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Principe de pharmacologie II > Signalisation I > Flashcards

Signalisation I Flashcards

(12 cards)

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1
Q

Structure RCPG (3)

A

°7 hélices transmembranaires
°3 boucles intra et 3 boucles extra
°Nterm extra et Ctrem intra

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2
Q

3 classes RCPG

A

°A: de type rhodopsine (ptit domaine nterm)
°B: de type sécrétine/glucagon (moyen domaine nterm)
°C: de type glutamate (gros domaine extra cellulaire)

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3
Q

Mécanisme prot G

A

check schéma

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4
Q

°Effecteur Gai et Gas
°Où
°Quoi
°But

A

°Adényl cyclase
°Membrane
°Enzyme
°ATP en AMPc

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5
Q

Rôle AMPc

A

Active PKA (se lie aux unités régulatrices)

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6
Q

Rôles AKAP et PDE

A

°Relocalise PKA vers ses cibles
°Dégarde AMPc

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7
Q

Suite Gas

A

1)pka phospho creb
2) phospho creb recrute CBP
3) Stimule transcription gène

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8
Q

Régulation pka (3)

A

°RGS
°Gai (inhibe adényl cyclase)
°PDE

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9
Q

Voie de Gaq (4)

A

1) Ligand active PLC
2) Grâce à PLC: PIP2 en DAG + IP3
3) IP3 active canaux calciques RE
4) Ca + DAG active PKC

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10
Q

RACK

A

Relocalise PKC vers ses cibles

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11
Q

Régulation Gaq (4)

A

° Déphosphorylation IP3
°DAG en acide urique
°Recapture Ca avec pompe ATPase
°Prot capture Ca (calmoduline)

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12
Q

Ga12/13

A

voir schéma

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Principe de pharmacologie II (7 decks)

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