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Flashcards in Test 1 Deck (88)
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1

list some of the innate immunity

Skin
tears
sweat
saliva
normal flora
phagocytic cells
Natural Killer cells
inflammation

2

what is a CD4 cell

its a T helper cell

3

what is a CD8 cell

cytotoxic T cells

4

What marker/receptors do B cells have on them

CD19

5

what are the byproducts of complement proteins being split?

anaphylatoxins
chemotaxins
opsonins

6

What are the "acquired" process?

-Macrophage engulfs foreign material
- Macrophage selects and processes an antigen
-Macrophage presents antigen wrapped in MHC-2 proteins to CD4 lymphocyte
-CD4 lymphocyte presents antigen to B cell and CD8 T-cell
-Antigen must be wrapped in MHC-1 proteins for CD8 cell to accept it
-B-cell converts to plasma cell and produces antibodies
-CD8 cell produces cytokines

7

what does CD stand for?

cluster of differentiation

8

What are CD numbers for?

they are assigned to lymphocytes to distinguish them

9

what marker do B cells have?

CD19

10

what markers do cytotoxic T cells have

CD8

11

what markers do helper T cells have

CD4

12

what markers natural killer cells have

none

13

What do CD4 cells do

help B-cells and CD8 cells by presenting antigen
Induces clonal expansion by releasing cytokines

14

Where is complement involved

in both innate and acquired immunity

15

How can Properdin and MBL pathways activated

directly by bacteria, viruses, yeasts, etc.

16

What does complement activation result in

a hole in the cell membrane

17

What is the classical pathway activated by

antibody to antigen

18

Which antibody always activates complement

IgM

19

Why does IgG not always activate complement

they have to bind close together on cell membrane

20

what does anaphylatoxin promote

inflammation by causing mast cells to release granular contents (histamine)
1) INCREASED VASCULAR PERMEABILITY
2) SMOOTH MUSCLE CONTRACTION

21

what does chemotaxin cause

PHAGOCYTIC CELLS TO BE RECRUITED TO THE AREA OF ANTIBODY/ANTIGEN REACTION – SEGMENTED NEUTROPHILS
– MACROPHAGES

22

what does opsonin do

ALERT
binds to cell wall and allows macrophage to recognize the abnormal cell more easily
-antibody
-complement fragements (C3b)
macrophage phagocytosis the cell presents to a CD4
CD4 presents to B cell
B cell changes to plasma cell to produce antibody

23

what are antigens

CHEMICAL CONSTITUENTS ON CELL MEMBRANE
PROTEINS, POLYSACCHARIDES

24

what do antigens do?

stimulate an antibody or cytotoxic response

25

what is the meaning of antigen dosage

amount of antigen introduced

26

what is the antigen route

IV is more antigenic than oral administration

27

what is the size of an antigen

10,000 daltons

28

what is an epitope

SMALL PORTION OF THE MOLECULE THAT ELICITS A SPECIFIC RESPONSE

29

what is an antigenic determinant

ANTIBODY PRODUCED THAT IS SPECIFIC FOR THE EPITOPE
MOLECULE MAY HAVE MORE THAN ONE EPITOPE

30

what are the RBC antigens

glycoproteins or glycolipids