Section 3 - Quiz Questions

Question 1

**Match each drug with the appropiate receptor type that mediates the effects on which its medical use is based. **

Atenolol

Pilocarpine

Pancuronium

Prazosin

Answer 1

Match each drug with the appropiate receptor type that mediates the effects on which its medical use is based.

Atenolol - Beta Adrenergic Receptor

Pilocarpine - Muscarinic Cholinergic Receptor

Pancuronium - Nicotinic Cholinergic Receptor

Prazosin - Alpha Adrenergic Receptor

Question 2

Choose the drug that produces these effects

Paralyzes skeletal muscle and inhibits respiration

Answer 2

Choose the drug that produces these effects

Paralyzes skeletal muscle and inhibits respiration

_Atracurium _

Question 3

Choose the drug that produces these effects

Can produce dry mouth and pupillary dilation

Answer 3

Choose the drug that produces these effects

Can produce dry mouth and pupillary dilation

Atropine

Question 4

Choose the drug that produces these effects

Increases heart rate and cardiac contractility

Answer 4

Choose the drug that produces these effects

Increases heart rate and cardiac contractility

Dobutamine

Question 5

Choose the drug that produces these effects

Produces salivation, lacrimation, urination and defecation

Answer 5

Choose the drug that produces these effects

Produces salivation, lacrimation, urination and defecation

Neostigmine

Question 6

Choose the drug that produces these effects

Decreases conduction in the atrio-ventricular node and inhibits ventricular tachyarrhthymias

Answer 6

Choose the drug that produces these effects

Decreases conduction in the atrio-ventricular node and inhibits ventricular tachyarrhthymias

Propanolol

Question 7

Which drugs are effective in abolishing a supraventricular tachyarrhthmia that is due to impulse re-entry in the AV node?

(2)

Answer 7

Which drugs are effective in abolishing a supraventricular tachyarrhthmia that is due to impulse re-entry in the AV node?

1. Propanolol (Class II AARD)
2. Dilitizaem (Class IV AARD)

Question 8

**Which class of anti-arrythmia drug lenthens the effective refractory period of centricular myocardial cells by slowing the retun of the ventricular action potential to the resting membrane potential? **

Answer 8

**Which class of anti-arrythmia drug lenthens the effective refractory period of centricular myocardial cells by slowing the retun of the ventricular action potential to the resting membrane potential? **

Class 3

Question 9

**Which drugs act directly at the sino-atrial node to increase heart rate? **

(2)

Answer 9

**Which drugs act directly at the sino-atrial node to increase heart rate? **

1. Atropine
2. Isoproterenol

Question 10

**Which type of cholinergic receptor mediates the effects of bethanechol in stimulating motility in the urinary bladder? **

Answer 10

**Which type of cholinergic receptor mediates the effects of bethanechol in stimulating motility in the urinary bladder? **

Muscarinic

Question 11

This drug produces sedation by stimulating a2- adrenergic receptors in the central nervous system.

Answer 11

This drug produces sedation by stimulating a2- adrenergic receptors in the central nervous system.

Medetomidine

Question 12

Which drug will relieve conduction block in the AV node?

Answer 12

Which drug will relieve conduction block in the AV node?

Atropine

Question 13

**Which drug will decrease blood pressure if injected after administration of the antihypertensive agent phentolamine? **

Answer 13

**Which drug will decrease blood pressure if injected after administration of the antihypertensive agent phentolamine? **

Isoproterenol

(stimulates all beta adrenergic receptors)

Question 14

Which cardiac receptor, when stimulated by an agonist, mediates a decrease in heart rate?

Answer 14

Which cardiac receptor, when stimulated by an agonist, mediates a decrease in heart rate?

M2-Muscarinic Cholinergic Receptor

(decrease pacemaker current in the SA node)

Question 15

Which drug acts as a competitive antagonist at beta1-adrenergic receptors?

Answer 15

Which drug acts as a competitive antagonist at beta1-adrenergic receptors?

