SAS 6

Question 1

is a PGE1 that is naturally produced in tissues *used for ductus arteriosus in fetus

Answer 1

Alprostadil

Question 2

is a PGE1 derivative that is used primarily for constipation cases

*also used in IBS

Answer 2

Lubiprostone

Question 3

is methyl analog of PGE1 that creates barrier in GI but is also used with NSAIDS to prevent GI problems

Answer 3

Misoprostol

Question 4

BimatoPROST, LatanoPROST, TafluPROST, travaPROST is a?

Answer 4

an analog of PGD F2a

Question 5

Epoprostenol is a?

Answer 5

naturally occurring prostacyclin

Question 6

Iloprost and treprotenil is a?

Answer 6

synthethic analog of prostacyclin

Question 7

What are the non-selective NSAIDs? (5)

Answer 7

Indomethacin, Aspirin, Sulindac, Meclofenamate, Ibuprofen

Question 8

What are the selective COX-2 inhibitors? (8)

Answer 8

Celecoxib, Meloxicam, Etodolac, Valdecoxib, Rofecoxib, Lumiracoxib, Etoricoxib, Diclofenac

Question 9

/ anti-platelet effect that last 8-10 days and 6-12 hours in tissues that replaces COX enzyme

Answer 9

Aspirin

Question 10

relatively equal to aspirin but LACKS INFLAMMATORY PROPERTY

Answer 10

Acetaminophen

Question 11

an NSAIDs promoted systemically and is used for short-term

Answer 11

Ketorolac

Question 12

an NSAIDS that inhibits re-uptake of NET and 5-HT

Answer 12

Tramadol

Question 13

preferentially inhibits COX 2

Answer 13

Meloxicam

Question 14

How long will it take for DMARDS to take effect?

Answer 14

2w. - 6 months

Question 15

it inhibits Thymidylate synthase and AICAR Transformylase

Answer 15

Methotrexate

Question 16

what is the effect of Methotrexate?

Answer 16

inhibition of cytokine production and biosynthesis of purine nucleotide

Question 17

this lessens methotrexate adverse effect?

Answer 17

Leucovorin

Question 18

a tetracycline antibiotic that is considered DMARDS

Answer 18

Minocycline

Question 19

it’s active metabolites are 5-aminosalicylate-inflammatory bowel disease & Sulfapyridine RA

Answer 19

Sulfasalazine

Question 20

use as a bridge until DMARDS take effect

Answer 20

Glucocorticoid

Question 21

What are the IL-1 inhibitors?

Answer 21

Rilonacept, Anakinra, Canakinumab

Question 22

T-cell depleting

Answer 22

Abatacept

Question 23

IL-6 inhibitor

Answer 23

Tocilizumab

Question 24

URIC ACID: retrieved from autumn crocus and cholchicum autumnale

Answer 24

Colchicine

Question 25

inhibits polymerization of protein tubulin into microtubles

Answer 25

Colchicine

Question 26

Standard-of-care to gout

Answer 26

Allopurinol

Question 27

Non-purine xanthine inhibitor

Answer 27

Febuxostat

Question 28

metabolized into alloxanthine by xanthase oxidase and then reversibly inhibits xanthine oxidase

Answer 28

Allopurinol

Question 29

• used for generalized anxiety stress
• Partial agonist at 5-HT but affinity to D2 is also possible

Answer 29

Busiprone

Question 30

inhibited by grape juice

Answer 30

Suvorexant

Question 31

preferentially arrest lymphocytes

Answer 31

Leflunomide