Sensory Systems Flashcards

(189 cards)

1
Q

Central nervous system in vertebrates

A

> 95% of 116 genes involved in brain or neural Morphogenesis were commonly shared among all vertebrates
30% of planarian nervous system-related genes are homologous sequences in Arabidopsis and yeast- which do not posses a nervous system

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2
Q

Dendrites

A

Conduct electric excitation in a directed way

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3
Q

Axon

A

A long, slender projection of a neuron that conducts electrical impulses away from the neuron’s cell body- transmit information to different neurons, muscles and glands
Myelinated axons = nerve fibres

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4
Q

Brain

A

A cluster of specialised groups of neurons
Most prominent anterior condensation of neurons

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5
Q

Nerve cord

A

Cluster of neurons
Most prominent longitudinally extending condensed part of the nervous system

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6
Q

How does the nerve cord run in invertebrates

A

Ventrally

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7
Q

How does the nerve cord run in vertebrates

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Dorsally

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8
Q

Ganglion

A

Group of specialised neurons
Parts of CNS
Neuronal somata concentrated at the surface - forming a cell cortex
Neurites are concentrated in the centre of the ganglion to form the neuropil
Distinct unit

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9
Q

Which animals do not have a centralised nerve system

A

Animals without bilateral symmetry eg Cnidarian

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10
Q

Cephalisation

A

The process by which nervous tissue, over many generations , becomes concentrated towards one end of the organism

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11
Q

Variation of CNS in chelicerata (arachnids)

A

Exhibit maximum concentration of the nervous system
Whole series of ganglia are aggregated together and fused (into one great central brain), from where nerves radiate to all parts of the body

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12
Q

Touch (tactile) receptors in Cnidarians

A

A simple nervous system , without brain, controls homeostasis
Eg nematocyst mechanism - If touched the hair triggers the cell explosion, a harpoon-like structure which attaches to organisms that trigger it and injects a dose of venom

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13
Q

PNS. Chordotonal organ- insects and crustaceans

A

Stretched neurons that detect different stimuli
Detection of vibration, touch receptors, chemoreceptors
Each unit consists of a sensory neuron, glial cells, scolopidal cells

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14
Q

Subcuticular mechanireceptors

A

Specialised sensory organs that receive vibrations in arthropods
Important for ground-dwelling species, especially nocturnal species

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15
Q

Subgenal organ

A

Complex ciliated mechanoreceptor below the knee in insects

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16
Q

Tricoid sensilla

A

Touch receptors on bodies of anthropods

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17
Q

Johnston organ

A

Largest mechanoreceptor organ of fruit fly
Gravity and sound detection

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18
Q

In invertebrates- where do tympanic ears occur

A

Insects

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19
Q

Vertebrate senses

A

Vision
Chemoreceptors (smell and taste)
Mechanoreceptirs (sound and other vibrations)
Electroreception
Magnetoreception
Temperature sensing

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20
Q

How do eyes vary

A

Acuity
Range of wavelengths they can detect
Sensitivity in low light levels
Ability to detect motion
Whether they can discriminate colour

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21
Q

Bird eyes

A

are able to perceived a wider range of light wavelengths than we can – in effect they can see ultra-violet light.
As mammals we tend to see eyes as being spherical but avian eyes vary in shape from being rather flattened to being bowed.
They also have a blood-rich pecten that protrude from the retina and is considered as a means of maximising nutrition to the eye.

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22
Q

Field of vision in prey

A

Wide possible view
Much of the angle is only viewed by one eye - monocular vision

