Oncology 1 part 1

Question 1

Draw Chemoman

Answer 1

see pg 813

Question 2

Bleomycin lifetime dose

Answer 2

400 units due to pulmonary toxicity

Question 3

Doxorubicin Lifetime Dose

Answer 3

450-550 mg/m2 due to cardiotoxicity

Question 4

Cisplatin lifetime dose

Answer 4

Dose per cycle not to exceed 100 mg/m2 due to nephrotoxicity

Question 5

Vincristine max dose

Answer 5

Single dose capped at 2mg due to neuropathy

Question 6

BSA (m2)=

Answer 6

square root of ht (cm) * wt (kg) / 3600

Question 7

what is given to prevent cardiotoxic effect from doxorubicin

Answer 7

dexrazoxane

Question 8

M in chemo man

Answer 8

methotrexate –> causes mucositis (so does flurouracil)

Question 9

which chemo drugs do not cause myelosupression

Answer 9

asparagomase, bleomycin, vincristine

Question 10

What can be given with irnotecan for early onset diarrhea

Answer 10

atropine

Question 11

what should be given with cisplatin to reduce the risk of nephrotoxicity

Answer 11

amifostine (ethyol), also hydration

Question 12

which drugs can increase risk of cloitting

Answer 12

Aromatase inhibitors (anastrozole, letrozome) and SERMS (tamoxifen and raloxifine)

Question 13

What is given with methotrexate to decrease myelosupression and mucositis in high doses therapy

Answer 13

leucovorin (folic acid also given)

Question 14

What is given as an antidote to methotrexate due to acite renal failure

Answer 14

glucarpidase

Question 15

N stands for

Answer 15

Nitrosoureas (Lomustine, Carmustine) - CNS toxicity

Question 16

C stands for

Answer 16

platinum based (i.e. cisplatin, carboplatin) –> nephrotoxicity/ototoxicity

Question 17

ethyol

Answer 17

amiofistine, the drug that is given prophylactically to reduce neporptoxicity risk with cisplatin

Question 18

B stands for

Answer 18

Bleomycin, Busolfan, Carmustine, Lomustine —> pulmonary fibrosis

Question 19

D stands for

Answer 19

Doxarubicin and other anthracyclines –> Cardiotoxic

Question 20

IP

Answer 20

Ifosfamide and cyclophosphammide –> hemmorhagic cystitis (bladdes oozes blood)

Question 21

What is given with Ifosfamide and higher doses of cyclophosphamide to prevent hemorrhagic cystitis

Answer 21

Mesna (Mesnex) and fluids

Question 23

What does VT stand for

Answer 23

Vinca Alkaloids (Vincristine, Vinblastine & Vinorelbine) and taxanes (paclitaxel, docetacel)

Question 24

What does BMS stand for

Answer 24

Bone marrow supression - ALL except vincristine, bleomycin, monocolonial antibodies (because they are targeted), and TKI’s

Question 25

which chemo drug is known to cause bad diarrhea

Answer 25

irinotecan (i run to the can)

also

capecitabine, flurouracil, methotrexate

Question 26

ANC = what equation

Neutropenia vs severe neutromenia

Answer 26

WBC * (seg% + band%)/100

Neutropenia = ANC less than 1000 cells/mm3

Severe neutropenia = ANC less than 500 cells/mm3

Question 27

neupogen

Answer 27

filgrastim

Question 28

neulasta

Answer 28

pegfilgrastim