SARS-CoV-2

Question 1

-the diversity of coronavirus
-are MERS and SARS-CoV seasonal or non-seasonal

Answer 1

cornonvirus is present is large range and diverse animal species through cross species transmission

-these viruses are not seasonal
every other virus is seasonal

Question 2

unique feature of SARS-CoV-2
-what makes it more infecious
-unusual genome of virus

Answer 2

furin cleavage fite- makes virus more infectious
-17th coroanvirus
-unusually large +ssRNA virus for replication

Question 3

what allows virus transmission to occur between species

Answer 3

-suitable receptors
-overcome immune response

Question 4

transmission of SARS-CoV-2
-what impacts transmission

Answer 4

respiritory virus
-temperature and humidity

Question 5

the 4 stages of viral entry of genome

Answer 5

1) binding
2) insertion
3) cleavage
4) fusion

Question 6

SARS-CoV-2 vaccines
1) genetic vaccines
2) viral vector vaccines
3) inactivated vaccine
4) attenuated vaccine
5) protein vaccines e.g. cocovax

Answer 6

1) contains DNA or mRNA
2) contains modified genetic material
3) still have virus but it’s killed
4) weakened SARS-CoV-2 virus. if weak immune response you can get symptoms
5) make protein spike and inject it into you

Question 7

timing problem of SARS-CoV-2 antiviral drugs

Answer 7

new antiviral drugs are identified but need to be administered before the severe illness phase (when viral replication is nearly over).
during hospitalisation treatment should focus less on antiviral.

Question 8

The cellular receptor used by both SARS-CoV-1 and SARS-CoV-2 for cellular entry is:

Answer 8

angiotension converting enzyme 2

Question 9

the difference between SARS Cov 2 and
SARS cov 1 and MERS cov

-

Answer 9

sars cov 2 is similair but less severe and more aymptomatic cases