Flashcards in Shrader & Joiner Deck (10)
Loading flashcards...
1
Concerning myocardial necrosis:
1) why is heart muscle at greater risk
2) which spp. are more susceptible
1) bc of its continuous activity
2) herbivores are more susceptible than carnivores
2
What are the sequence of changes seen with myocardial necrosis
1) coagulative necrosis (12-24hrs after insult)
2) leukocytes infiltrate by days 1-3
3) by days 10-20, healing begins (fibroblasts proliferate)
4) fibrosis begins after 6-12 weeks
3
How does myocardial infarction differ between dogs and cats?
in dogs, there's almost always infarction of the left ventricle & other portions of the heart
in cats, infarctions are in ALL parts of the myocardium
4
Describe the pathogenesis of Japanese ewe
Yew spp. contain toxic alkaloids (Taxine A & B)
they inhibit Na/Ca exchange across myocytes
5
primary cause associated with endocarditis?
How does it differ from endocardiosis?
bacteria
endocardiosis--nodules are limited to the free margins of the valves and aren't mottled-red in color
6
Which cat breeds are predisposed to HCM and why?
Maine coons and ragdolls
they have a mutation in myosin binding protein C
7
FIP replicates where and causes what type of hypersensitivity?
in macrophages
Type III--immune complexes cause vasculitis
8
Describe the inheritance of duchenne muscular dystrophy (DMD); which gene is mutated?
x-linked recessive
mutation in dystrophin gene
9
6 important roles of dystrophin
myocyte protection
cell motility & division
myocyte contractility
vesicle and organelle movement
cell signaling
maintains cell junctions and shape
10
