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Flashcards in Test 1 Deck (21):
1

Who sequenced the HGP?

The government and a private corporation together. (The NIH and the Celera Corp)

2

How much did the HGP cost?

3 billion dollars and said to have an economic impact of $796 million. THIS WAS SUPER CHEAP

3

When was the HGP completed?

Completed in 2003

4

Who owns the HGP?

The people! Payed for by our taxes.

5

What were the goals of the HGP? (7)

1. Sequence of >95% of the nucleotides 2. Identify all the genes 3. Produce a physical and linkage map 4. Reduce cost of DNA sequencing
technology
5. Develop genome-scale functional
analyses (e.g. microarrays)
6. Describe genetic variation among
human populations
7. Set up Ethical, Legal and Social
Implications program

6

Why did we even do the HGP?

To help medicine, comparative genomics, population genetics

7

What did the HGP actually tell us?

–25k genes
–1.5% of genome encodes proteins
–96% similarity with chimpanzee genome *
–0.17% of the human genome varies between individuals
-More than 3000 genes linked to disease

8

Heritability

look at def on ppt example

9

What are three examples of discrete traits?

Eye color, tongue curling, earlobe attachment

10

What are three examples of continuous traits?

Obesity, diabetes, vision *Most traits continuous

11

What is a polygenic trait?

Trait influenced by many genes

12

What is continuous variation a result of? Environment or genes?

A combination of both

13

Vp=

Total PHENOTYPIC variance

14

Vg=

Varianve due to genetic factors

15

Ve=

Variance due to difference in enviromental influence

16

Vgxe=

Variance due to difference btw. genes and environment

17

Vp Equation:

Vp=Vg+Ve+Vgxe

18

Heritability h2=

Vg/Vp

19

What is ANOVA

An analysis method which in which environment and relateness are manipulated, plot the relatives against eachother and document slope (gives heritabilit)

20

Rmza=

Vg+Ves/Vt *Ves is negligible

21

why would you get overestimate of heritability?

Because Ves is actually not negligible sometimes