Atenolol

(is a “cardio-selective” beta1-AR antagonist)

Question 16

What drug is used to correct urinary bladder atony (urinary retention)?

Answer 16

What drug is used to correct urinary bladder atony (urinary retention)?

Bethanechol

Question 17

Which drug is used to correct Myasthenia gravis (poor cholinergic neuromuscular signaling)?

Answer 17

Which drug is used to correct Myasthenia gravis (poor cholinergic neuromuscular signaling)?

Neostigmine

Question 18

Which drug is used to correct Bronchoconstrictive disease?

Answer 18

Which drug is used to correct Bronchoconstrictive disease?

Albuterol

Question 19

Which drug is used to correct Supraventricular tachyarrhythmia (rapid AV conduction with impulse re-entry)?

Answer 19

Which drug is used to correct Supraventricular tachyarrhythmia (rapid AV conduction with impulse re-entry)?

Propanolol

Question 20

**The vasorelaxant effects of acetylcholine are mediated by the intracellular second messenger ______ produced in the vascular SMOOTH muscle cells. **

Answer 20

**The vasorelaxant effects of acetylcholine are mediated by the intracellular second messenger ______ produced in the vascular SMOOTH muscle cells. **

Cyclic GMP

Question 21

**Which anti-arrhythmic drug is less effective in patients with hypokalemia or alkalosis? **

Answer 21

**Which anti-arrhythmic drug is less effective in patients with hypokalemia or alkalosis? **

Lidocaine

Question 22

Which receptors are coupled through G proteins to decreased adenylate cyclase activity and reduced cyclic AMP production?

(3)

Answer 22

Which receptors are coupled through G proteins to decreased adenylate cyclase activity and reduced cyclic AMP production?

Alpha2-Adrenergic Receptors

M2 Muscarinic Cholinergic Receptors

M4 Muscarinic Cholinergic Receptors

Question 23

**The first muscles to be paralyzed in a dog that received an effective dose of pancuronium (skeletal muscle relaxant) are those involved with: **

Answer 23

**The first muscles to be paralyzed in a dog that received an effective dose of pancuronium (skeletal muscle relaxant) are those involved with: **

Tail wagging

Question 24

When applied directly to the eyes, which type(s) of drug can decrease intraocular pressure, an action that is useful in treating patients with glaucoma?

**(2) **

Answer 24

When applied directly to the eyes, which type(s) of drug can decrease intraocular pressure, an action that is useful in treating patients with glaucoma?

1. Muscarinic Cholinergic Receptor Agonist
2. Beta1-Adrenergic Receptor Antagonist

Question 25

**Match the description with the drug that best fits** The skeletal muscle paralysis it produces can be reversed by neostigmine

Answer 25

**Match the description with the drug that best fits** ## Footnote The skeletal muscle paralysis it produces can be reversed by neostigmine **_Vecuronium_**

Question 26

**Match the description with the drug that best fits** It increases renal blood flow by acting at D1-dopamine receptors

Answer 26

**Match the description with the drug that best fits** ## Footnote It increases renal blood flow by acting at D1-dopamine receptors **_Fenoldopam _**

Question 27

**Match the description with the drug that best fits** ## Footnote It reverses the sedative and relaxant effects of xylazine (Rompun)

Answer 27

**Match the description with the drug that best fits** It reverses the sedative and relaxant effects of xylazine (Rompun) **_Atipamezole _**

Question 28

**Match the description with the drug that best fits** It stimulates, then desensitizes neuromuscular-type nicotinic cholinergic receptors

Answer 28

**Match the description with the drug that best fits** ## Footnote It stimulates, then desensitizes neuromuscular-type nicotinic cholinergic receptors **_Succinylcholine_**

Question 29

**Match the description with the drug that best fits** It inhibits both sympathetic and parasympathetic neurotransmission to peripheral organs.

