Flashcards in Shrader & Joiner Deck (10)
Concerning myocardial necrosis:
1) why is heart muscle at greater risk
2) which spp. are more susceptible
1) bc of its continuous activity
2) herbivores are more susceptible than carnivores
What are the sequence of changes seen with myocardial necrosis
1) coagulative necrosis (12-24hrs after insult)
2) leukocytes infiltrate by days 1-3
3) by days 10-20, healing begins (fibroblasts proliferate)
4) fibrosis begins after 6-12 weeks
How does myocardial infarction differ between dogs and cats?
in dogs, there's almost always infarction of the left ventricle & other portions of the heart
in cats, infarctions are in ALL parts of the myocardium
Describe the pathogenesis of Japanese ewe
Yew spp. contain toxic alkaloids (Taxine A & B)
they inhibit Na/Ca exchange across myocytes
primary cause associated with endocarditis?
How does it differ from endocardiosis?
endocardiosis--nodules are limited to the free margins of the valves and aren't mottled-red in color
Which cat breeds are predisposed to HCM and why?
Maine coons and ragdolls
they have a mutation in myosin binding protein C
FIP replicates where and causes what type of hypersensitivity?
Type III--immune complexes cause vasculitis
Describe the inheritance of duchenne muscular dystrophy (DMD); which gene is mutated?
mutation in dystrophin gene
6 important roles of dystrophin
cell motility & division
vesicle and organelle movement
maintains cell junctions and shape