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23
Q

Field of vision in predators

A

Stereopsis and depth perception
Binocular vision
Blind spot

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24
Q

Rods

A

Sensitive to low light
Rhodopsin

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25
Cones
Need brighter light Sensitive to various wavelengths Chromophore
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Colour vision
4 cone types - tetrachromatic eg birds 2 cone types - dichromatic eg macaque 1 cone type - monochromatic - colour blind eg dolphin 3 cone types - trichromatic eg humans
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Adaption to low light levels
High density of rods A ‘tapetum lucidum’ biological reflector system that is a common feature in the eyes of vertebrates. Functions to provide the light-sensitive retinal cells with a second opportunity for photon-photoreceptor stimulation, Enhances visual sensitivity at low light levels.
28
Chemoreception
Vertebrate chemoreception consists of taste, olfaction and the vomeronasal (or Jacobson’s) organ Olfaction involves detection of an airborne (or waterborne) molecule into a specific receptor on the surface of an olfactory sensory cell Taste involves detection of a waterborne molecule into a specific receptor on the surface of a taste bud
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Vomeronasal organ
Detects non-volatile chemical cues - Flehman’s response Linked to hypothalamus Used in the detection of pheromones (eg major urinary proteins in mice) Removal of the organ impairs sexual and social behaviour in rodents Snakes have a well developed paired Jacobson’s organs in the top of the buccal cavity. Molecules are collected by the wet tongue and then intorducted into the organ when the tongue is retracted
30
Mechanoreception
detects physical perturbations of the environment – the commonest are sound waves in the air (or water). (only mammals have true pinnae that focus sound waves down the ear canal). Sound waves going down the ear canal cause the ear drum to vibrate, which causes the ossicle bones to vibrate and transfer the sound waves to the cochlea. As the waves move through the fluid within the cochlea tiny hairs in the organ of Corti are disturbed, which generates nerve impulses which are perceived as sound.
31
Sound detection
The cochlea is filled with perilymph, - moves in response to the vibrations coming from the middle ear via the oval window As the fluid moves, the cochlear partition (basilar membrane and organ of Corti) moves Thousands of hair cells sense motion via their stereocilia, and convert that motion to electrical signals communicated via neurotransmitters to many thousands of nerve cells Hair cells in the organ of Corti are tuned to certain sound frequencies by way of their location in the cochlea
32
Fish mechanorecpetion system
In fish there is an otilith which resists movement from sound waves whilst the endolymph surrounding it moves – this causes hairs to be moved and triggers a nerve response. Fish lack any outer ear structure as their whole body can absorb sound waves.
33
Amphibian mechanorecpetion system
In amphibians there is a tympanic membrane on the side of the head (behind the eye) and this resonates and moves the columella – a bone that connects the tympanum to the otic capsule. Amphibians lack the semi-circular canals used in perceiving position as seen in mammals, crocodilians and birds.
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Evolution of sound detection
Fish No bony structure to transmit vibrations No Tympanum No middle ear Otoliths vibrate Frogs, Reptiles, Birds Single columella Straight cochlea Mammals External pinna Three middle ear ossicles Coiled Cochlea (except monotremes)
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Vibration detection - the lateral line
System of mechanosensory organs found in aquatic vertebrates, mainly fish but most amphibian larvae and some fully aquatic adult amphibians posses mechanosensitive systems comparable to the lateral line Provides information about flow patterns around animal and nearby objects Used to detect movement and vibration Provides spatial awareness and the ability to navigate in space Plays an essential role in orientation, foraging behaviour, and shoaling The major unit of functionality of the lateral line is the neuromast Superficial on surface of skin – respond to water motion Within canals – respond to pressure variations and gradients in adjacent cells
36
Electroreception
Electroreception is used in electro-location (detecting objects) and for electro-communication Passive – Animal senses the weak bioelectric fields generated by other animals and uses it to locate them (e.g. foraging) Active – Animal senses its surrounding environment by generating electric fields and detecting distortions in these fields using electroreceptor organs (e.g. communication)
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Ampullary receptors
located in skin sensitive to electrical fields of low frequency - <0.1 – 25 Hz) Found in many types of fish
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Tuberous receptors
in depressions in epidermis and covered by epidermal cells Sensitive to electrical fields of high frequency – 50 Hz – 2 kHz) Found in species that produce their own electrical fields and most sensitive to the frequencies produced by the fish
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Passive Electroreception
Animal senses the weak bioelectric fields generated by other animals and uses it to locate them (e.g. foraging)
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Active Electroreception
Animal senses its surrounding environment by generating electric fields and detecting distortions in these fields using electroreceptor organs (e.g. communication)
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Ampullae of Lorenzini
