Student Generated Final Exam Questions Flashcards
(101 cards)
1. Which class of drugs should be used with caution in cats?
A) NSAIDS
B) Glucocorticoids
C) Diuretics
D) A and B
1. Which class of drugs should be used with caution in cats?
A) NSAIDS
B) Glucocorticoids
C) Diuretics
D) A and B
2. A dog is presented to you with a large open wound on its shoulder that is showing signs of infection. Which drug should NOT be given to this dog (may cause adverse effects)?
A) Epinephrine
B) Carprofen
C) Cortisol
D) Meloxicam
2. A dog is presented to you with a large open wound on its shoulder that is showing signs of infection. Which drug should NOT be given to this dog (may cause adverse effects)?
A) Epinephrine
B) Carprofen
C) Cortisol
D) Meloxicam
3. Which drugs should generally be avoided in a patient with GI ulcers?
A) A PGE derivative such as Misoprostil
B) A NSAID such as Flunixin
C) A glucocorticoid such as Prednisolone
D) B and C
3. Which drugs should generally be avoided in a patient with GI ulcers?
A) A PGE derivative such as Misoprostil
B) A NSAID such as Flunixin
C) A glucocorticoid such as Prednisolone
D) B and C
4. You diagnose glaucoma in your Shih Tzu patient “Gladiator.” Which drug(s) would you consider to reduce ocular pressure (i.e. to decrease intraocular fluid)?
A) Travoprost (a PGF2 derivative)
B) Pilocarpine (mAChR Agonist)
C) Betaxolol (β1-AR blocker)
D) All of the above
4. You diagnose glaucoma in your Shih Tzu patient “Gladiator.” Which drug(s) would you consider to reduce ocular pressure (i.e. to decrease intraocular fluid)?
A) Travoprost (a PGF2 derivative)
B) Pilocarpine (mAChR Agonist)
C) Betaxolol (β1-AR blocker)
D) All of the above
5. Why is acetaminophen not used as an anti-inflammatory in veterinary medicine?
a. Liver Phase I biotransformation converts it from an active drug to a toxic metabolite.
b. No anti-inflammatory properties at therapeutic range.
c. Eliminated slowly in cats due to cat’s poor phase II biotransformation ability, but quickly in ruminants.
d. All of the above.
5. Why is acetaminophen not used as an anti-inflammatory in veterinary medicine?
a. Liver Phase I biotransformation converts it from an active drug to a toxic metabolite.
b. No anti-inflammatory properties at therapeutic range.
c. Eliminated slowly in cats due to cat’s poor phase II biotransformation ability, but quickly in ruminants.
* *d. All of the above.**
6. Spironolactone is a mineralocorticoid antagonist and thus inhibits aldosterone activity. This drug, especially when combined with loop or thiazide diuretics, can help manage symptoms of the following condition:
a. Congestive heart failure.
b. Hyperaldosteronism.
c. Tachyarrhythmias.
d. Acute or chronic renal failure
6. Spironolactone is a mineralocorticoid antagonist and thus inhibits aldosterone activity. This drug, especially when combined with loop or thiazide diuretics, can help manage symptoms of the following condition:
- *a. Congestive heart failure.**
b. Hyperaldosteronism.
c. Tachyarrhythmias.
d. Acute or chronic renal failure
7. Which one of the following statements on nutrient mobilization is correct?
a. B2-Adrenergic receptor stimulation causes an increase in glycogenolysis and a decrease in glucose uptake into tissues (hyperglycemic effect).
b. Glucocorticoids increase lipase activity and fat mobilization leading to increased serum levels of free fatty acids.
c. B3-Adrenergic receptor stimulation causes an increase in triglyceride lipase activity in fat cells and an increase in free fatty acids in blood (lipolytic effect).
d. Glucocorticoids increase liver glucose uptake, gluconeogenesis, and glycogen storage, while decreasing glucose utilization everywhere else in the body.
e. All of the above statements are correct.
7. Which one of the following statements on nutrient mobilization is correct?
a. B2-Adrenergic receptor stimulation causes an increase in glycogenolysis and a decrease in glucose uptake into tissues (hyperglycemic effect).
b. Glucocorticoids increase lipase activity and fat mobilization leading to increased serum levels of free fatty acids.
c. B3-Adrenergic receptor stimulation causes an increase in triglyceride lipase activity in fat cells and an increase in free fatty acids in blood (lipolytic effect).
d. Glucocorticoids increase liver glucose uptake, gluconeogenesis, and glycogen storage, while decreasing glucose utilization everywhere else in the body.
* *e. All of the above statements are correct.**
Which of the following statements about Lidocaine is incorrect?
a. Lidocaine is a Class IB antiarrhythmic drug that binds to open and inactivated Na+ channels.
b. Lidocaine inhibits intestinal motility.
c. Lidocaine decreases automaticity, especially in damaged Purkinje fibers.
d. The mechanism of action of Lidocaine in the gastrointestinal tract is unclear.
Which of the following statements about Lidocaine is incorrect?
a. Lidocaine is a Class IB antiarrhythmic drug that binds to open and inactivated Na+ channels.
