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Flashcards in Test 4 Deck (104)
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0

List five antibodies that are IgG antibodies.

Anti-K, Anti- Fya, Anti-Fyb, Anti- Jka, Anti-Jkb, anti-S
(Anti-kell, anti- Duffy, anti-Kidd)

1

List five antibodies that are IgM antibodies.

Anti- Lea, anti-Leb, anti-I, anti-P1, anti-M, anti-N, anti-Lua
Anti-Lewis

2

Which class of antibody reacts at room temperature but not at 37 degrees Celsius?

IgM

3

List four antibodies whose reactivity would show increased agglutination if the screening cells were pre-treated with enzymes (do not include Rh system antibodies).

Kell, Kidd
Anti-Jka, anti-Jkb, anti-C, anti-K

4

List four antigens that are removed from the red blood cell membrane by enzyme treatment.

M, N, Fya, Fyb

5

List three antigens that are not expressed on cord blood cells.

Lea, Leb, I

6

Which antigen is most immunogenic next to the D antigen?

K

7

What is another name for the anti-PP1Pk antibody produced by people with the p genotype?

Anti-Tja

8

Which of these antibodies might be present in a patient who has never been transfused nor pregnant?
a. Anti-Lea
b. Anti-Fya
c. Anti-Jka
d. Anti-N
e. Anti-P1
f. Anti-K
g. Anti-Jsa
h. Anti-S

a. Anti-Lea
d. Anti-N
e. Anti-P1

9

List two antigens that are made from another antigen.

I, Leb

10

Which antibodies are very dangerous because their titers fall rapidly to undetectable levels?

Kidd antibodies

11

Which antibody causes paroxysmal cold hemoglobinuria? Is it IgM or IgG?

Auto anti-P, IgG

12

If a patient builds an anti-U antibody, which three antigens are not present on their red blood cells?

U, S, s

13

Which antigen is associated with Chronic Granulomatous Disease?

Kx

14

State whether finding compatible blood with the following antibodies would be “easy” or “difficult”
a. Anti-Jsa b. Anti-Kpb c. Anti-K d. Anti-k e. Anti-Fya f. Anti-S g. Anti-s

a. Anti-Jsa easy- antigen low incidence
b. Anti-Kpb difficult- antigen high incidence
c. Anti-K easy- antigen low incidence
d. Anti-k difficult- antigen high incidence
e. Anti-Fya easy- antigen low incidence
f. Anti-S easy- antigen low incidence
g. Anti-s easy 10%- antigen low incidence 10%

15

Describe “dosage” effect.

Reaction is going to be stronger with homozygous than heterozygous

16

Which group of antibodies typically give a “mixed field” agglutination pattern in serological testing?

Lua and Lub

17

What procedure would help distinguish an anti-K and anti-Fya antibody on an Identification Cell Panel?

Addition of enzymes

18

Which antibody agglutinates all adult red blood cells but will not agglutinate Group O cord blood cells?

Anti-I

19

If a patient has the genotype M+N+S-s-, what other antigen is also missing?

U antigen

20

Which of the following antigens is a low incidence antigen?
a. k (cellano)
b. Kpa (Penny)
c. Kpb (Rautenberg)
d. Jsb (Matthews)

B. Kpa (Penny)

21

List three common characteristics of IgG blood group antibodies.

React at 37 degrees Celsius
Don't usually activate complement
Cause HDN

22

Which antigen is missing from the patient’s red blood cells if they have McLeod syndrome?

Kx

23

Which of the following antibodies might cause Hemolytic Disease of the Fetus and Newborn?
a. Anti-Lea
b. Anti-K
c. Anti-N
d. Anti-Fya
e. Anti-P1
f. Anti-s

b. Anti-K
d. Anti-Fya
f. Anti-s

24

What procedure could you use to identify an anti-I antibody?

Group O cord blood cells

25

Which antibody causes Cold Agglutinin Disease?

I

26

Which antibody is sometimes formed after infection with Mycoplasma pneumoniae?

Anti-I

27

Which antibody is called a “biphasic” antibody? What is another name for this antibody?

Auto anti-P
Donath-Landsteiner

28

Why do we “grade” agglutination reactions?

May show there is two antibodies other 1

29

What procedure can we perform to eliminate interference in the antibody screen or identification panel caused by a cold reacting autoantibody?

Pre-warming