Sepsis Lecture

Question 1

metastatic lesions are a sign of what

Answer 1

septicemia

Question 2

fever, rash, hypotension are signs of

Answer 2

shock

Question 3

drug used against penicillin resistant staph

Answer 3

vancomycin

Question 4

drug used against methicillin resistant staph

Answer 4

vancomycin

Question 5

drug used against vancomycin resistant staph

Answer 5

oxolidinones (linezolid)

Question 6

strep species involved in the normal oral microbiota

Answer 6

Streptococcus mutans

Question 7

what protein involved w/ S. pyogenes is responsible for sequelae of RF and glomerulonephritis b/c it binds factor H and disrupts complement

Answer 7

M protein

Question 8

what provides evidence of a previous Strep infection

Answer 8

high antistreptolysin O titers

Question 9

hemolysin of strep that lyses blood anaerobically

Answer 9

Streptolysin O

Question 10

strep exotoxins cause what through cytokine storm

Answer 10

toxic shock like syndrome (septic shock)

Question 11

sx’s include confluent rash and strawberry tongue

Answer 11

scarlet fever

Question 12

drug used to treat GAS

Answer 12

penicillin

Question 13

drug used to treat syphillis

Answer 13

penicillin G

Question 14

drug/s used to treat Group D strep

Answer 14

syngery b/t ampicillin and aminoglycoside

Question 15

fever, altered mental status, hypotensive, petechial rash

Answer 15

Neisseria meningitis

Question 16

gram - diplococci (kidney bean shape); oxidase +

Answer 16

Neisseria

Question 17

what type of N. meningitis resembles K1 capsule of E. coli

Answer 17

type B

Question 18

endotoxin (lipid A-LOS), carbohydrate capsule, pili, exotoxin cleaving IgA are virulence factors of

Answer 18

N. meningitis

Question 19

what interaction activates clotting factors

Answer 19

lipid A binding to TLR4

Question 20

usually starts as sore throat and is found in closed populations

Answer 20

N. meningitis

Question 21

2 outcomes of meningococcemia:

Answer 21

gradual-sepsis
fulminating- clotting factors increased

Question 22

petechiae and multisystem organ failure are signs of this

Answer 22

Disseminated intravascular coagulation

Question 23

leads to adrenal hemorrhage and death

Answer 23

Waterhos-Friderichsen syndrome

Question 24

to treat N. meningitis

Answer 24

Ceftriaxone

Question 25

gram - rods that can cause septicemia or sepsis that are found in intestinal tract

Answer 25

Enterobacteriaceae

Question 26

high fever (>102), recent travel history to Mexico, sore throat, HA, diarrhea, abdominal tenderness (small pink papule rash); elevated liver enzymes; lactose non-fermenting gram - rod

Answer 26

Salmonella

Question 27

2 types of Salmonella enterica

Answer 27

serotype Typhi serotype Choleraesuis

Question 28

S. enterica serotype Typhi causes:

Answer 28

Typhoid fever

Question 29

S. enterica serotype Choleraesuis causes:

Answer 29

Septicemia

Question 30

virulence factor for Salmonella Typhi

Answer 30

capsule Vi Ag

Question 31

fever, GI symptoms, rose spots, elevated liver enzymes

Answer 31

typhoid fever

Question 32

abrupt onset of fever w/ rapid rise, often no GI sx's, metastatic infections

Answer 32

septicemia from S. choleraesius

Question 33

source of typhoid fever pathogen

Answer 33

contaminated food or water (fecal contamination)

Question 34

treatment for S. Typhi or Cholerasuis

Answer 34

Ceftriaxone

Question 35

treatment for Salmonella in carrier state

Answer 35

Amoxicillin or quinolones

Question 36

vaccine for typhoid fever targets what

Answer 36

Vi Ag capsule

Question 37

flu-like sx's, LAD of axilla, recent travel history from Four Corners of New Mexico; prairie dogs, bipolar staining

Answer 37

Yersinia pestis (bubonic plague)

Question 38

gram - facultative intracellular pathogen; F1 capsule; bipolar staining

Answer 38

Y. pestis

Question 39

reservoir for Y. pestis

Answer 39

rodents

Question 40

vector for Y. pestis

Answer 40

flea

Question 41

To treat Bubonic plague

Answer 41

streptomycin, kanamycin doxy

Question 42

gram - coccobacillus (think the radishes in sketchy); has lipid capsule

Answer 42

F. tularensis

Question 43

reservoirs for tularemia

Answer 43

rabbits

Question 44

vectors for F. tularemia

Answer 44

ticks and deerflies

Question 45

causes ulcer at site of infection; LAD

Answer 45

Tularemia

Question 46

to treat F. tularensis

Answer 46

aminoglycosides

Question 47

high fever, night sweats, travel history to Honduras, ate goat cheese, undulating fever (gram - coccobacillary)

Answer 47

Brucellosis

Question 48

2 oxidase + bacteria

Answer 48

Neisseria and Brucella

Question 49

reservoir for brucella

Answer 49

farm animals

Question 50

to treat Brucellosis

Answer 50

doxycycline and rifampin (think the wheel and old skinny man with rifle in sketchy)

Question 51

rigors, high fever, sob, dry cough, malaise, lung infiltrates, gram + rods

Answer 51

Bacillus anthracis---> anthrax

Question 52

peptide capsule of B. anthracis is composed of what

Answer 52

D-Glutamate

Question 53

ESCHAR; more susceptible if you work with animal hides

Answer 53

Anthrax

Question 54

anthrax toxin composed of what:

Answer 54

3 components PA, EF, LF

Question 55

test used to detect spores in B. anthracis or C. difficile

Answer 55

PCR

Question 56

treatment of Anthrax

Answer 56

Cipro and Doxy (think sketchy pic)