Substance Use Drugs

Question 1

Bupropion

Answer 1

• PO antidepressant
• Indication: short-term withdraw & maintenance
• Side Effects: dry mouth & insomnia
• Avoid along with other CNS stimulants
• Avoid in pts with hx of seizure

Question 2

Varenicline

Answer 2

• PO nicotine receptor partial agonist
• MOA: stimulates the pleasurable effects of nicotine (partially) blocking the full desired effect of nicotine
• Indication: short-term maintenance, prevents relapse (must be tapered off)
• Side Effects: HTN & hyperglycemia
• Adverse Effects: N/V, depression, suicidal ideation

Question 3

PRN Nicotine

Answer 3

• OTC replacement (gum, lozenge, patch)
• Indication: short-term withdrawn & maintenance
• Avoid nicotine while on replacement therapy
• Avoid nicotine while pregnant/breastfeeding
• Lozenges/Gum: avoid eating/drinking 15 mins before dose or during
• Avoid >20 in 24hrs
• Patch: avoid using if skin reaction, avoid concurrent use with other nicotine products

Question 4

Chlordiasepoxide

Answer 4

• For ETOH abuse

- MOA: CNS suppressant

Question 5

Disulfiram

Answer 5

• For ETOH abuse
• PO daily
• MOA: drinking alcohol = “disulfiram like reaction” = facial flushing, N/V, tachy/palpitations, hypotension, weakness, may lead to cardiorespiratory collapse, seizure & death