Answer 29

**Match the description with the drug that best fits** ## Footnote It inhibits both sympathetic and parasympathetic neurotransmission to peripheral organs. **_Trimethaphan_**

Question 30

**Match the description with the drug that best fits** ## Footnote It slows heart rate and atrioventricular conduction by a direct action on cardiac neurotransmitter receptors

Answer 30

**Match the description with the drug that best fits** It slows heart rate and atrioventricular conduction by a direct action on cardiac neurotransmitter receptors **_Propanolol _**

Question 31

**Match the description with the drug that best fits** It stimulates all adrenergic receptors to increase cardiac output and systolic blood pressure, but decrease diastolic pressure

Answer 31

**Match the description with the drug that best fits** ## Footnote It stimulates all adrenergic receptors to increase cardiac output and systolic blood pressure, but decrease diastolic pressure **_Epinephrine_**

Question 32

**Match the description with the drug that best fits** ## Footnote It increases skeletal muscle blood flow and stimulates glycogenolysis in the liver

Answer 32

**Match the description with the drug that best fits** It increases skeletal muscle blood flow and stimulates glycogenolysis in the liver **_Clenbuterol _**

Question 33

**Which adverse effect of an acetylcholinesterase inhibitor is NOT prevented by the administration of atropine?**

Answer 33

**Which adverse effect of an acetylcholinesterase inhibitor is NOT prevented by the administration of atropine?** Skeletal Muscle Paralysis

Question 34

**Which AARD most effectively slows phase 0 of the ventricular action potential, especially in partially depolarized myocardial cells?**

Answer 34

**Which AARD most effectively slows phase 0 of the ventricular action potential, especially in partially depolarized myocardial cells?** Lidocaine

Question 35

**Which class of anti-arrhythmic drug lengthens the effective refractory period of ventricular myocardial cells by slowing the return of the ventricular action potential to the resting membrane potential?**

Answer 35

**Which class of anti-arrhythmic drug lengthens the effective refractory period of ventricular myocardial cells by slowing the return of the ventricular action potential to the resting membrane potential?** Class 3

Question 36

**Which drug will produce a baroreceptor reflex-associated increase in heart rate?**

Answer 36

**Which drug will produce a baroreceptor reflex-associated increase in heart rate?** Phentolamine

Question 37

**Which drug alleviates atrioventricular conduction block?**

Answer 37

**Which drug alleviates atrioventricular conduction block?** Atropine

Question 38

**At therapeutic doses, which drug increases cardiac contractility, i.e. has a positive ionotropic effect?**

Answer 38

**At therapeutic doses, which drug increases cardiac contractility, i.e. has a positive ionotropic effect?** Dobutamine

Question 39

**Which type of anticholinesterase drugs REVERSIBLY inhibits the catalytic activity of this enzyme by acting at the ESTERATIC site of acetylcholinesterase?**

Answer 39

**Which type of anticholinesterase drugs REVERSIBLY inhibits the catalytic activity of this enzyme by acting at the ESTERATIC site of acetylcholinesterase?** Carbamates (such as neostigmine)

Question 40

**Which drugs can dilate the pupil of the eye? ** (2)

Answer 40

**Which drugs can dilate the pupil of the eye?** 1. Phenylephrine 2. Atropine

Question 41

**What are 2 drugs that will cause pupillary constriction?**

Answer 41

**What are 2 drugs that will cause pupillary constriction?** 1. Betaxolol 2. Pilocarpine

Question 42

**Molecular target for each AARD** Sotalol

Answer 42

**Molecular target for each AARD** ## Footnote Sotalol **_Cardiac potassium channels _**

Question 43

**Molecular target for each AARD** Metoprolol

Answer 43

**Molecular target for each AARD** ## Footnote Metoprolol **_Cardiac beta1-adrenergic receptors _**

Question 44

**Molecular target for each AARD** ## Footnote Lidocaine

Answer 44

**Molecular target for each AARD** Lidocaine **_Cardiac sodium channels _**

Question 45

**Molecular target for each AARD** Diltiazem

Answer 45

**Molecular target for each AARD** ## Footnote Diltiazem **_Cardiac calcium channels _**