Flashcards in Test 1 Deck (21):
Who sequenced the HGP?
The government and a private corporation together. (The NIH and the Celera Corp)
How much did the HGP cost?
3 billion dollars and said to have an economic impact of $796 million. THIS WAS SUPER CHEAP
When was the HGP completed?
Completed in 2003
Who owns the HGP?
The people! Payed for by our taxes.
What were the goals of the HGP? (7)
1. Sequence of >95% of the nucleotides 2. Identify all the genes 3. Produce a physical and linkage map 4. Reduce cost of DNA sequencing
5. Develop genome-scale functional
analyses (e.g. microarrays)
6. Describe genetic variation among
7. Set up Ethical, Legal and Social
Why did we even do the HGP?
To help medicine, comparative genomics, population genetics
What did the HGP actually tell us?
–1.5% of genome encodes proteins
–96% similarity with chimpanzee genome *
–0.17% of the human genome varies between individuals
-More than 3000 genes linked to disease
look at def on ppt example
What are three examples of discrete traits?
Eye color, tongue curling, earlobe attachment
What are three examples of continuous traits?
Obesity, diabetes, vision *Most traits continuous
What is a polygenic trait?
Trait influenced by many genes
What is continuous variation a result of? Environment or genes?
A combination of both
Total PHENOTYPIC variance
Varianve due to genetic factors
Variance due to difference in enviromental influence
Variance due to difference btw. genes and environment
What is ANOVA
An analysis method which in which environment and relateness are manipulated, plot the relatives against eachother and document slope (gives heritabilit)
Vg+Ves/Vt *Ves is negligible