SLE Flashcards
What is SLE
Type 3 Hypersensitivity reaction w/ autoimmune systemic inflammation
What hypersensity is SLE
Type 3
Antigen-Antibody complex deposition
What are the RF for SLE
Female
Afro caribbean
HLAB8/DR2/DR3
Drugs (Isoniazid)
What is the pathology of SLE
Impaired apoptotic debris (Self) presented to TH2
B cell activation
Antigen-antibody complex
What are the presentations of SLE
Butterfly Rash Glomerulonephritis (Lupus GN) Photosensitive Mouth Ulcers Joint pain and Raynauds Anaemia and fever
How is SLE investigated
Anaemia Raised ESR BUT NORMAL CRP Urine dip - Haematuria, proteinuria (Nephritic) Serology = ANA Ab and Anti dsDNA Low C3 and C4
What antibodies are present in SLE Serology
ANA (Sensitive)
Anti dsDNA (Specific)
Anti SMITH
How is SLE treated
Lifestyle (Avoid Sunlight)
Corticosteroids w/ Hydroxychloroquine w/ NSAID
Azathioprine if severe
What is the main aim of treating SLE
Get to a point where only Hyrdoxychloroquine needed to treat SLE
What medical managment is administered in SLE
Corticosteroid with Hydroxycholorquine with NSAIDs
What can be given in severe cases of SLE
Azithioprine
What causative drug should be stopped in patients with SLE
Isoniazid
What is the main trigger that starts the pathology of SLE
Impaired debris from apoptosis presented to Th2
What is activated at Th2 to produce antigen-antibody complexes
B cells
Why may a urine dipstick be used in SLE
Proteinuria and haematuria suggest Lupus nephritis
