T cells Flashcards
(21 cards)
where do lymphocytes arise
in the bone marrow
where do lymphocytes fully develop
in the thymus
what can fully developed T cells recognize
MHC/peptide complexes
what do T cells express once they have fully developed in the thymus
unique T cell receptors
what are the T cell co receptors
- CD4
- CD8
what are immature T cells called
thymocytes
which part of the T cell is rearranged
the variable parts of their TCR genes in the thymus
why is the rearrangement of the TCR essentially random
this ensures that individual T cells are unique in terms of their TCR - creates diversity in the T cell repertoire
how many different antigens can the TCR recognize
only one
what are naive T cells
T cells that have not been activated by MHC/peptides
what are effector T cells
activated T cells
where does the DC stimulate the T cells using MHC/peptides
in the lymph nodes and spleen
what receptor does the CD4 T cells recognize
MHC-II/peptide
what are the jobs of the CD4 T cell
- helps activate CD8 cells - becomes cytotoxic
- helps activate B cells - to produce antibody
what receptor does the CD8 T cell recognize
MHC-I/peptide
what is the job of CD8 T cells
to develop into cytotoxic T lymphocytes (CTL)/cytotoxic T cells
what molecule assists with the docking of the TCR onto the MHC-II
CD4
what molecule assists with the docking of the TCR onto the MHC-I
CD8
what other cells are formed when effector T cells are formed
memory T cells
what are memory T cells
long-lived immune cells that “remember” past infections, allowing for a faster and stronger immune response upon re-exposure to the same antigen
