Test 2 Feddock Flashcards Preview

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Flashcards in Test 2 Feddock Deck (12):
1

Risk of bias

Similar prognosis

Accurate measurements of exposures/outcomes

Complete and adequate follow up

2

SImilar prognosis

Accureate measurements of exposrues and outcomes

Complete and adequate follow up

Random and allocaiton concealment

Defined objective outcomes and appropritate blinding

Loss to follow up and intention to tx

3

Directness

Diff between pop of interest and study participants

Diff in tx between pop of interest and study part

Use of surrgoate outcome instead of outcome of interest

Indirect comparison betwen presence/absence of an exposure or risk factor

4

Cosistency

Effect estimates consistent across subgroups

Effect estimates consistent across outcome measurements

Heterogeneity is minla

5

Precision

Use CI

6

Publication bias

Look at the funnel plot

7

Alpha versus Beta
Power vs. confience

Alpha - prob of finding diff when NOT one
Confidence

Beta- false negative
Power - % that you find a true difference when there is one

8

What effects heterogeneity

Different populations, different doses/administration

9

Cointervention vs. surveillance bias

Cointervention - failure of blinding the physicians

Surveillance - think COHORT study

10

External validity effects

Must look at the population of the patients in the study

11

Question to ask about negative study

Was power high enoug h

12

Meta advantages

Generalizability, power, allows for comparison