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Flashcards in Synaptic Communication 1 Deck (15):

Name a few benefits and Limitations of Electrical signaling in the body

Benefits: Covers long distances rapidly with minimal loss of signal Limitations: Binary, difficult to modify and Energy intensive


Define Resting membrane potential

The potential energy in the electrical gradient formed across the plasma membrane. It is the basis for neuron activity, without the membrane potential the neurotransmitters would not be sent.


Explain how a capacitor, resistor and current in a circuit can be related to the membrane potential

Resistor: Ion Channels Capacitor: Plasma membrane (between +,- charge)


What are the 4 major ion channels that maintain the membrane potential

K+ Na+ Ca2+ Cl-


What does the Nernst equation calculate?/Goldman equation?

Nernst: Equilibrium of individual ion Goldman: Equilibrium of entire plasma membrane


Name and explain the 4 types of ion channels

1. Voltage gated (changes with membrane polartization) 2. Ligand Gated Opens with ligand binds 3. Leakage 4. Physically gated


Explain Na/K ATPase pumps

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Name and label the 4 phases of the Action Potential

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1. resting phase

2. Activation phase

3. Rising phase

4. Falling phase

5. undershoot phase


In what direction does the action potential travel along the axon?

Unidirectional, Anterograde


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Draw and label action potential


What are the 2 types of Neurtransmitters and where are the released?

Small molocules (amino acids), released in presynaptic

Neuropeptides - Proteins, released pre and post synaptically


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Why are SNARE complex proteins important?

SNARE Complex proteins allow vesicle release


Name the 2 Neurotransmitter receptor types

1. Ionotropic (ligand binding)

2. Metabotropic (G - Protein, lasts longer but takes longer too)


Name the ions in the Excitatory Postsynaptic Potential and what it does?/Inhibitory

Excitatory: Na+, Ca2+ Depolarization

Inhibitory: Cl-, K- Hyperpolarization