Sepsis

Question 1

Define sepsis

Answer 1

Life-threatening organ dysfunction due to a dysregulated host response to infection

Question 2

What makes up a quick sofa score in veterinary

Answer 2

Mentation
Blood pressure
RR

Award one point

•if abnormal mentation/dull/obtunded/stuporous
• RR >22/min
• SBP <100mmhg

Question 3

Which cytokines stimulate the HPA axis to increase CRH and ACTH secretion

Answer 3

IL-1, IL-6, TNF alpha

Question 5

Sepsis in shock what type and why?

Answer 5

TypeB1 -underlying dz

Pathophysiology:

•Stimulation of skeletal muscle Na/K ATPase by catecholamines
•mitochondrial dysfunction including direct cytochrome inhibition
•increased hepatic lactate production
•reduced hepatic lactate extraction
•Impaired tissue oxygen extraction
•capillary shunting
•enhanced NO production
•altered neurohormonal control of endothelial smooth muscle
•reduced RBC flexibility
•increased leukocyte activation
•pyruvate dehydrogenase inhibition

Question 6

Name drugs or toxins associated with type B2 hyperlactatemia

Answer 6

Acetaminophen
Activated charcoal
Bicarb
Steroids
Ethylene glycol
Cyanide
Lactulose
Methanol
Sorbitol
Xylitol
Salicylates
Propylene glycol