Electric field sensors of sharks Detect voltage differences Use electroreception to forage and possibly navigate
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Weakly electric fish
Use electroreception for mate attraction, territorial and agonisitic displays and mimicry Active electroreception has a range of about one body length
43
Magnetoreception
Allows an animal to detect a magnetic field to perceive direction, altitude or location. May underlie long-distance navigation in several animal species A method for animals to develop regional maps, e.g. of the Earth's magnetic field
44
Infrared sensing
Evolved independently in several different families of snakes It allows them to ‘see’ radiant heat at wavelengths between 5 and 30 μm Infrared light heats up parts of a thin membrane inside the pit organ, and TRPA1 proteins embedded on that membrane detect the temperature change Directional and sensitive Warm-blooded animals emit heat as infrared radiation Pit vipers can detect potential prey a meter away Accuracy enough to target vulnerable body parts of the prey Not only used for prey detection
45
Evolution of eyes
So the simplest ‘eye’ would be some photoreceptors in the epidermis (a) that sense the absence or presence of light. If the photoreceptors are then located within a depression in the epidermis (b) then the animal can determine whether light hitting the photoreceptors can come from a particular direction. If the gap through which light can travel is reduced to a ‘pin-hole’ (c) then a basic image can be projected on to the photoreceptors and offers finer directional perception. If the hole is covered by a transparent surface (d) then the space can be filled with a transparent humour. If a lens then develops next to the hole (e) then there is an ability to focus an image on the photo receptors. The final stage (f) sees the development of an iris that can actively regulate the amount of light entering the eye.
46
How does environment affect what colours of light you can see
ocean light penetration diminished quickly as you descend down the water column and the light wavelengths are filtered. Blue light extends furthest down and a full colour spectrum is only observable within a few metres of the surface.
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Tapetum lucidum
A reflector system that provides retinal cells with a second change at light detection- increasing light sensitivity in low light level
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Sound threshold
Lower thresholds = greater sensitivity to sound
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Sound detection in alligators
In air- more sensitive to low frequencies but less sensitive to high frequencies In water - more sensitive to all frequencies
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Mechanoreception in fish
No bony structure to transmit vibrations No tympanum No kiddle ear Otoliths vibrate
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Mechanoreception in fish, reptiles and birds
Single columella Straight cochlea
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Mechanoreception in mammals
External Pinna Three middle ear ossicles Coiled cochlea (except monotremes)
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Major unit of functionality of the lateral line
Neuromast - - superficial on surface of skin = respond to water motion - within canals = respond to pressure vibrations and gradients in adjacent cells
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How do birds carry out Magnetoreception
Through eyes Via iron deposits in the beak Through ears
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What is important for magnetoreception
Light Colour of light
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Sensory transduction
Sensory receptor cells convert stimulus energy into an electrical signal
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Ionotropic transduction
Receptor binds to a neurotransmitter and opens an ion channel across a cell membrane Ligand-gated channels
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Enlarged cell membrane of receptor cells
Increase surface area Increase receptor number
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2 types of transduction
Ionotropic Metabotropic
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Metabotropic transduction
Receptor molecule acts like a neurotransmitter to activate a metabotropic cascade Receptor protein activates a G protein, which activates a second effector molecule in the cell that then affects ion permeability of the membrane
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Ionotropic transduction - response
Rapid 10-50ms
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Ionotropic transduction - latency
Short latency action
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Ionotropic transduction - mechanism
Binding site and channel combined
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Ionotropic transduction - location
Postsynaptic in general
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Metabotropic transduction - response
Slow
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Metabotropic transduction - response
Slow
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Metabotropic transduction - latency
Longer
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Metabotropic transduction - mechanism
Binding site not associated with channel G-protein or 2nd messenger involvement
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Metabotropic transduction - location
Pre or postsynaptic
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What are commonly metabotropic systems
Some taste receptors Photoreceptors
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Which mechanism of transduction are most senses
Ionotropic
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2 roles of sensory receptor
Transduction Encoding information about the stimulus
