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Síntesis de colesterol Flashcards

(6 cards)

1
Q

Dónde ocurre la síntesis de colesterol?

A

En el retículo endoplásmatico liso

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2
Q

Cuál es la “rate limiting step”?

A

Con la enzima HMG-CoA reductasa (desde HMG-CoA a mevalonato)

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3
Q

Cuál es el último precursor lineal?

A

Escualeno
- Ayuda a los tiburones a flotar
- Lubricante vaginal

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4
Q

Como se produce el lanoesterol?

A

Con la ciclación del escualeno

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5
Q

Funciones del colesterol

A

En los ácidos biliares para ayudar a la digestión de grasas

Fluidez de las membranas celulares (encontrados en la pared membranal, cuando hace frio alejan a los fosfolípidos y cuando hace calor los jalan)

Síntesis de hormonas esterioides (gonadales: testosterona y estrogeno)

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6
Q

Circulación enterohepática

A

Ácidos biliares salen de la vesícula biliar y viajan al intestino delgado donde se pueden desechar en heces o volver a absorberse por el torre sanguíneo (a través de lipoproteinas) y llegar al hígado

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