Syphilis Flashcards
Syphilis is a sexually transmited disease caused by the bacteria______
Treponema pallidum
Syphilis can spread through direct contact from a
person with a syphillic core, or known as______.
chancre
T or F
● A pregnant woman with syphills may transmit the disease to its unborn child.
True
● Trivia: “Syphilis” is the disease brought by ________from the New world to the Old world.
the crew of Christopher Columbus
These painless chancres can occur in locations that make
them difficult to notice (e.g. the vagina or anus)
SECONDARY STAGE
EPIDEMIOLOGY
● According to the World Health Organization,______ new cases of venereal syphilis occur globally
each year.
● Globally,______ pregnant women are estimated to be infected each year; approximately one third of
these infections will result in stillbirth
11 million
1.5 million
In developing countries, transmission is largely_______, while transmission among men who have sex with men predominates in industrialized
nations.
heterosexual
caused by syphilis are a major cofactor
for bidirectional transmission of human
immunodeficiency virus (HIV).
● Genital ulcers
A single______ marks the onset of the primary stage of syphilis, but there may be multiple sores.
chancre
The chancre is usually (but not always) [3].
It appears at the location where syphilis enters the body.
firm, round, and painless
What mark the second stage of symptoms?
Skin rashes and/or mucous membrane lesions (sores in the
mouth, vagina, or anus)
This stage typically starts with the development of a rash
on one or more areas of the body
Secondary stage
In addition to rashes, signs and symptoms of secondary
syphilis may include
● fever
● swollen lymph nodes
● sore throat
● patchy hair loss
● headaches
● weight loss
● muscle aches
● fatigue
are large, raised, gray or white lesions.
They may develop in warm, moist areas like the mouth, underarm or groin region.
Condyloma lata
The ________stage of syphilis is a period when there are no visible signs or symptoms of syphilis.
latent (hidden)
● is latent syphilis where infection occurs within the past 12 months.
● is latent syphilis where infection occurs more than 12 months ago.
Early latent syphilis
Late latent syphilis
is when there is not enough evidence to confirm initial infection was within the previous 12 months.
Latent syphilis of unknown duration
Tertiary syphilis is rare and develops in a subset of untreated syphilis infections. It can appear_____ after a person gets the infection, and it can be fatal.
10-30 years
T ertiary
syphilis can affect multiple organ systems, including the:
● brain
● nerves
● eyes
● heart
● blood vessels
● liver
● bones
● joints
Occurs in around one third of untreated individuals
Tertiary syphilis
Tertiary syphilis
Has three major manifestations:
• Gummatous syphilis.
• Cardivoascular disease
• Neurosyphilis
are localized areas of granulomatous inflammation most often found on bones, skin, or subcutaneous tissues
• They contain lymphocytes, epithelioid cells, and fibroblastic cells
• They represent the host’s response to the infection
Gummas
• malaise, fever, pharyngitis
• early signs of neurologic involvement (40%): visual disturbances, hearing loss, etc.
Secondary
- painless, wart-like lesions
Condylomata lata
is the complication most often associated with the tertiary stage but can actually occur anytime after primary syphilis and con span all stages of the disease
Neurosyphilis