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Labelled lines principle
Even though all receptors use action potentials to encode stimuli the physical destination of the sensory axons deals with each different type of sensory receptor
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Sensory receptor function- the insect bristle (sensillum)
Hollow shaft protrudes through exoskeleton and is attached to the end of a dendrite (nerve cell), which is supported by sheath and socket cells Move the bristle and the distal tip of the dendrite is stretched and deformed Deformation opens stretch-activated channels to allow cations (e.g. Na+ or K +) to move through the cell membrane generating a receptor potential across the dendrite’s plasmalemma If a threshold for membrane depolarisation is reached then an action potential is propagated
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Insect bristle (sensillum)
Small bristle movement does not cause enough depolarisation to reach a threshold – bristle movement is not detected More displacement cross the threshold and generates a train of action potentials Further deformation increases the frequency of the action potentials Transduction illustrated by the resting potential triggering an action potential Encoding illustrated by the frequency of action potentials
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Rods structure
Lamellae form discs detached from the plasmalemma
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Cones structure
Lamellae are continuous with the plasmalemma
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In the dark - vertebrate eye
In the dark Na+ channels are relatively open and there is a flow of ‘dark’ current across a relatively depolarised (-30mV) cell membrane in the outer part of the cell
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Light stimulation
Metabotropic transduction Rods contain rhodopsin- activated by light Activated rhodopsin stimulates transducin, a G-protein to activate a phosodiesterase enzyme Enzyme decreases cyclic guanosjne monophosphate (cGMP) concentration in the receptor cytoplasm Decrease in cGMP closes cyclic-nucleotide-gated channels for Na+ and reduces its influx into the cytoplasm
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Response to light
Hyperpolarisation Causes ion channels to close reducing the dark current
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Neuron
long, thin cell surrounded with plasmalemma and Schwann Cells (neurolemmocyte) and a Myelin Sheath
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Resting membrane potential
Sodium (Na+) and potassium (K+) ions continually diffuse across the plasmalemma Cl- ions and large negatively charged molecules cannot cross the plasmalemma Na+ and K+ concentrations on each side of the plasmalemma remain constant because sodium-potassium ATPase actively moves 3x Na+ out and 2x K+ in to the cytoplasm Produces a resting potential of –70mV
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Depolarisation
A neuron transmits a signal as an action potential in response to a stimulus The stimulus must of a sufficient size to cross a threshold that triggers the localised movement of ions across the plasmalemma The threshold stimulus increases permeability to Na+ ions which all rush into the cytoplasm and neutralises the resting potential, i.e. –70 mV → 0 mV = depolarisation The influx of Na+ ions temporarily confer a positive charge to the cytoplasm
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Repolarisation
Almost immediately voltage-gated Na+ channels close and voltage-gated K+ channels open and K+ ions leave the cytoplasm to build up a positive change again This sequence of events triggers the same molecular changes in adjacent areas of the plasmalemma and the action potential moves along the axon
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Hyperpolarisation - refractory period
After the action potential has moved on the membrane becomes hyperpolarised (more than –70mV) because of uncontrolled movement of K+ Sodium-potassium ATPase restores the resting potential During hyperpolarisation the membrane is insensitive to triggering another action potential This whole process takes ~ 3 milliseconds
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Total length of action potential
3 ms
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All or nothing
exceeding the stimulus threshold does not increase the size of the action potential
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Speed of transmission
increased by increasing axon diameter - most vertebrate axons < 10μm Some fish and amphibians have unmyelinated axons ~ 50μm (involved in rapid escapes) Myelination increases transmission by Saltatory conduction from node of Ranviers
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Squid axons
1 mm wide and conduct an action potential at 36 m per second
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Cell bodies cluster
nuclei” in CNS and “ganglia” in PNS
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Types of synapses
Axosecretory Axoaxonic Axodendritic Axoextracellular Axosomatic Axosynaptic
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Axosectretory
Axon terminal secretes directly into bloodstream
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Electrical synapses
between two neurons Positively charged ions from the presynaptic end bulb directly depolarise the adjacent neuron
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Chemical synapse
between neuron and a range of cell types Requires chemical agent called a neurotransmitter (e.g. acetylcholine or norepinephrine) to diffuse across the synaptic cleft
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Chemical synapse mechanism
