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Flashcards in Shrader & Joiner Deck (10)
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1

Concerning myocardial necrosis:
1) why is heart muscle at greater risk
2) which spp. are more susceptible

1) bc of its continuous activity

2) herbivores are more susceptible than carnivores

2

What are the sequence of changes seen with myocardial necrosis

1) coagulative necrosis (12-24hrs after insult)

2) leukocytes infiltrate by days 1-3

3) by days 10-20, healing begins (fibroblasts proliferate)

4) fibrosis begins after 6-12 weeks

3

How does myocardial infarction differ between dogs and cats?

in dogs, there's almost always infarction of the left ventricle & other portions of the heart

in cats, infarctions are in ALL parts of the myocardium

4

Describe the pathogenesis of Japanese ewe

Yew spp. contain toxic alkaloids (Taxine A & B)

they inhibit Na/Ca exchange across myocytes

5

primary cause associated with endocarditis?

How does it differ from endocardiosis?

bacteria

endocardiosis--nodules are limited to the free margins of the valves and aren't mottled-red in color

6

Which cat breeds are predisposed to HCM and why?

Maine coons and ragdolls

they have a mutation in myosin binding protein C

7

FIP replicates where and causes what type of hypersensitivity?

in macrophages

Type III--immune complexes cause vasculitis

8

Describe the inheritance of duchenne muscular dystrophy (DMD); which gene is mutated?

x-linked recessive

mutation in dystrophin gene

9

6 important roles of dystrophin

myocyte protection
cell motility & division
myocyte contractility
vesicle and organelle movement
cell signaling
maintains cell junctions and shape

10

2 most used models for DMD research?

1) DMD mutant mice (don't express dystrophin)

2) golden retriever (point mutation creates a nonsense mutation)