* *b. Lidocaine inhibits intestinal motility.**
c. Lidocaine decreases automaticity, especially in damaged Purkinje fibers.
d. The mechanism of action of Lidocaine in the gastrointestinal tract is unclear.
9. Which of these is NOT a G-protein coupled receptor?
A. Histamine receptors
B. Adrenergic receptors
C. Dopamine receptors
D. Mineralcorticoid receptors
9. Which of these is NOT a G-protein coupled receptor?
A. Histamine receptors
B. Adrenergic receptors
C. Dopamine receptors
D. Mineralcorticoid receptors
- *10. Which of these drugs have sedative effects?
1. Hydroxyzine
2. Methylxanthine
3. Scopolamine
4. Acetazolamide**
A. A
B. A, B
C. A, C
D. All of the drugs
- *10. Which of these drugs have sedative effects?
1. Hydroxyzine
2. Methylxanthine
3. Scopolamine
4. Acetazolamide**
A. A
B. A, B
C. A, C
D. All of the drugs
11. You’re called to a dairy farm to examine the family’s best producer, Bessie. Upon examination, you determine that Bessie is having heart problems, ventricular tachyarrhythmia to be exact. You decide that you’d like to prescribe a drug that will depress phase 0 of the action potential and decrease conduction velocity of the heart, but the farmer is worried about accumulation in the milk. Which of the following is your best treatment option?
A. Class II AARD, pH>6.8
B. Class I AARD, pH>6.8
C. Class III AARD, pH<6.8
D. Class I AARD, pH<6.8
11. You’re called to a dairy farm to examine the family’s best producer, Bessie. Upon examination, you determine that Bessie is having heart problems, ventricular tachyarrhythmia to be exact. You decide that you’d like to prescribe a drug that will depress phase 0 of the action potential and decrease conduction velocity of the heart, but the farmer is worried about accumulation in the milk. Which of the following is your best treatment option?
A. Class II AARD, pH>6.8
B. Class I AARD, pH>6.8
C. Class III AARD, pH<6.8
D. Class I AARD, pH<6.8
** Many drugs in different classes share the ability to affect similar pharmacological pathways and cause similar affects. Glucocorticoids for instance share their ability to block the formation of prostanoids with ______1__________ by blocking Cyclooxygenase; they also have a similar affect as _______2_________ in causing hyperglycemia. Which one of the following options best completes the above statement?**
A. Blank 1: NSAIDS, Blank 2: B-Adrenergic Agonists
B. Blank 1: Mineralocorticoids, Blank 2: NSAIDS
C. Blank 1: B-Adrenergic Antagonists, Blank 2: NSAIDS
D. Blank 1: NSAIDS, Blank 2: B-Adrenergic Antagonists
Many drugs in different classes share the ability to affect similar pharmacological pathways and cause similar affects. Glucocorticoids for instance share their ability to block the formation of prostanoids with ______1__________ by blocking Cyclooxygenase; they also have a similar affect as _______2_________ in causing hyperglycemia. Which one of the following options best completes the above statement?
A. Blank 1: NSAIDS, Blank 2: B-Adrenergic Agonists
B. Blank 1: Mineralocorticoids, Blank 2: NSAIDS
C. Blank 1: B-Adrenergic Antagonists, Blank 2: NSAIDS
D. Blank 1: NSAIDS, Blank 2: B-Adrenergic Antagonists
Which H1-histamine antagonist acts as both an anti-emetic and an 1st generation anti-histamine?
Benadryl (diphenhydramine)
Zofran (Odansetron)
Cetirizine (Zyrtec)
Loratidine (Claritin)
Which H1-histamine antagonist acts as both an anti-emetic and an 1st generation anti-histamine?
Benadryl (diphenhydramine)
Zofran (Odansetron)
Cetirizine (Zyrtec)
Loratidine (Claritin)
Lidocaine blocks voltage-gated Na+ channels in which location(s)?
Purkinje Fibers
Ventricles
Enteric Nerves
All of the above
Lidocaine blocks voltage-gated Na+ channels in which location(s)?
Purkinje Fibers
Ventricles
Enteric Nerves
All of the above
NSAIDs can inhibit all of the following enzymes directly for pharmacological control of eicosanoid synthesis except:
a. Cyclooxygenases
b. Lipoxygenases
c. Phospholipase A2
d. All of the above are inhibited by NSAIDs
NSAIDs can inhibit all of the following enzymes directly for pharmacological control of eicosanoid synthesis except:
a. Cyclooxygenases
b. Lipoxygenases
* *c. Phospholipase A2**
d. All of the above are inhibited by NSAIDs
- *Which are side effects of Glucocorticoids (vs. the side effects of NSAIDS)**
a. 1,2,4,5,6
b. 1,4,6
c. 2,3,5
d. none of the below are Glucocorticoid side effects - *1. Uterine contractions decreased
2. Muscle weakness/wasting from hypocalcemia
3. Hypertension from increased Na+ retention
4. Intestinal Ulcers
5. Hyperglycemia
6. Blood clotting alterations**
- *Which are side effects of Glucocorticoids (vs. the side effects of NSAIDS)**
a. 1,2,4,5,6
b. 1,4,6 - *c. 2,3,5**
d. none of the below are Glucocorticoid side effects - *1. Uterine contractions decreased
2. Muscle weakness/wasting from hypocalcemia
3. Hypertension from increased Na+ retention
4. Intestinal Ulcers
5. Hyperglycemia
6. Blood clotting alterations**
Match each clinical indication below with the drug that would be most appropriate to use. Each drug may be used only once.