An arriving action potential stimulates the free diffusion of calcium ions into the presynaptic terminal Increased calcium ion concentration stimulates the merging of vesicles containing neurotransmitter molecules with the plasmalemma The neurotransmitters are released into, and diffuse across, the synaptic cleft Binding of the neurotransmitter molecules to the post-synaptic plasmalemma triggers depolarisation of the post-synaptic cell to generate an action potential Neurotransmitter is quickly de-activated by the post-synaptic cell Failure to deactivate would lead to continual stimulation of the cell
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Cnidarians neural networks
Interconnected neurons that form complex 2D nerve nets
97
Polyp neural networks
Entire nervous system is comprised of 2 nets
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Invertebrate neural networks
One net lies at the base of the epidermis and the other at the base of the gastrodermis Neurons bridge the mesoglea Nerve impulses can move in any direction though the nets Diffusion conduction means that a stimulus at one point on the net radiates outwards like ripples on a pond No central control for coordinated responses
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Neural networks in swimming medusa
In swimming medusa, first indications of coordinated control are seen as nerve rings and ganglia are found around the margin of the bell Associated with sensory organs – e.g. ocelli, and the swimming musculature Ganglia are concentrations of neurons that serve as simple integration centres. Each ganglion is associated with a sensory organ and can generate motor output Greatest output from ganglia controls muscular activity Contraction of the musculature must be simultaneous so neurons in the nerve ring couple with muscle cells electrically with gap junctions
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Nematoda
Intraepithelial nervous system Brain is collar-like and circumpharyngeal nerve ring 2 longitudinal nerve cords
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Annelids
Anterior brain consisting of 2 dorsal suprapharyngeal ganglia 2 ventral longitudinal nerve cords and paired segmental ganglia
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Insecta
Dorsal supra-oesophageal ganglia (brain`0 in the head with 2 connectives that circle the gut linking to 2 ventral longitudinal nerve cords Paired segmental ganglia with sensory and motor neurons Brain has 3 parts = protocerebrum, deutocerebrum and triocerebrum
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Arachnida
Highly cephalised central nervous system All segmental ganglia have coalesced in the supra-oesophageal and sub-oesophageal ganglia 2 abdominal nerves extend longitudinally along the body
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Gastropoda
Brain and 2 large, longitudinal nerve cords Brain-ring of four anterior ganglia wrapped around the anterior alimentary tract Trend towards Cephalisation and fusion of the ganglia into a brain-liege structure Twisted configuration
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Cephalopoda
CNS is highly cephalised, strongly concentrated and bilaterally symmetrical, enclosed in a cartilaginous cranium Supra-oesophageal part associated with sensory function Sub-oesophageal part associated with motor function Each appendage has a brachial nerve
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Squid axons
Squid have giant axons – 1 mm in diameter, which allow for rapid transmission of action potentials Diameter of axons depend on length – short ones are narrow – allows for coordinated motor responses because action potentials all arrive at the same time
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Echinodermata
Radial symmetry- - posses nerve ring around the gut and 5 radial nerves (1 per ambulacra) 2 connected neural nets - sensory ectoneural = epidermis Motor hyponeural = coelomic lining
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Evolution of invertebrate nervous system
Neural nets increasingly integrated with a localised central nervous system with different sensory and motor networks Segmented ganglia Increasing coalescence of nerve tissue associated with the head and often ringing the anterior gut linked to ventral longitudinal nerve cords Nerve rings that coordinate responses to stimuli Generalised nerve nets
109
Chordata - amphioxus
Rudimentary hollow brain Dorsal hollow nerve cord almost to the end of the tail Segmental sensory nerves Anterior neuropore that contain cilia that maintain a flow of water over and into the pore Brain no longer wrapped around the anterior part of the alimentary tract
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Sensory (afferent) nerves
Visceral Somatic
111
Motor (efferent) nerves
Somatic nervous system Autonomic - sympathetic, parasympathetic and enteric
112
Parasympathetic nervous system
During relaxation Nerves arise from the brain and sacral region of spinal cord Long efferent nerve fibres that synapse with ganglia in vicinity of organs and short efferent neurons that extend from the ganglia to the organs Stimulates salivary gland secretions, contracts pupils and relaxes sphincter muscles
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Sympathetic nervous system
division functions during “fight or flight” response Nerve fibres originate from the thoracic and lumbar regions of spinal cord to ganglia near the spine and long efferent neurons that extend to the organs Inhibits salivary gland secretions, dilates pupils and tightens sphincter muscles
114
Enteric nervous system
Networks of neurons in the pancreas, gall bladder and digestive tract that control gut function Normally regulated by the sympathetic and parasympathetic systems
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Development of nervous tissue in vertebrates
Nervous tissue is derived from ectoderm (outer cell layers) All vertebrates have a mesodermal notochord during development – forms basis for vertebral column Associated with a dorsal neural tube created by folding of ectoderm tissues
