Sex hormones & Gonadotropins Flashcards Preview

Pharm Exam 6 > Sex hormones & Gonadotropins > Flashcards

Flashcards in Sex hormones & Gonadotropins Deck (25):
0

Gonadorelin

GnRH agonist, short acting, for infertility.
Not in the US

1

Leuprolide

GnRH agonist- long acting, initial inc release then suppresses LF/FSH.
Tx: shut down HPG axis- infertility, prostate/breast ca, delay precocious puberty, endometriosis, PCOS, uterine leiomyomas
Adv: menopausal sx, testes atrophy, ovarian cyst
PROSTATE CA: use w/ antiandrogens at first!!!!

2

Nafarelin

GnRH agonist- long acting, initial inc release then suppresses LF/FSH.
Tx: shut down HPG axis- infertility, prostate/breast ca, delay precocious puberty, endometriosis, PCOS, uterine leiomyomas
Adv: menopausal sx, testes atrophy, ovarian cyst
PROSTATE CA: use w/ antiandrogens at first!!!!

3

Goserelin

GnRH agonist- long acting, initial inc release then suppresses LF/FSH.
Tx: shut down HPG axis- infertility, prostate/breast ca, delay precocious puberty, endometriosis, PCOS, uterine leiomyomas
Adv: menopausal sx, testes atrophy, ovarian cyst
PROSTATE CA: use w/ antiandrogens at first!!!!

4

Cetrorelix

GnRH antagonist- supp release of LH (low dose), FSH (high dose)
4-5d tx, no initial Gn surge
Tx: endometriosis, ART

5

Ganirelix

GnRH antagonist- supp release of LH (low dose), FSH (high dose)
4-5d tx, no initial Gn surge
Tx: endometriosis, ART

6

Urofollitropin

purified FSH
stim ovaries and estrogen, drives spermatogenesis

7

Follitropin-a
Follitropin-b

rFSH
Expensive, no urine contaminants
stim ovaries and estrogen, drives spermatogenesis

8

hMG

Human menopausal gonadotropins- LH+FSH but used as FSH
stim ovaries and estrogen, drives spermatogenesis

9

Menotropins

LH+FSH but used as FSH
stim ovaries and estrogen, drives spermatogenesis

10

hCG

Human chorionic gonadotropins, similar structure to LH, longet T1/2
IM admin
Sg dose to induce ovulaiton, inc Testosterone in males (up to a yr)

11

Choriogonadotropin-a

recombinant hCG- acts as LH
SC admin
Sg dose to induce ovulaiton, inc Testosterone in males (up to a yr)

12

Lutropin

Recombinant LH
Only for combo c follitropin-a (rFSH)
Sg dose to induce ovulaiton, inc Testosterone in males (up to a yr)

13

Estradiol

(Estrace, Estraderm)
Estrogen- endogenous
not orally active -cream/patch

14

Ethinyl estradiol
Mestranol

Synthetic estrogen
Combo oral contraceptives

15

Premarin

Conjugated estrogen - equine
HRT

16

Cenestin

Conjugated estrogen - soy
HRT

17

Diethylstilbestrol (DES)

Non-steroid - estrogenic activity
CI in pregnancy

18

Tamoxifen

Estrogen agonist in uterus/bone, antagonist in breast
DOC: premenopausal estrogen dependent breast CA (prevent bone loss), no hot flash relief
Adv: risk of uterine CA, dec HDL, hot flashes, n/v
CI: thromboembolism, breast feeding

19

Toremifene (Fareston)

Estrogen agonist in uterus/bone, antagonist in breast (tamoxifen like)
For high HDL

20

Raloxifene (Evista)

Estrogen agonist in bone/liver, antagonist in breast/uterus
To prevent postmeno osteoporosis (inc bone density)
Adv: hot flashes, DVT, leg cramps

21

Clomiphene (Clomid)

Estrogen antagonist in hypothalamus (inc LH/FSH, no neg feedback)
Agonist elsewhere
DOC infertility (women c intact HPG)
Adv: mltp preg, hot flashes, HA, constipation, allergic, hair loss, enlarge ovaries

22

Fulvestrant (Faslodex)

Pure estrogen receptor agonist
For tamoxifen resistant tumors
Adv: hot flashes, GI, HA, back pain, pharyngitis

23

Anastrozole (Arimidex)
Letrozole (Femara)

Non-steroidal comp inhibitor of aromatase (only estrogen synth inhibit)
DOC: postmeno breast CA. 2nd line: postmeno breast CA that progressed w/ tamoxifen.
Adv: menopausal sx, bone fractures, jnt pain
CI: premenopausal, pregancy

24

Exemestane (Aromasin)

Irreversible inhibitor of aromatase (only estrogen synth inhibit)
DOC: postmeno breast CA. 2nd line: postmeno breast CA that progressed w/ tamoxifen.
Adv: menopausal sx, bone fractures, jnt pain
CI: premenopausal, pregancy