Answer 34

infectivity of a large population by major viral shedding by patients due to high concentration of virus -singpore epidemic

Question 35

components of SARS isolation

Answer 35

-facility charactristics

Question 36

components of SARS isolation

Answer 36

-facility característics -administrative controls -organization of isolation area -protective attrie -hand hygiene -cleaning and disinfection -waste and linen handing

Question 37

MERS-Cov

Answer 37

middle east respiratory syndrome coronavirus -enveloped positive strand RNA virus

Question 38

what is the mortality rate of MERS

Answer 38

appox 50%

Question 39

6 human CoVs9 HCovs)

Answer 39

-HCoV-229E – HCoV-OC43 – HCoV-NL63 – HCoV-HKU1 – SARS-CoV – Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

Question 40

where is when was MERS-CoV first reported?

Answer 40

april 13th 2012 60 year old saudi man experiecning 7 day fever and cough