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3 layers enclosing the CNS
Dura matter – tough fibrous Arachoid – delicate Pia mater – contains small blood vessels that nourish the tissue
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Spinal cord
Central neural canal filled with cerebrospinal fluid Composed of grey and white matter Spinal nerves – number depends on degree of segmentation
118
Grey matter
Cell bodies and dendrites (associated with reflex connections)
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Where do spinal nerves extend from
Grey matter
120
White matter
Axons surrounded by myelin sheaths
121
Lamprey - fish
No myelinated axons (no white matter) Shape helps facilitate diffusion of nutrients and oxygen In spinal cord
122
Comparative morphology of spinal column
The distribution of white and grey matter differs between the various vertebrate groups. The lamprey, being a very primitive fish, lacks any white matter. Sharks have dorsal and ventral horns of grey matter surrounded by white matter and a sheath. Amphibians have ventral and dorsal horns of grey matter – the latter extend to the edge of the spinal cord – within white matter. Reptiles have grey matter surrounded by white matter but in the spinal cords of mammals and birds the dorsal grey matter extends to the edge of the spinal cord.
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Formation of the brain
During early development anterior neural tube expands by accumulation of cerebrospinal fluid to form different parts that become folded and lie on top of each other Brains have three main parts – forebrain (telencephalon and diencephalon), midbrain (mesencephalon) and hindbrain (rhombencephalon) each with different roles
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Telencephalon
Forebrain Cerebrum – two hemispheres and related to sensory and motor integration Expanded tissue and increased complexity reflects importance of the brain region Cerebral cortex – primary sensory and motor areas Other areas deal with processing visual or auditory perception
125
Diencephalon
Forebrain Thalamus – relays sensory information to higher brain centres Hypothalamus – controls many bodily functions – body temperature, sexual drive, metabolism, hunger and thirst Pineal gland – controls bodily rhythms Fish – processes sensory information
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Cranial nerves
Fish & amphibians – 10 pairs; Reptiles, birds and mammals – 12 pairs Sensory-only and mixed nerves – e.g. vagus has sensory neurons leading to the brain and motor neurons leading to the heart and visceral organs
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Midbrain
Centre for coordinating responses to visual stimuli Evolution of mid brain – also coordinates touch and auditory processing
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Hindbrain
Medulla oblongata connects brain to spinal column – reflex centre for breathing, swallowing, cardiovascular function and gastric secretion Cerebellum – outgrowth of medulla oblongata and coordinates motor activity (posture, movement, spatial orientation) Pons connects forebrain cerebrum to cerebellum and is important in the regulation of breathing
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Medulla oblongata
Reflex centre for breathing, swallowing, cardiovascular function and gastric secretion
130
Cerebellum
Coordinates motor activity (posture, movement, spatial orientation)
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Pons
Regulation of breathing
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Pineal gland
Controls bodily rhythms Secretes melatonin
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Hypothalamus
Controls bodily functions- body temperature, sexual drive, metabolism, hunger and thirst
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Thalamus
Relays sensory information to higher brain centres
135
Number of cranial nerves in fish and amphibians
10 pairs
136
Number of cranial nerves in birds and mammals
12 pairs
137
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Somatosensory systems
Proprioception Touch Temperature Pain
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Which senses detect particulate matter not energy
Olfaction Gustation
140
Olfactory system
Olfactory epithelium Olfactory nerves - olfactory receptors Olfactory bulbs - glomeruli and mitral cells Rest of CNS Accessory olfactory bulb
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What is found in the nasal cavity
Olfactory epithelia Olfactory nerves and receptors
142
How does olfaction aid in survival
Finding food Finding mates Mother and young bond Detecting predators
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Chain of olfaction
Air passes through the nares into the nasal cavity Pushed with turbulence over the olfactory epithelium Particles bind to olfactory receptors Transducer into signals via olfactory nerve to olfactory bulb Glomeruli activated Information passed via olfactory tract to a range of brain areas Decision are made - motor outputs
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What is an odour
A mixture of molecules that is different from its surroundings and that trigger a sensation in the animal detecting it Defined by the nature and concentration of the odorants that are present in it Form a plume in air or carried by water
145
Olfactory neurons
Cilia
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Mucous
Protects from toxins/oathogens Helps some odorants bind Contains enzymes which degrade odours once bound
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Which senses are present at birth in cats and dogs
Warmth/touch Olfaction
148
Importance of glomerular mapping
Glomeruli can be in or off so this allows for a vast array of odour maps 2^N N - number of odour receptors Vast number of odours can be distinguished
