T3 L8: Blood science results Flashcards

1
Q

What % of clinical decisions are based on data from a lab in the UK?

A

70%

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2
Q

What does the Histology and Cytology division of pathology test for?

A

Tissue. Tests for malignancy, infections, auto-immune

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3
Q

What does the Bacteriology and Virology division of pathology test for?

A

Causes of infection. Tests cultures, antigen and antibody testing and PCR. Responsible for antibiotic use

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4
Q

What does the Haematology division of pathology division test for?

A

Diseases of the blood, transfusion and coagulation

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5
Q

What does the Biochemistry and Immunology division of pathology test for?

A

Measurement of analytes in blood, urine, CSF…

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6
Q

Why are some steroid hormones so similar in structure?

A

Because they are all derived from the same molecule. Eg. Cholesterol

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7
Q

What is the most abundant ion in the blood?

A

Sodium

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8
Q

Order these from most abundant to least abundant in the blood: Creatinine, cortisol, sodium and free thyroxine (T4)

A
  1. sodium
  2. creatinine
  3. cortisol
  4. free thyroxine (T4)
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9
Q

What are sodium, potassium, urea, and creatinine results used to determine?

A

Renal function

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10
Q

What are total protein, albumin, bilirubin, alkaline phosphatase, and alanine transaminase results used to determine?

A

Liver function

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11
Q

What are total protein, albumin, calcium, phosphate, and alkaline phosphatase results used to determine?

A

The bone profile

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12
Q

What are TSH (free T4 and T3) results used to determine?

A

Thyroid function

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13
Q

What are total cholesterol, HDL-cholesterol, non-HDL cholesterol, and triglyceride results used to determine?

A

The lipid profile

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14
Q

Why are creatinine levels higher in men?

A

Men have a higher muscle mass than woman generally and creatinine is produced by muscles. Muscle mass is also dependent on age and therefore so is creatinine

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15
Q

What are the 5 sources of alkaline phosphatase (ALP)?

A

Liver, bone, intestine, kidney, and placenta

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16
Q

What does bone alkaline phosphatase (ALP) show?

A

The rate of bone growth. Will be a lot higher in children compared to adults

17
Q

Give an example of a hormone that changes during each trimester of pregnancy

A

Thyroid stimulating hormone - TSH (free T4 and T3)

18
Q

Where is Thyroid stimulating hormone (TSH) produced?

A

Pituitary gland

19
Q

What is Thyrotrophin releasing hormone (TRH)?

A

Involved in thyroid gland regulation and function

20
Q

What hormone moves in the opposite direction to TSH?

A

Thyroxine (T4). So when TSH is low, T4 should be really high

21
Q

Why are cortisol level highest in the morning?

A

Because cortisol follow a circadian rhythm

22
Q

With what 2 types of disease would alkaline phosphatase be elevated?

A

Liver and bone disease

23
Q

What do elevated troponin levels indicate?

A

Heart disease (MI)