- Non-productive cough
- Systemic Anaphylaxis
- Atonic Bladder
- Ventricular Tachyarrhythmia
- Gastric Ulcer
a) Lidocaine
b) Omeprazole
c) Bethanechol
d) Epinephrine
e) Butorphanol
Match each clinical indication below with the drug that would be most appropriate to use. Each drug may be used only once.
ANSWER:
- Non-productive cough = E) Butorphanol
- Systemic Anaphylaxis = D) Epinephrine
- Atonic Bladder = C) Bethanechol
- Ventricular Tachyarrhythmia = A) Lidocaine
- Gastric Ulcer = B) Omeprazole
Which class of drugs is likely to produce side-effects characterized by SLUD syndrome if overdosed?
A) H1-Antihistamines
B) Glucocorticoids
C) Adrenergic Agonists
D) Cholinergic Agonists
Which class of drugs is likely to produce side-effects characterized by SLUD syndrome if overdosed?
A) H1-Antihistamines
B) Glucocorticoids
C) Adrenergic Agonists
D) Cholinergic Agonists
Match the drug with its correct action.
- Lidocaine
- Propanolol
- Sotalol
- Diltiazem
A. K+ Channel Blocker
B. Na+ Channel Blocker
C. Ca2+ Channel Blocker
D. B-Adrenergic Antagonist
Match the drug with its correct action
Lidocaine - Na+ Channel Blocker
Propanolol - B-Adrenergic Antagonist
Sotalol - K+ Channel Blocker
Diltiazem - Ca2+ Channel Blocker
Please match the type of drug with the indicated use. Use each answer only once.
β2-Adrenergic Agonist (Albuterol)
H1-Histamine Antagonist (Loratidine)
ACE inhibitor (Enalapril)
H2-Histamine Antagonist (Famotidine)
*Bronchodilation
Gastric Ulcer Prevention
Allergic Disease
Congestive Heart Failure *
Please match the type of drug with the indicated use. Use each answer only once.
β2-Adrenergic Agonist (Albuterol) - *Bronchodilation *
H1-Histamine Antagonist (Loratidine) - Allergic Disease
ACE inhibitor (Enalapril) - Congestive Heart Failure
H2-Histamine Antagonist (Famotidine) - *Gastric Ulcer Prevention *
Why do non-steroidal anti-inflammatory drugs (NSAIDs) have a low volume of distribution (Vd)?
a. They are acidic (ionized).
b. They bind extensively to plasma proteins.
c. They accumulate in inflamed areas.
d. All of the above
Why do non-steroidal anti-inflammatory drugs (NSAIDs) have a low volume of distribution (Vd)?
a. They are acidic (ionized).
b. They bind extensively to plasma proteins.
c. They accumulate in inflamed areas.
* *d. All of the above**
Triamterene and Spironolactone are _____ that undergo hepatic biotransformation to active metabolites. This activation occurs in _____ of hepatic biotransformation via oxidation, reduction, or hydrolysis.
a. calcineurin inhibitors; phase 1
b. diuretics; phase 1
c. calcineurin inhibitors; phase 2
d. diuretics; phase 2
Triamterene and Spironolactone are _____ that undergo hepatic biotransformation to active metabolites. This activation occurs in _____ of hepatic biotransformation via oxidation, reduction, or hydrolysis.
a. calcineurin inhibitors; phase 1
* *b. diuretics; phase 1**
c. calcineurin inhibitors; phase 2
d. diuretics; phase 2
23. Which of the following antihistamines would be most likely to produce a brain:plasma concentration ratio of < 1?
A. diphenhydramine
B. cetirizine
C. meclizine
D. chlorpheniramine
23. Which of the following antihistamines would be most likely to produce a brain:plasma concentration ratio of < 1?
A. diphenhydramine
B. cetirizine
C. meclizine
D. chlorpheniramine
What are the primary actions of glucocorticoid-glucocorticoid receptor (GC-GCR) complexes?
A. Decrease expression of pro-coagulant cytokines, and increase expression of anti-coagulant cytokines
B. Increase contractility in myocardial cells, and decrease Na+/K+/ATPase activity
C. Decrease expression of histamine H2 receptors, and increase production of prostaglandins
D. Decrease expression of pro-inflammatory proteins, and increase expression of anti-inflammatory proteins
What are the primary actions of glucocorticoid-glucocorticoid receptor (GC-GCR) complexes?
A. Decrease expression of pro-coagulant cytokines, and increase expression of anti-coagulant cytokines
B. Increase contractility in myocardial cells, and decrease Na+/K+/ATPase activity
C. Decrease expression of histamine H2 receptors, and increase production of prostaglandins
D. Decrease expression of pro-inflammatory proteins, and increase expression of anti-inflammatory proteins