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Learning and activation of olfactory bulb
Odour + reward = increased activation Odour + danger = increased activation
150
2 olfactory pathways
One associated with innate odour properties One associated with learning
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Chief enervation
Olfactory cortex Piniform cortex Parts of amygdala
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Mitral cells
May help in encoding information about concentration
153
Piriform cortex
Involved in: Categorising odours with hedonic value Memorising odours Perceiving similarity Integrating olfactory information with information from other sensory systems
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Role of hippocampus in olfaction
Memory
155
Sniffing
Direct molecules to olfactory epithelium Better odour detection
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What is a sniff
Nostril movement Respiratory muscles
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Nostrils and sniffing
Nostrils sample separately Lateralisation of sniffing Ipsilateral information from nostril to hemisphere Right hemisphere deals with arousing stimuli Right nostril bias for arousing odours Neutral stimuli - first right nostril sniff- novelty and then shift to left nostril sniff
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Tracking
Bilateral sampling for odour localisation
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How is the majority of odours sensed then processed
Ipsilateral
160
Advantage of sniffing
Back flow of air creates turbulence Does not disrupt odour
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Pressure sensitive receptors
Ruffini’s endings Krause’s end bulbs Pacinian corpuscle
163
Fine touch receptors
Meissner’s corpuscle Merkel disks Root hair plexus
164
Temperature and pain receptors
Free nerve endings
165
Warmth receptors
Ruffini’s endings
166
Cold receptors
Krause’s end bulbs
167
Where is the cell body in the somatosensory system
Dorsal root ganglion of a spinal nerve Or Ganglia of the trigeminal or cranial nerves
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Where do the secondary somatosensory neurons terminate
Thalamus Or Cerebellum
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Where do nociceptors or thermoreceptors decussate
Spinal cord
170
Where do mechanoreceptors or proprioceptors decussate
Medulla
171
Somatosensory cortex
Post central gyrus of the parietal lobe Forms a sensory homunculus in the case of touch
172
Where are the tertiary somatosensory cell bodies
Thalamus For posture- in the cerebellum
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Nociception
Detection of noxious stimuli by nociceptors
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Pain
Unpleasant emotional and sensory experience Product of processing in the brain
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International association for the study of pain
An unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage
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Nociceptors
Free, branching, unmyelinated nerve endings Sub population of peripheral nerve fibres In skin, joints, viscera, bone and muscle Detect thermal, mechanical or chemical stimuli suggestive of injury - ongoing inflammation
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Different pain triggers
Thermal Mechanical eg cut Chemical Mechanical stress Chemical inflammation Mechanical distension Traction Chemical irritants Strenuous mechanical exertion Chemical modalities
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Biology of pain
Damaged tissue releases and produces factors activate nerve endings eg potassium, histamine and serotonin or bradykinin, prostaglandins or leukotrienes
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What does noxious stimulus stimulate
Transducer channels, initiates receptor potentials and induces an action potential
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2 classes of nociceptors
A-delta C fibres
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A-delta
Medium diameter Myelinated Convey an acute, well-localised fast pain
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C fibres
Small diameter Unmyelinated Convey a poorly localised slow pain
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Regions of brain associated with pain processing
Thalamus Amygdala Hypothalamus Periaqueductal grey Basal ganglia Brain stem reticular formation
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Pain modulation
Inputs from the frontal cortex and hypothalamus Outflow is through the midbrain and medulla to the dorsal horn of the spinal cord Inhibits pain-transmission cells, thereby reducing the intensity of perceived pain
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Nociceptors withdrawal reflex
Action potential in sensory neuron sends an excitatory postsynaptic potential (EPSP) to a somatic motor neuron in the spinal cord —> activates multiple reflex pathways—> stimulate the flexor muscle of the ipsilateral limb causing withdrawal Also activate an inhibitory postsynaptic potential to inhibit extensors of ipsilateral limb Also activates an interneurons that decussates and crosses the spinal cord midline —> stimulates a contralateral extensor muscle —> crossed-extension reflex (postural support)
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Opioid receptors
Regulate the neurotransmission of pain signals Activation = reduction in neurotransmitter release and cell hyperpolarisation, reducing cell excitability and thus action potential generation
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Endogenous opioids
Can modulate pain physiologically
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Exogenous opioids
Eg morphine Act on receptors Analgesia
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Where do the nociceptive fibres run in the spinal cord
Centre