T-cell lymph Flashcards Preview

Immunology > T-cell lymph > Flashcards

Flashcards in T-cell lymph Deck (15)
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1
Q

What are the most immature T-cells

A

Double negative

From bone marrow going to thymus

2
Q

What is the most mature T-cell

A

Single positive (CD4+ or CD8+)

3
Q

What is a T-cell receptor made of

A

alpha and beta chain or gamma delta chain

4
Q

What is the T-cell beta chain equal to

A

Heavy chain of B-cell

5
Q

Is there somatic hypermutation or class switching in a T-cell

A

NO

6
Q

What part of T-cell rearranges first

A

Delta

7
Q

Does rearrangement of TCR use the same enzymes as BCR

A

yes

8
Q

What happens first with expression of TCR

A

Gamma, delta, beta rearranged simultaneously

If gamma delta arrangement is unsuccessful, it becomes alpha beta

9
Q

Does TCR have allelic exlusion

A

yes, but not as tightly enforced

10
Q

Where are thymocytes educated at

A

Thymus

11
Q

What happens during T-cell positive selection

A

TCR interacts with self peptide: self MHC=survival
Changes from double positive to CD4+ or CD8+
Ensures that TCR can recognize the Ag presented by MHC

12
Q

What happens during TCR negative selection

A

TCR interacts too strongly with self=DEATH

Ensures against autoimmunity

13
Q

What happens to T-cells in second lymph tissues

A

Become Naive cells or memory cells

Long term memory formed

14
Q

(come back to finish this flashcard) Compare contrast TCR vs BCR

A

TCR Diff: Ag must be presented by MHC, positive and negative selection, never secreted

15
Q

What do negative and positive refer to with T-cell

A

CD4 and CD8