Sexual Dysfunction

Question 1

flibanserin is for sexual dysfunction in women and can cause what side effect

Answer 1

fainting

Question 2

what conditions can cause erectile dysfunction

Answer 2

hypertension, atheroschlerosis, diabetes (causes neuropathies)

Question 3

what drugs classes can contribue to erectyle dysfunction

Answer 3

alcohol, antidepressants, antihypertensives (esp bb, clonidine), antipsychotics (esp 1st generation), BPH meds

Question 4

what arenatural products that can treat ED

Answer 4

yohimbe, L- argenine, panax ginseng

Question 5

1st line for treatment of ED

Answer 5

PDE5 inhibitors (sildenafil, vardenafil, tadalafil, avanafil)

Question 6

absolute contraindication PDE-5

Answer 6

nitrates due to severe hypotension

Question 7

main reason for treatment failure of pde5

Answer 7

timing of dose

Question 8

what is the other indicaion of tadalafil (cialis)

Answer 8

benign prosthetic hyperplasia and pulmonary arterial hypertension (also sildenafil)

Question 9

viagra starting dose and dose to reduce to in select conditions

Answer 9

50mg –> 25mg

Question 10

Cialis and Levitra starting dose and dose to reduce to

Answer 10

10mg –> 5mg

Question 11

Stendra starting dose and dose to reduce to

Answer 11

100mg –> 50mg

Question 12

What are the select conditions to reduce dose

Answer 12

> 65, using an alpha-blocker, using a CYP3A4 inhibitor (PACMANG), Severe liver or renal disease

Question 13

sildenafil and vardenafil timing before activity

Answer 13

take 1 hour before activity

Question 14

tadalafil timing before activity

Answer 14

30 min

Question 15

avanafil time before activity

Answer 15

15-30 min

Question 16

when to seek medical help on a pde5

Answer 16

if the erection lasts more than 4 hours, if chest pain

Question 17

warnings for pde5 inhibitors

Answer 17

vision loss (impaired color discrimination), hearing loss, hypotension, priapism

Question 18

administration of pde5

Answer 18

with or without food but sildenafil and vardenafil may have decreased efficacy with a high-fat meal

Question 19

how many doses per day for ED

Answer 19

one

Question 20

if on an alpha-blocker how do you start a PDE5 inhibitor

Answer 20

make sure stable on alpha-blocker

Question 21

what molecularly happens during an erection

Answer 21

local release of nitric oxide to increase cGMP and causes smooth muscle relaxation to permit blood flow in

Question 22

moa of a pde5 inhibitor

Answer 22

block pde5 from degrading cGMP

Question 23

MOA of alprostadil

Answer 23

it is a prostoglandin E1, a vasodilator that allows blood to flow into the arteries. Either injected into the penis or a pellet is inserted through the urethra

Question 24

flibanserin and bremelanotide moa and indication

Answer 24

agonist activitis at 5-HTIA and used in premenopausal females only

Question 25

contraindication filbanserin

Answer 25

contraindicated with alcohol (REMS) and in combination with CYP3A4 inhibitors

Question 26

bremelanotide comes in what form and is contraindicated in what

Answer 26

injection, contraindicated in cardiovascular disease

Question 27

revatio is what

Answer 27

sildenifil for PAH

Question 28

adcirca is what

Answer 28

tadalafil for PAH

Question 29

cialis is what

Answer 29

tadalafil

Question 30

viagra is what

Answer 30

sildinefil

Question 31

levitra

Answer 31

verdenafil

Question 32

stendra

Answer 32

avanafil