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Flashcards in Skin + Systemic Disease Deck (75)
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1

What is carcinoid syndrome

Facial telengiectasis
Flushing
Diarrhoea
N+V
No sweating

2

What does carcinoid syndrome indicate

GI cancer with liver mets
Bronchial
Ovarian Ca

3

What does Ectopic ACTH do

Release of melanin
Hyperpigmentation of skin, gums and greases

4

How does Paraneoplastic pemphigus present

Erosive stomatitis
Ulceration of mouth and lips
Rash

5

What is associated with it

Non-Hodgkin's
Castleman's disease

6

What is erythema Graytum Repens

Parenoplastic erythematous lesion
Look at pics
Associated with malignancy particularly lung

7

What is acquired hypertrichosis

Androgen indedendent hair growth
Acute onset of lanugo hairs at face and body

8

What causes

Colorectal cancer
Lung and breast
Drugs
Anoreixa

9

What is Bazex syndrom

Hyperkeratosis of extremeties
Can look like psoriasis so biopsy

10

What underlies Bazex syndrome

SCC
Gastric / colon / biliary adenocarcinoma

11

What is Aconthosis Nigrican's

Symmetrical brown, velvet plaques
Often neck, axilla or groin
Hyperkeratosis
Hyperpigmentation

12

What is associated with aconthosis nigrican's

Insulin resistance = benign
- Type II DM
- Obesity
- PCOS
- Acromegaly / Cushing / hypothyroid
- Prader-Willi
- OCP

Malignancy
- GI adenocarcinoma

13

What is concerning

Lip involvement
Weight loss

14

What should you look for if dermatomyositis and how

Underlying malignancy in 30%
Muscle and skin biopsy
CK
Ab - ANA / ANti-Jo1
Age / gender cancer screen and follow up 5 years
- Smear
- PSA
- Colonoscopy

15

How does it present

Inflammatory myopathy
Shawl sign - photosensitivity / violet discolouration on sun exposed area
Helitrope Rash - violet around eye
Telangiectasia
Gottron's papules on knuckles
Scalp erythema

16

What is Sweets Syndrome

Juicy nodules limited to neck and UL

17

What can cause

Post infection
Medication
Tumour

18

What is acquired ichthyosis

Dry rough skin with scaling

19

What can cause

Congenital
Lymphoproliferaive disorder
Autoimmune
Nutritional deficiency
Tumours
Medication

20

Genetic tumour syndromes

See genetics

21

What is hereditary haemorrhagic telangiectasia and what system related too

AD
GI
Telangiectasia over skin and mucous membrane

22

What is criteria

Epistaxis
Telangiectasis of lips / oral cavity / nose
Visceral lesions
FH

23

What visceral lesions

Hepatic, cerebral or spina AVN
GI telangiectasia with or without bleeding
Risk of haemorrhage

24

What is needed for Dx

2+ = possible
3+ = definite

25

What is erythema nodosum

Hypersensitivity reaction leading to inflammation of SC fat
Usually over shins
NOT bruises
Painful, blue red raised nodular lesion

26

How do you Dx and how long to resolve

6 weeks
Rest and analgesia
Steroid to reduce inflammation
Arrange follow up

Dx = clinical
Depends on cause
Biopsy
CRP and ESR
Throat swab for strep
Stool MC+S
Faecal calprotectin
CXR to exclude sarcoid / malignancy / pneumonia
Serum ACE

27

What causes

Granulomatous condition - IBD / Sarcoid / TB / fungal (macrophage around insult)
Drugs - penicillin / COCP / NSAID
Infection - strep / TB / gastroenteritis
Malignancy
Pregnancy

Pneumonic
NO - idiopathic
D - drugs - penicillin / COCP
O - OCP / pregnancy
S - sarcoid / TB
U - UC / Chron's / Bechet's
M - strep / Mycoplasma / EBV

MOST COMMON SARCOID / IBD IN EXAM

28

What causes pyoderma gangrenosum

IBD
Autoimmune hepatitis
PBC
Granulomatosis with polyangiitis
Myeloma
Myeloproliferative
RA / SLE

29

How does pyoderma gangreonsum present

Initially small red papule
Develop pustular ulcers
Tender red / blue
Overhanging necrotic edge
Purulent surface
System fever / myalgia
LL

30

How do you Rx

Oral steroid + ciclosporin = 1st line