Test 1 Immunoglobulins Flashcards Preview

Blood Bank Test 1 > Test 1 Immunoglobulins > Flashcards

Flashcards in Test 1 Immunoglobulins Deck (41)
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1

Gamma heavy chain

IgG

2

Mu heavy chain

IgM

3

Alpha heavy chain

IgA

4

Epsilon heavy chain

IgE

5

Delta heavy chain

IgD

6

180,000 D molecular weight

IgG

7

900 kD molecular weight

IgM

8

400 kD molecular weight

IgA

9

180 molecular weight

IgE and IgD

10

IgG shape

monomer

11

IgM shape

pentamer

12

IgA shape

dimeric; monomer/polymer (2IgA molecules joined by J chain)

13

IgE shape

monomer (in serum)

14

IgD shape

monomer

15

Most clinically significant

IgG

16

Destroys antigen coated transfused red cells

IgG

17

Macrophage Fc receptors

IgG

18

Reaction temp at 37 degrees

IgG

19

Activates complement

IgG and IgM

20

Crosses the placenta

IgG

21

Hemlytic disease of the newborn

IgG

22

Naturally occuring

IgM

23

Interfers with detection of IgG anitbodies

IgM

24

Primary immune response

IgM

25

Subclasses IgM1, IgM2

IgM

26

First immunoglobulin produced in fetus

IgM

27

Antibodies in ABO blood system

IgM

28

Confined to blood stream

IgM

29

Antibody-antigen agglutination

IgM

30

May enhance autoimmune RBC hemolysis

IgA

31

Sound in secretions

IgA

32

No bacteriocidal effects

IgA

33

Localizes infectious agents

IgA

34

Subclasses IgA1, IgA2

IgA

35

Triggers cellular release of histamine

IgE

36

Use antihistamines during transfusion to prevent allergic react/ anaphylaxis

IgE

37

Shortests half life, highest catabolic rate, lowest synthesis rate

IgE

38

Bound by Fc portion to basophils and mast cells

IgE

39

Increased vascular permeability

IgE

40

May relate to maturation/ differentiation of B cells

IgD

41

No blood group antibodies

IgD