Sensory Pathways: Touch and Proprioception Flashcards

(94 cards)

1
Q

What receptors are responsible for the sensory modalities of touch and proprioception?

A

Mechanoreceptors

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2
Q

Describe the structure of mechanoreceptors involved in touchand proprioception.

A

The receptor is NOT a separate entity but is actually the peripheral terminal of the peripheral axon of the primary sensory neuron.

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3
Q

What is the difference between slow adapting and fast adapting receptors?

A

Slow adapting receptors continue firing impulses for as long as thestimulus is present
Fast adapting receptors tend to fire at the start of the stimulus and sometimes when the stimulus switches off but they tend to fade in the middle

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4
Q

What type of receptors are mechanoreceptors?

A

Mixture of slow and fast adapting receptors

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5
Q

Describe how sensory neurons vary in their properties.

A

They vary in SIZE and CONDUCTION VELOCITY

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6
Q

What are the two classifications of axons?

A

Anatomical = based on axon diameter (labelled using LETTERS)
Physiological = based on conduction velocity (labelled using ROMAN NUMERALS)
As axon diameter and conduction velocity are related, there is a lot of overlap in the classifications

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7
Q

Describe the general structure of sensory neurons that convey touch and proprioceptive information.

A

They are LARGE and have a FAST conduction velocity

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8
Q

What is a receptive field?

A

An area of skin that is innervated by one sensory axon and its branches

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9
Q

Describe how the receptive fields in the lips and mouth vary from the receptive fields of the upper arm.

A

Lips and Mouth – high-density innervation with very small receptive fields
Upper arm – larger receptive fields and thinner innervation

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10
Q

Describe how neurons can code for the intensity of a stimulus.

A

It is coded by the FREQUENCY of the action potentials going down the sensory fibres

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11
Q

Which part of the spinal cord carries sensory axons for touch and proprioception?

A

Dorsal columns

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12
Q

What are the bundles of axons within the spinal cord that havecome from above and below the waist called? Describe their spatial arrangement within the spinal cord.

A
Above the waist – Cuneate Fasciculus 
Below the waist – Gracile Fasciculus  
Axons from below the waist are packed more medially in the dorsal column and above the waist are more lateral
Lower = Medial 
Higher = Lateral
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13
Q

Where do these fasiculus neurons synapse?

A

They synapse in the Cuneate and Gracile Nuclei in the medulla

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14
Q

Describe what happens after these fasiculus neurons synapse and the tract that they run in.

A

The second order neurons then cross the midline (decussation) and continue up the brainstem in the MEDIAL LEMNISCUS

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15
Q

Which thalamic nucleus is responsible for relaying somatosensory information from the neck down?

A

Ventral Postero-lateral

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16
Q

Describe the passage of the third order sensory neuron.

A

The third order neurone travels from the ventral postero-lateral nucleus in the thalamus to the primary somatosensory cortex

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17
Q

What is the main sensory nerve of the face?

A

Trigeminal Nerve (CN V)

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18
Q

Where does the trigeminal nerve enter the brainstem and where does it synapse with a second order neuron?

A

Pons

It synapses at the trigeminal cranial nucleus

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19
Q

Describe the passage of the trigeminal sensory second order neuron.

A

The second order neuron crosses the midline (decussation) and joins the medial part of the median lemniscus

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20
Q

Which thalamic nucleus is responsible for relaying sensory information from the face?

A

Ventral Postero-medial

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21
Q

What is lateral inhibition?

A

Lateral inhibition takes place in the cuneate and gracile nuclei
Each axon has lateral branches that are inhibitory on neighbouringaxons
So each axon will stimulate a second order neuron and inhibit neighboring first order neurons

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22
Q

What is the purpose of lateral inhibition?

A

Improves the resolution of localising the stimulus

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23
Q

Name the three parts of the somatosensory cortex.

A

Primary Somatosensory Cortex (SI)
Secondary Somatosensory Cortex (SII)
Posterior Parietal Cortex

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24
Q

What is the posterior parietal cortex mainly involved in?

