Tamoxifen Flashcards
(6 cards)
1
Q
how does tamoxifen work
A
an anti-oestrogen which induces gonadotrophin release by occupying receptors in the hypothalamus
2
Q
give some indications for tamoxifen use
A
- pre and peri-menopausal women with oestrogen receptor positive breast cancer
(prevention of gynaecomastia in men, chemoprevention of breast cancer)
3
Q
what are the side effects of tamoxifen
A
hot flushes and sweats
vaginal effects - discharge/itch/dryness
change in periods
nausea/indigestion
eye problems
headache
loss of sex drive
hair thinning
skin rash
weight gain
tiredness
4
Q
what is a major drug which interacts with tamoxifen
A
rifampicin
5
Q
what is the major contraindication to tamoxifen use
A
pregnancy
6
Q
how long should you use contraception for after stopping tamoxifen
A
2 months
