Sexual Development Flashcards
(25 cards)
Genetic sex
x and y chromosomes
phenotypic sex
genitals form between 8-12 weeks
final maturation and sex characteristics continue through _____
puberty
Gonads are the same until
6 weeks of gestation
2 duct systems
wolfian
mullerian
wolfian duct leads to
testes
mullarian duct leads to
ovaries
which chromosome has the sex determining region (SRY)
Y chromosome
SRY produces
testes determining factor (TDF)
differentiation of gonads happens at
8-12 weeks
leydic cells
produce testosterone
Sertoli cells
eventually produce sperm
testosterone acts on wolfian ducts to develop ____
Internal genitalia (epididymis, seminal
vesicles, vas deferens
Converted to DHT to make penis, scrotum,
and prostate
Sertoli cells secrete ____
Mullerian Inhibiting substance/hormone (MIS/MIH) which cause regression of mullerian duct
Anything not conforming to
average patterns are usually
referred to as
differences of sex
development (DSD)
which set of chromosomes are sex?
23
Turner Syndrome
45 XO
only one x chromosome so has 45 and not 46
Klinefelter syndrome
47 XXY
Trisomy X - super female
47 XXX
super male
47 XYY
Congenital adrenal hyperplasia (CAH)
Increase in sex hormone production
from adrenal gland
CAH if XX
viralized genitals
Enlarged clitoris, engorged labia
which look like a scrotum
CAH if XY
viralized genitals
Often unnoticed until childhood
Concerns with CAH
changes electrolytes, blood pressure
can cause death of not managed