A

Spatial relationships

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25
Damage to the touch and proprioception pathway will halt sensory information going up to the primary somatosensory cortex. What effects will this have?
Anaesthesia (complete cessation of sensation) | Parasthesia (sensation is there but it isn’t normal)
26
What is the most common cause of peripheral neuropathy?
Diabetes mellitus
27
List 4 major somatosensory modalities
Pain Temperature Touch Proprioception
28
3 sensory neurones
A beta A delta C fibers
29
Define receptor
Transducers that convert environmental energy to neuronal action potentials
30
What is somatosensory function?
``` Ability to interpret the bodily sensations Mechanical Thermal Proprioceptive Nociceptive ```
31
Somatosensory system consists of
Receptors Nerve cell tracts in body and spine Parts of brain dealing with processing sensory information
32
Somatosensory modalities
Touch- mechanical stimuli Thermal Nociception Proprioception
33
What is modified to determine what is being sensed
Nerve terminal
34
What do free nerve endings transduce
Nociceptors and thermoreceptors
35
What do enclosed nerve terminals transduce
Mechanoreceptors
36
Role of AB fibres
Innocuous mechanical stimulation | The fastest
37
Role of A delta fibres
Noxious mechanical and thermal stimulation
38
Role of c fibres
Noxious mechanical, thermal and itch stimulation
39
Define receptors
Sensory receptors are transducers that convert environmental energy to neuronal action potentials
40
Thermoreceptor fibres
A delta and C
41
How do nerves determine temperature changes
Presence of Transient Receptor potential ion channels | 4 heat activated and 2 cold activated ion channels which are activated by different temperatures
42
5 different mechanoreceptors
``` Hair follicle receptors Meissners corpuscle Merkel cells Pacinian corpuscle Ruffini endings ```
43
Role of meissners corpuscles
Transduce low frequency vibration and fine discriminative touch
44
Role of Merkel cells
Transduce light touch and superficial pressure
45
Role of pacinian corpuscles
Transduce deep pressure High frequency vibration Tickling
46
Role of ruffini endings
Transduce continuous pressure | Stretch
47
Role of hair follicle receptors
Light touch
48
Phasic receptors
Detect change in stimulus strength by transmitting impusle at start and end of a stimulus so when a change has occurred
49
Example of phasic receptor
Pacinian receptor | Sudden pressure when excited then transmits signal when pressure released
50
Feature of phasic receptor
Fast adapting
51
Receptive field
Region of skin which causes activation of one signal sensory neurone
52
Differences in receptor fields across body
On back is large fields so cells detect over a larger area for less precise perception Whereas on fingers are densely packed mechanoreceptors with small receptor fields giving very precise perception
53
2 point discrimination
Minimum distance at which 2 points are perceived as separate
54
What is 2 point discrimination related to
Size of receptive field
55
Where are cell bodies for receptors in body
Dorsal root ganglia at that spinal level
56
Where are cell bodies for receptors found on face
Trigeminal ganglia
57
Pathway for sensory information from upper limbs
Received at cervical level-> head up cuneate fasiculas tract (known as internal arculate fibres) then cross over at medulla-> form medial lemniscus tract-> thalamus
58
Types of dorsal horn neurones
Axons that project to brain | Axons remaining in spinal chord (interneurones)
59
Difference in distribution sensory neurones synapsing in dorsal horn
A delta and c more superficial | A beta deeper
60
What is lateral inhibition
Can get overlapping of adjacent receptive fields making it hard to distinguish 2 stimulus locations. Lateral inhibition prevents this
61
How does lateral inhibition work
Mediated by inhibitory interneuones within dorsal horn
62
What pathway is touch and proprioception carried in
Dorsal column
63
Path of first order neurones touch and proprioception
Cell body in dorsal root ganglion, travels up either cuneate or gracile tract to terminate in either cuneate or gracile nucleus in medulla
64
Path of second order neurones
Decussate in caudal medulla then form contralateral medial leminiscus tract and synapse in the ventral posterior lateral nucleus
65
Differences in termination of second order neurones depending on where they’ve come from
Lower parts of body are more lateral
66
Somatosensory homunculus
Size of somatotropic area in brain is proportional to density of sensory receptors in that area
67
Differences in localisation between noxious and inoxious
Inoxious much more precise localisation
68
Location of somatosensory cortex
Found in posterior part of parietal lobe behind central gyrus
69
Differences in ascension between pain, temperature and crude touch
Crude touch in anterior spinothalamic | Pain and temp in lateral spinothalamic
70
Pathway of spinothalamic first order neurones
Terminate immediately in dorsal horn
71
Pathway second order spinothalamic pathway neurones
Decussate at spinal level and travel in lateral or anterior spinothalamic tract before terminating in VPL in thalamus
72
Topographic representation of body in VPL spinothalamic pathway
Lower extremities more lateral
73
Quantitive sensory testing purpose
To test effectiveness of spinal tracts
74
How quantitive sensory testing works
An quantified stimulus is applied either in form of heat and temperature for spinothalamic tract or 2 point stimulus for dorsal column and integrity is checked
75
Cause of anterior spinal lesion
Blocked anterior spinal artery
76
Effect on both tracts of anterior spinal artery blockage
Bilateral loss pain and temperate sensation below that spinal level Normal touch and 2 point discrimination below that level
77
Define pain
An unpleasant sensory or emotional experience associated with actual or potential tissue damage
78
2 types of nociceptors
A delta and C
79
Pain from a delta nociceptors
Sharp and intense first pain Type 1- noxious mechanical Type 2- noxious heat
80
Pain from c fibre nociceptors
Dull and aching pain from all stimuli
81
Spinal chord nociceptive processing NT
Glutamate is major pain signalling NT | It is released from sensory afferents in response to acute or persistent noxious stimuli
82
First synapse in pain pathway
Gulatmergic synapse in superficial dorsal horn
83
Parts of brain involved in pain reception
Amygdala Prefrontal cortex Cerebellum
84
Gate control theory
There is inhibition of primary afferent inputs to brain via a beta neurone which excites and inhibitory neurone
85
Descending control pathways
Use of strong emotions to inhibit pain
86
How does descending control pathways work
Monoamines from descending pathways can inhibit nociceptive processing in the dorsal horn
87
Examples of monoamines acting in descending control pathways
Serotonin and noradrenaline
88
Chronic pain
Pain experienced for over 3 months | In the uk believed 28 million people
89
Difference between nociceptive and neuropathic pain
Nociceptive to do with noxious stimulation of a somatic or visceral nociceptor but neuropathic a disease of somatosensory system
90
Peripheral sensitisation
With tissue damage a lot of inflammatory molecules are released, these have been proven to increase the sensitivity of nociceptors in this area therefore reducing their threshold for stimuli
91
Central sensitisation
Increased sensitisation of c fibres from periphery brings about a plasticity in the projection neurone in dorsal horn which affects adjacent cells such as the a delta fibre in dorsal horn
92
Allodynia
Pain due to a stimulus that does not normally provoke pain
93
Hyperalgaesia
Increased pain from a stimulus that does normally provoke pain
94
Remembering 5 mechanoreceptors
PHRMM