Oncology 1 part 2 Flashcards
(49 cards)
low white blood cells cause
leukopenia, increased infection risk
Low rbcs cause
anemia, with weakness and fatigue
low platelets cause
thrombocytopenia, with high risk of severe/uncontrolled bleeding
lowest point that wbcs and platelets reach is called what and occurs hwow long after chemo
nadir, usually occurs 1-2 weeks after chemo with the rbc nadir being much longer at 120 days (4 months)
how long does it take for both rbc an dplatelets to recover
3-4 weeks
What do CSF stimulate
WBC’s - pegfilgastrim and filgastrom
what do EPO stimulate
RBC, but rarely used because decrease surival (darbapoetin and epopoetin)
platelet cutoff for transfusion
less than 10,000
side effect of csf and monitoring
achy bones and joints, fever, myalgias, rash
report any sign of enlarged slpeeen, document when pegfilgastram was given
fever cutoff for neutropenia
38.3 (101)
celcius to farenheit equation
F = C * 1.8 +32
oral anti pseudomonal prophylaxis regimen
ciprofloxacin or levofloxacin
plus
augmentin or clindamycin (if allergic to penicillin)
IV anti pseudomonal regimen
cefepime
or
ceftazidime
or
carbopenem (except ertapenem
or
zozyn
what are all the pseudomonas covering antibiotics
Cefepime (4th gen), ceftazidime (3rd gen)
Carbopenems (except ertapenem)
Quinolones (levofloxacin, ciprofloxacin)
Aminoglycosides (gentamicin, tobramicin, amikacin)
Zozyn
Which factors increase risk of chemo induced nausea and vomiting
female gender
<50 years age
dehydration
hx of motion sickness and hx of nausea and vomiting
acute nausea onset and tx
within 24 hours of chemi, 5ht3 receptor antagonists preferred
delayed onset tx
greater than 24 hours after chemo, nk1-RA, corticosteroids, palosetron (h5t3), and olanzapine(other) preferred
anticipatory nausea tx
benzo the evening prior to chemo preferred
what regimen to give with cisplatin
highly emetogenic - give 3 or 4 drugs from each category
5ht3a main side effects
headaches and constipation
main side effects of dopamine receptor antagonists (such as prochlorperazine, promethazime, and metoclopramide)
sedation, EPS
droperidol has what risk
QT prolongation
emend
apirepitant or fosaprepitant
zofran
ondanetron
