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Flashcards in Shrader & Joiner Deck (10)
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Concerning myocardial necrosis:
1) why is heart muscle at greater risk
2) which spp. are more susceptible

1) bc of its continuous activity

2) herbivores are more susceptible than carnivores


What are the sequence of changes seen with myocardial necrosis

1) coagulative necrosis (12-24hrs after insult)

2) leukocytes infiltrate by days 1-3

3) by days 10-20, healing begins (fibroblasts proliferate)

4) fibrosis begins after 6-12 weeks


How does myocardial infarction differ between dogs and cats?

in dogs, there's almost always infarction of the left ventricle & other portions of the heart

in cats, infarctions are in ALL parts of the myocardium


Describe the pathogenesis of Japanese ewe

Yew spp. contain toxic alkaloids (Taxine A & B)

they inhibit Na/Ca exchange across myocytes


primary cause associated with endocarditis?

How does it differ from endocardiosis?


endocardiosis--nodules are limited to the free margins of the valves and aren't mottled-red in color


Which cat breeds are predisposed to HCM and why?

Maine coons and ragdolls

they have a mutation in myosin binding protein C


FIP replicates where and causes what type of hypersensitivity?

in macrophages

Type III--immune complexes cause vasculitis


Describe the inheritance of duchenne muscular dystrophy (DMD); which gene is mutated?

x-linked recessive

mutation in dystrophin gene


6 important roles of dystrophin

myocyte protection
cell motility & division
myocyte contractility
vesicle and organelle movement
cell signaling
maintains cell junctions and shape


2 most used models for DMD research?

1) DMD mutant mice (don't express dystrophin)

2) golden retriever (point mutation creates a nonsense mutation)