Flashcards in Small Group 8 Interstitial Lung Disease Deck (10):
What is the most certain way to make a diagnosis of hypersensitivity pneumonitis?
transbronchial biopsy would show loose granulomata comprised of lymphocytes and mononuclear phagocytes and lymphocytes infiltrating the alveolar septae, this is particularly important if the T4 to T8 lymphocyte ratio is low
Serologic testing for HP gives you what information about a specific antigen.
testing for precipitating antibody tells you that the patient was sensitized to the organic antigens from the pigeons and supports the diagnosis of hypersensitivity, but is not alone diagnostic
How can you improve a patient with HP's condition?
cease exposure to causative antigenic anent
continued exposure with persistent inflammation can lead to irreversible fibrosis
brief course of corticosteriods may be beneficial for this patient with severe manifestations of the disease
Name the red rash that can accompany sarcoidosis.
erythema nodosum (not exclusive to sarcoidosis)
During sarcoidosis, what systems are not generally effected by granuloma formation?
neither kidney problems nor the nodusum lesions are caused by granuloma.
What are the associated changes on radiograph for a person suffering idiopathic pulmonary fibrosis?
sub pleural honeycombing,
small amount of ground glass
irregular and diffuse reticular lines
What patients with suspected ILD would you most likely to perform BAL and/or transbronchial biopsy in?
patients with suspected sarcodosis and hypersensitivity pneumonia
(surgical lung biopsy in selected patients when you are unable to establish a diagnosis from less invasive means)
In restrictive disease would you expect increased or decreased lung compliance?
decreased lung compliance, increased elasticity
What cells are believe to mediate the immune response in sarcoidosis?
TH1 response and the release of IL-2, IL-12, IFN-gama and TNF alpha