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Immunology Exam Two > T Cells > Flashcards

Flashcards in T Cells Deck (109)
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What type of T cell kills other cells but must get permission to do so by way of a cognate antigen?

Killer T cells

1

What type of T cell helps other cells but must get permission to do so?

Helper T cells

2

Where do T cells mature?

Thymus (T for thymus)

3

From where are white blood cells made?

Bone marrow

4

Where do T cells circulate?

Blood and lymph

5

What is the function of T cell receptors located on the surface of T cells that are "antibody like receptors"?

Specialize in recognizing protein antigens presented by MHCs (antigen = peptide)

6

How many T cells are in the body?

About 300 billion

7

What is another name for killer T cells?

Cytotoxic T cells (CTLs)

8

What activates killer T cells?

MHC I

9

How do killer T cells kill other cells?

Trigger them to commit suicide (therefore killing the virus inside, as well)

10

What activates helper T cells?

MHC II on APCs

11

What type of T cell can secrete cytokines?

Helper T cells

12

What cells keep the immune system from overreacting?

Regulatory T cells

13

What cytokines can be released from helper T cells?


Interleukin 2 (IL-2), TNF, and interferon gamma (IFN-gamma)


14

What type of T cell is activated by MHC I being presented on cell surfaces?

Killer T cell (CTLs)

15

What type of T cell is activated by MHC II being presented on APCs?

Helper T cells

16

What is required in order for helper and killer T cells to function?

Activation

17

What is the function of the T cell receptor?

Recognizing the cognate antigen

18

What is the function of the co-receptor?

Recognizing the MHC (I or II)

19

What is the purpose of co-stimulation?

Recognition of other molecules

20

More is known about activation of which T cell, overall?

Helper T cell

21

What happens to a T cell when it sees "self" being presented by other cells?

It dies (deemed unnecessary)

22

What happens to a T cell if it recognizes self antigen but doesn't get co-stimulated?

It will be rendered inactive (anergized) and will eventually die

23

What happens to a T cell if it sees "nonself" and gets co-stimulated?

It therefore becomes activated

24

When the usual process of a T cell dying when recognizing "self" does not occur and the T cells remain, what issue can result?

Autoimmune disease

25

Is a T cell receptor the same as an antibody?

No; they are antibody-like

26

Which is more diverse: T cell or B cell receptors?

B cell receptors

27

What type makes up the majority of T cell receptors (95%)?

Alpha-beta (traditional)

28

Are all T cell receptors on mature T cells identical?

Yes, for the most part (but may be some exceptions)

29

What is the name given to the group of signaling proteins?

CD3