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CSIM 2017 > Sexually Transmitted Diseases > Flashcards

Sexually Transmitted Diseases Flashcards

1
Q

Which bacteria causes Chlamydia? State the serotypes that give clinical presentations of Chlamydia.

A

Chlamydia Trachomatis, serotypes D - K

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2
Q

What is the percentage of men and women who have asymptomatic Chlamydia?

A

50% men and 80% women

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3
Q

Which type of drug is Chlamydia not susceptible to?

A

beta-lactam antibiotics

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4
Q

Is the parasite causing Chlamydia enveloped or non-enveloped?

A

Enveloped

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5
Q

Treatment for Chlamydia

A

single dose of 1g of Azithromycin or Doxycycline 100mg twice daily for 7 days

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6
Q

Is the cell envelope of Chlamydia bacteria gram negative or gram positive?

A

Gram negative

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7
Q

What bacteria causes Gonorrhoea?

A

Neisseria Gonorrhoea

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8
Q

Describe the bacteria that causes Gonorrhoea.

A

Gram negative, aerobic cocci (diplococci)

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9
Q

Gonorrhoea is often co-infected with which 3 other conditions?

A

HIV, Chlamydia and genital warts

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10
Q

Percentage of men and women who are asymptomatic with Gonorrhoea

A

50% women

5% men

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11
Q

Treatment of uncomplicated Gonorrhoea

A

Ceftriaxone and azithromycin

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12
Q

What are the clinical manifestations of Gonorrhoea in males?

A 
Gonococcal Urethritis (>80%) mucopurulent
Dysuria (>50%) - pain in micturation
Rectal infection (usually asymptomatic) can cause constipation, painful defecation and discharge
Pharyngeal infection (usually asymptomatic)
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13
Q

What are the clinical manifestations of Gonorrhoea in females?

A 
Endocervical infection (abnormal vaginal discharge)
Pelvic inflammatory disease (only if endocervical infection isn't treated)
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14
Q

Which bacteria causes Syphilis?

A

Treponema Pallidum

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15
Q

What is the shape of Treponema Pallidum?

A

Spirochete

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16
Q

What are the clinical manifestations in secondary syphilis?

A 
Maculopapular rash (raised rash) seen 6 weeks post primary lesion
Condylomata lata in anogenital area (warts that are flattened,watery and very infective)
17
Q

What are the clinical manifestations in tertiary syphilis?

A

Gummata (ulcerating lesions seen on skin and bones)
neuro-syphilis (dementia, Stroke, paralysis, blindness)
Cardiovascular syphilis (heart diseases)

18
Q

What serotypes leads to anogenital warts?

A

Serotypes of Papillomavirus 6,11,16 and 18

19
Q

What is caused by serotypes 1 and 4 of papillomavirus?

A

Plantar and facial warts

20
Q

Which serotypes causes warts on knees and fingers?

A

Serotypes of papillomavirus 2,3, and 10

21
Q

What causes Lymphogranuloma Venereum?

A

A type of Chlamydia bacteria that cause infection of mononuclear phagocytes in the lymphatic system.
(this is unlike genitourinary Chlamydia which infects squamocolumnar epithelial cells.)

22
Q

What is the most sensitive test for detecting Chlamydia or Gonococcal infections?

A

NAAT testing

23
Q

What treatment is recommended for Chlamydia?

Which is preferred if there are anorectal infections?

A

1G single dose of Azithromycin or Doxycycline 100MG BD PO for 7/7.
Doxycycline is preferred if patient has anorectal infections.

24
Q

What are the complications of Chlamydia?

A

Pelvic Inflammatory Disease (PID) –> Can lead to Fitz-Hugh-Curtis Syndrome, a complication of PID
Infertility
Ectopic Pregnancy
Neonatal conjunctivitis or Neonatal pnuemonia/RDS
Reactive arthritis

25
Q

What is the treatment for Gonorrhoea?

A

Single dose of Ceftriaxone 500MG IM + Single dose Azithromycin 1G PO

If IM is contraindicated, single dose Cefixime 400MG PO + Single dose Azithromycin 1G PO

If cephalosporins are contraindicated due to penicillin-allergy, Single dose Ciprofloxacin 500MG PO + Single dose Azithromycin 1G PO.

26
Q

What is the mainstay of syphilis diagnosis?

A

Serology

27
Q

What are the 2 types of serology testing for syphilis?

A

Non-treponemal serology and treponemal specific serology testings

28
Q

What is detected for in Non-Treponemal serology testing?

A

In non-treponemal serology testing, detection of antibodies to non-specific antigens such as Cardiolipin which is present in most patients with Syphilis

29
Q

What cream is prescribed for those with Genital Warts? What is the purpose served by the cream?

A

Imiquimod cream helps boost patient’s immune system to fight the genital warts

30
Q

How is Lymphogranuloma Venereum different from Chlamydia infection?

A

Lymphogranuloma Venereum: Chlamydia Trachomatis Serotype L1, L2 and L3 causes infection of mononuclear phagocytes in the lymphatic system.
However, in genitourinary Chlamydia, bacteria Chlamydia Trachomatis infects the squamocolumnar epithelium.

31
Q

What are buboes?

A

Buboes are grossly enlarged tender lymph nodes seen in patients with Lymphogranuloma Venereum.

CSIM 2017 (20 decks)

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